Rv3826 - fatty-acid-CoA ligase fadD23

Expression: Most Significant Conditions for Rv3826

Protein Domains

Gene Information
Locus	Rv3826
Symbol	fadD23
Gene Name	fatty-acid-CoA ligase fadD23
Location	4299812 - 4301566 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1755 bp Protein:585 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	26689
Related Genes	MAP3752 MT3934 MUL_1432
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3826
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3826 Transcript 1
MVSLSIPSMLRQCVNLHPDGTAFTYIDYERDSEGISESLTWSQVYRRTLNVAAEVRRHAA
IGDRAVILAPQGLDYIVAFLGALQAGLIAVPLSAPLGGASDERVDAVVRDAKPNVVLTTS
AIMGDVVPRVTPPPGIASPPTVAVDQLDLDSPIRSNIVDDSLQTTAYLQYTSGSTRTPAG
VMITYKNILANFQQMISAYFADTGAVPPLDLFIMSWLPFYHDMGLVLGVCAPIIVGCGAV
LTSPVAFLQRPARWLQLMAREGQAFSAAPNFAFELTAAKAIDDDLAGLDLGRIKTILCGS
ERVHPATLKRFVDRFSRFNLREFAIRPAYGLAEATVYVATSQAGQPPEIRYFEPHELSAG
QAKPCATGAGTALVSYPLPQSPIVRIVDPNTNTECPPGTIGEIWVHGDNVAGGYWEKPDE
TERTFGGALVAPSAGTPVGPWLRTGDSGFVSEDKFFIIGRIKDLLIVYGRNHSPDDIEAT
IQEITRGRCAAIAVPSNGVEKLVAIVELNNRGNLDTERLSFVTREVTSAISTSHGLSVSD
LVLVAPGSIPITTSGKVRRAECVKLYRHNEFTRLDAKPLQASDL*

Genomic Sequence

>Rv3826
ATGGTTTCGCTTTCCATCCCCTCGATGTTGCGCCAGTGCGTCAACCTGCACCCGGACGGC
ACGGCATTCACTTACATCGATTACGAACGGGATTCGGAGGGCATAAGTGAAAGCCTGACG
TGGTCGCAGGTGTATCGGCGAACCCTAAACGTTGCAGCAGAAGTCCGCCGCCATGCCGCA
ATTGGTGACCGTGCAGTGATATTGGCCCCACAAGGACTCGATTATATTGTTGCTTTTCTG
GGCGCTTTACAGGCCGGTCTTATTGCGGTTCCACTTTCGGCTCCGCTCGGCGGCGCCAGC
GATGAACGTGTTGACGCGGTAGTGCGTGACGCGAAACCCAATGTCGTTCTGACAACATCC
GCGATAATGGGCGATGTCGTCCCGCGCGTTACGCCACCGCCCGGTATTGCCAGCCCGCCA
ACGGTTGCGGTCGATCAACTAGATCTGGACTCGCCGATACGATCTAATATTGTGGACGAT
TCTCTCCAAACAACCGCATATTTGCAGTATACGTCGGGATCGACCCGCACACCTGCCGGT
GTAATGATTACCTACAAGAATATATTGGCAAATTTCCAGCAGATGATTTCCGCCTATTTC
GCCGACACCGGAGCCGTACCGCCATTGGACCTTTTCATTATGTCGTGGCTACCGTTCTAT
CATGACATGGGTTTGGTTCTGGGAGTTTGTGCGCCGATTATCGTAGGATGCGGCGCTGTG
CTCACAAGCCCGGTGGCGTTTCTGCAGCGACCAGCCCGGTGGCTGCAATTGATGGCACGC
GAGGGCCAGGCGTTTTCGGCGGCACCGAACTTCGCCTTCGAACTGACGGCAGCAAAAGCA
ATAGATGACGACTTGGCCGGGCTCGACCTTGGACGGATCAAAACCATCCTCTGCGGCAGT
GAAAGGGTGCATCCGGCGACCCTCAAGCGCTTTGTCGACCGGTTTAGCCGTTTCAATCTT
CGAGAATTCGCAATTCGGCCCGCGTACGGACTCGCGGAAGCCACGGTGTATGTGGCGACC
AGCCAAGCCGGCCAACCCCCAGAAATCCGTTACTTCGAACCCCACGAACTTTCCGCTGGG
CAGGCCAAGCCGTGCGCAACCGGGGCGGGCACAGCTCTGGTCAGTTACCCGCTGCCGCAA
TCACCCATTGTTCGGATCGTCGATCCCAACACCAATACCGAGTGCCCACCCGGAACAATC
GGTGAGATCTGGGTACACGGCGACAATGTCGCCGGCGGCTATTGGGAAAAGCCTGACGAG
ACTGAACGCACCTTCGGAGGAGCACTGGTCGCTCCCTCGGCCGGCACACCCGTAGGGCCT
TGGCTACGAACTGGCGACTCGGGCTTCGTGTCTGAGGACAAGTTTTTCATCATCGGCAGA
ATAAAGGATCTGTTGATTGTTTACGGCCGCAATCATTCTCCCGACGACATCGAGGCAACG
ATCCAGGAGATCACTCGGGGCCGCTGTGCGGCGATAGCGGTTCCGAGCAATGGCGTGGAG
AAGCTCGTTGCCATCGTCGAACTCAACAACCGCGGCAACTTGGACACAGAGAGGCTGAGC
TTCGTCACGCGTGAAGTCACCTCGGCGATATCCACCTCGCATGGATTGAGCGTGTCGGAT
CTGGTTCTGGTGGCGCCCGGCTCGATTCCGATCACCACGAGCGGCAAGGTCAGACGTGCC
GAGTGTGTGAAGCTGTATCGACACAACGAGTTCACCCGGTTGGACGCTAAGCCGTTGCAA
GCGAGCGATCTTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3827c	active	ashwinigbhat	2012-10-05
	Affinity purification (Physical interaction) J. Lynett & RW. Stokes Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading, Engl.) 2007
Interaction	PhysicalInteraction Rv3827c	active	priti.priety	2012-10-05
	Affinity purification (Physical interaction) J. Lynett & RW. Stokes Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading, Engl.) 2007
Interaction	Transcription Rv1221	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) authors,KT. Schricker [Prevention and therapy of disorders of pulmonary microcirculation]. Klin Anasthesiol Intensivther 1979
Interaction	Transcription Rv1221	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) J. Lynett & RW. Stokes Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading, Engl.) 2007
Interaction	Transcription Rv1221	active	priti.priety	2012-10-05
	Co-expression (Functional linkage) authors,KT. Schricker [Prevention and therapy of disorders of pulmonary microcirculation]. Klin Anasthesiol Intensivther 1979
Interaction	Transcription Rv1221	active	priti.priety	2012-10-05
	Co-expression (Functional linkage) J. Lynett & RW. Stokes Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading, Engl.) 2007
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. PA. Fontán, V. Aris et al. Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. J. Infect. Dis. 2008
Name	Probable fatty-acyl AMP ligase responsible for providing the long-chain fatty acid starter unit to Pks2 for the generation of phthioceranic and hydroxyphthioceranic acids	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Other	TBPWY:Polymethyl-branched acyltrehaloses	active	mjackson	2012-03-05
	Probable fatty-acyl AMP ligase responsible for providing the long-chain fatty acid starter unit to Pks2 for the generation of phthioceranic and hydroxyphthioceranic acids