Rv3818 - hypothetical protein

Expression: Most Significant Conditions for Rv3818

Protein Domains

Gene Information
Locus	Rv3818
Symbol
Gene Name	hypothetical protein
Location	4282449 - 4283999 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1551 bp Protein:517 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	3459
Related Genes	MAP0204c MAV_0200 Mkms_5114 Mmcs_5026 MSMEG_6410 MT3926 MUL_5001 Mvan_5657 nfa1470
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3818
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3818 Transcript 1
MQVTSVGHAGFLIQTQAGSILCDPWVNPAYFASWFPFPDNSGLDWGALGECDYLYVSHLH
KDHFDAENLRAHVNKDAVVLLPDFPVPDLRNELQKLGFHRFFETTDSVKHRLRGPNGDLD
VMIIALRAPADGPIGDSALVVADGETTAFNMNDARPVDLDVLASEFGHIDVHMLQYSGAI
WYPMVYDMPARAKDAFGAQKRQRQMDRARQYIAQVGATWVVPSAGPPCFLAPELRHLNDD
GSDPANIFPDQMVFLDQMRAHGQDGGLLMIPGSTADFTGTTLNSLRHPLPAEQVEAIFTT
DKAAYIADYADRMAPVLAAQKAGWAAAAGEPLLQPLRTLFEPIMLQSNEICDGIGYPVEL
AIGPETIVLDFPKRAVREPIPDERFRYGFAIAPELVRTVLRDNEPDWVNTIFLSTRFRAW
RVGGYNEYLYTFFKCLTDERIAYADGWFAEAHDDSSSITLNGWEIQRRCPHLKADLSKFG
VVEGNTLTCNLHGWQWRLDDGRCLTARGHQLRSSRP*

Genomic Sequence

>Rv3818
GTGCAGGTCACAAGCGTTGGTCACGCCGGCTTTCTGATCCAGACCCAGGCCGGCAGCATC
CTGTGCGACCCTTGGGTCAATCCGGCCTACTTTGCGTCTTGGTTTCCGTTCCCCGACAAC
AGCGGGCTGGACTGGGGCGCTTTGGGTGAGTGCGATTATCTGTATGTCTCGCACCTACAT
AAGGACCACTTCGACGCGGAAAATCTACGAGCGCACGTCAACAAGGACGCCGTCGTGCTG
CTGCCCGACTTTCCGGTACCCGACCTGCGAAATGAGTTGCAGAAGTTAGGATTTCATCGG
TTCTTCGAAACCACCGACTCGGTCAAACACCGCCTGAGGGGACCCAACGGCGATCTCGAC
GTGATGATCATCGCACTGCGGGCCCCCGCCGACGGTCCGATCGGCGACTCGGCGCTAGTC
GTTGCCGACGGCGAAACAACGGCTTTCAACATGAACGACGCCCGCCCGGTCGATTTGGAC
GTGCTGGCATCGGAGTTCGGTCACATCGACGTGCATATGCTGCAGTACTCGGGCGCGATC
TGGTACCCGATGGTCTACGACATGCCGGCGCGCGCGAAGGATGCGTTCGGCGCCCAAAAG
CGGCAACGGCAGATGGACCGTGCTCGCCAGTACATCGCGCAGGTGGGAGCGACGTGGGTG
GTGCCGTCGGCGGGGCCGCCATGCTTTTTAGCCCCCGAGCTGCGCCACCTCAACGACGAC
GGTAGCGATCCGGCCAATATCTTCCCCGACCAGATGGTGTTCCTGGATCAGATGCGGGCG
CACGGCCAGGACGGCGGGCTGCTGATGATCCCCGGCTCGACTGCGGATTTCACTGGTACA
ACCCTGAATTCATTGCGCCATCCACTGCCCGCCGAACAGGTCGAGGCCATCTTTACCACC
GACAAAGCCGCATACATCGCTGACTATGCCGACCGGATGGCGCCGGTGCTCGCCGCGCAA
AAGGCTGGCTGGGCCGCCGCCGCCGGCGAGCCACTGCTGCAGCCGCTGCGCACCCTGTTC
GAGCCGATCATGCTGCAAAGCAACGAGATCTGCGACGGCATCGGATACCCGGTCGAGCTC
GCCATCGGTCCCGAAACCATTGTTTTGGACTTTCCGAAAAGAGCTGTACGAGAACCGATT
CCCGACGAGAGGTTCCGCTACGGGTTCGCGATCGCGCCGGAGCTGGTGCGCACGGTGCTG
CGCGACAACGAACCCGACTGGGTCAACACCATCTTCTTATCCACCCGATTTCGGGCATGG
CGGGTTGGTGGCTACAACGAATACCTTTACACGTTCTTCAAGTGTCTGACCGACGAACGC
ATCGCCTACGCCGACGGCTGGTTCGCCGAGGCCCACGATGACTCCTCATCGATCACCCTG
AACGGTTGGGAGATCCAGCGCCGCTGCCCCCATCTCAAAGCCGACCTATCGAAATTCGGT
GTGGTGGAAGGCAACACGCTCACTTGTAACCTGCACGGCTGGCAGTGGCGTCTGGACGAC
GGTCGCTGCCTCACCGCCCGGGGCCATCAACTACGCAGTTCACGGCCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:UAMRH UDP-MurNAc Hydroxylase - IPI	active	njamshidi	2012-10-05
	See PMID: 15522883, 15805521. N glycolyation of N acetyl moiety. Bioechemically demonstrated in M smegmatis, must occur in some way in TB, BLAST search identified most likely candidate to be RV3818 authors,S. Mahapatra,T. Yagi,JT. Belisle,BJ. Espinosa,PJ. Hill,MR. McNeil,PJ. Brennan,DC. Crick Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate. J. Bacteriol. 2005
Term	TBRXN:UAMRH UDP-MurNAc Hydroxylase - IPI	active	njamshidi	2012-10-05
	See PMID: 15522883, 15805521. N glycolyation of N acetyl moiety. Bioechemically demonstrated in M smegmatis, must occur in some way in TB, BLAST search identified most likely candidate to be RV3818 authors,JB. Raymond,S. Mahapatra,DC. Crick,MS. Pavelka Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J. Biol. Chem. 2005
Term	TBRXN:UAMRH UDP-MurNAc Hydroxylase - ISS	active	njamshidi	2012-10-05
	See PMID: 15522883, 15805521. N glycolyation of N acetyl moiety. Bioechemically demonstrated in M smegmatis, must occur in some way in TB, BLAST search identified most likely candidate to be RV3818 authors,S. Mahapatra,T. Yagi,JT. Belisle,BJ. Espinosa,PJ. Hill,MR. McNeil,PJ. Brennan,DC. Crick Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate. J. Bacteriol. 2005
Term	TBRXN:UAMRH UDP-MurNAc Hydroxylase - ISS	active	njamshidi	2012-10-05
	See PMID: 15522883, 15805521. N glycolyation of N acetyl moiety. Bioechemically demonstrated in M smegmatis, must occur in some way in TB, BLAST search identified most likely candidate to be RV3818 authors,JB. Raymond,S. Mahapatra,DC. Crick,MS. Pavelka Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J. Biol. Chem. 2005
Name	N-acetylmuramic acid hydroxylase	active	mjackson	2012-10-05
	Peptidoglycan precursor synthesis
Symbol	namH	active	mjackson	2012-10-05
	Peptidoglycan precursor synthesis
Symbol	Symbol: namH	active	jgalag	2012-03-16
Term	EC:1.7.1.4 Nitrite reductase (NAD(P)H). - NR	active	extern:JZUCKER	2012-03-06
	Inferred from direct assay authors,JB. Raymond,S. Mahapatra,DC. Crick,MS. Pavelka Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J. Biol. Chem. 2005
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,JB. Raymond,S. Mahapatra,DC. Crick,MS. Pavelka Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J. Biol. Chem. 2005