Rv3823c - membrane transport protein mmpL8
Protein Domains

Gene Information
LocusRv3823c
SymbolmmpL8
Gene Namemembrane transport protein mmpL8
Location4288260 - 4291529 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:3270 bp
Protein:1090 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number22155
Related GenesMAP3080 MAV_3895 Mkms_0531 Mmcs_0519 MSMEG_0763 MT3931 MUL_1909 Mvan_0683
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionTranscription Rv0757activesourish102012-10-05
Co-expression (Functional linkage)
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
NameRND superfamily inner membrane transporter thought to be involved in the translocation of a diacylated precursor of sulfolipid I across the plasma membraneactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
OtherTBPWY:Polymethyl-branched acyltrehalosesactivemjackson2012-03-05
RND superfamily inner membrane transporter thought to be involved in the translocation of a diacylated precursor of sulfolipid I across the plasma membrane (phenotypic [mycobacterial recombinant strains])
SE. Converse, JD. Mougous et al. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc. Natl. Acad. Sci. U.S.A. 2003
OtherTBPWY:Polymethyl-branched acyltrehalosesactivemjackson2012-03-05
RND superfamily inner membrane transporter thought to be involved in the translocation of a diacylated precursor of sulfolipid I across the plasma membrane (phenotypic [mycobacterial recombinant strains])
P. Domenech, MB. Reed et al. The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J. Biol. Chem. 2004
OtherEC:activejjmcfadden2012-03-05
Inferred from direct assay
SE. Converse, JD. Mougous et al. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc. Natl. Acad. Sci. U.S.A. 2003