Rv3582c - 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase ispD

Expression: Most Significant Conditions for Rv3582c

Protein Domains

Gene Information
Locus	Rv3582c
Symbol	ispD
Gene Name	4-diphosphocytidyl-2-C-methyl-D-erythritol synthase ispD
Location	4024344 - 4025039 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:696 bp Protein:232 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32720
Related Genes	Acel_0080 BL0324 CE2521 cg2945 DIP1973 jk0308 MAP0476 MAV_0571 Mkms_4825 ML0321 Mmcs_4739 MSMEG_6076 MT3688 MUL_4158 Mvan_4129 Mvan_4130 nfa4360 PPA0353 SAV3969
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3582c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3582c Transcript 1
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPA
DRTDEARQILGHRAMIVAGGSNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVAR
VVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQR
GSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG*

Genomic Sequence

>Rv3582c
GTGGTCAGGGAAGCGGGCGAAGTAGTTGCGATCGTCCCGGCTGCGGGGTCGGGGGAGCGG
TTGGCCGTCGGTGTGCCCAAGGCGTTTTACCAGCTCGACGGGCAGACTCTCATTGAGCGG
GCCGTCGATGGCCTGCTGGATTCGGGGGTAGTTGACACCGTTGTTGTGGCCGTGCCCGCC
GACCGTACGGACGAGGCGAGGCAGATCCTCGGCCACAGGGCGATGATTGTGGCGGGTGGG
TCGAATCGCACTGACACCGTGAACCTGGCGCTGACAGTGCTGTCCGGGACCGCGGAGCCG
GAGTTTGTGCTTGTGCATGATGCCGCGCGGGCACTGACACCACCGGCCCTGGTCGCCCGG
GTGGTCGAGGCGTTGCGGGACGGTTATGCCGCCGTCGTTCCCGTACTGCCGCTTTCTGAC
ACCATCAAGGCCGTGGATGCCAACGGGGTGGTCCTGGGCACGCCGGAACGAGCCGGGCTG
CGGGCCGTGCAGACCCCACAAGGGTTCACTACCGACCTGCTGCTGCGGTCATATCAGCGC
GGCTCCCTAGACCTTCCAGCCGCCGAGTACACCGATGACGCGTCGCTGGTCGAGCATATC
GGCGGCCAGGTGCAGGTGGTCGACGGCGATCCGCTGGCGTTCAAGATCACCACCAAACTG
GATCTGTTGCTGGCCCAAGCTATAGTGCGCGGGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:MEPCT 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - IPI	active	njamshidi	2012-10-05
	PMID: 16321944 RK. Dhiman, ML. Schaeffer et al. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. J. Bacteriol. 2005
Term	TBRXN:MEPCT 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - ISS	active	njamshidi	2012-10-05
	PMID: 16321944 RK. Dhiman, ML. Schaeffer et al. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. J. Bacteriol. 2005
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Name	4-diphosphocytidyl-2-C-methyl-D-erythritol synthase	active	mjackson	2012-10-05
	Non-mevalonate isopentenyl diphosphate synthesis