Rv3877 - conserved membrane protein

Expression: Most Significant Conditions for Rv3877

Protein Domains

Gene Information
Locus	Rv3877
Symbol
Gene Name	conserved membrane protein
Location	4355007 - 4356542 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1536 bp Protein:512 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	19822
Related Genes	Mkms_0082 ML0047 Mmcs_0073 MSMEG_0068 MT3991 Mvan_0081
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3877
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3877 Transcript 1
MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLE
DTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLV
EDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGIL
GIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATA
VLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAA
KLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTER
SKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCA
WALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRT
LELIDGAMIAAIIPMLLWITGVYDTVRNIRF*

Genomic Sequence

>Rv3877
TTGAGCGCACCTGCTGTTGCTGCTGGTCCTACCGCCGCGGGGGCAACCGCTGCGCGGCCT
GCCACCACCCGGGTGACGATCCTGACCGGCAGACGGATGACCGATTTGGTACTGCCAGCG
GCGGTGCCGATGGAAACTTATATTGACGACACCGTCGCGGTGCTTTCCGAGGTGTTGGAA
GACACGCCGGCTGATGTACTCGGCGGCTTCGACTTTACCGCGCAAGGCGTGTGGGCGTTC
GCTCGTCCCGGATCGCCGCCGCTGAAGCTCGACCAGTCACTCGATGACGCCGGGGTGGTC
GACGGGTCACTGCTGACTCTGGTGTCAGTCAGTCGCACCGAGCGCTACCGACCGTTGGTC
GAGGATGTCATCGACGCGATCGCCGTGCTTGACGAGTCACCTGAGTTCGACCGCACGGCA
TTGAATCGCTTTGTGGGGGCGGCGATCCCGCTTTTGACCGCGCCCGTCATCGGGATGGCG
ATGCGGGCGTGGTGGGAAACTGGGCGTAGCTTGTGGTGGCCGTTGGCGATTGGCATCCTG
GGGATCGCTGTGCTGGTAGGCAGCTTCGTCGCGAACAGGTTCTACCAGAGCGGCCACCTG
GCCGAGTGCCTACTGGTCACGACGTATCTGCTGATCGCAACCGCCGCAGCGCTGGCCGTG
CCGTTGCCGCGCGGGGTCAACTCGTTGGGGGCGCCACAAGTTGCCGGCGCCGCTACGGCC
GTGCTGTTTTTGACCTTGATGACGCGGGGCGGCCCTCGGAAGCGTCATGAGTTGGCGTCG
TTTGCCGTGATCACCGCTATCGCGGTCATCGCGGCCGCCGCTGCCTTCGGCTATGGATAC
CAGGACTGGGTCCCCGCGGGGGGGATCGCATTCGGGCTGTTCATTGTGACGAATGCGGCC
AAGCTGACCGTCGCGGTCGCGCGGATCGCGCTGCCGCCGATTCCGGTACCCGGCGAAACC
GTGGACAACGAGGAGTTGCTCGATCCCGTCGCGACCCCGGAGGCTACCAGCGAAGAAACC
CCGACCTGGCAGGCCATCATCGCGTCGGTGCCCGCGTCCGCGGTCCGGCTCACCGAGCGC
AGCAAACTGGCCAAGCAACTTCTGATCGGATACGTCACGTCGGGCACCCTGATTCTGGCT
GCCGGTGCCATCGCGGTCGTGGTGCGCGGGCACTTCTTTGTACACAGCCTGGTGGTCGCG
GGTTTGATCACGACCGTCTGCGGATTTCGCTCGCGGCTTTACGCCGAGCGCTGGTGTGCG
TGGGCGTTGCTGGCGGCGACGGTCGCGATTCCGACGGGTCTGACGGCCAAACTCATCATC
TGGTACCCGCACTATGCCTGGCTGTTGTTGAGCGTCTACCTCACGGTAGCCCTGGTTGCG
CTCGTGGTGGTCGGGTCGATGGCTCACGTCCGGCGCGTTTCACCGGTCGTAAAACGAACT
CTGGAATTGATCGACGGCGCCATGATCGCTGCCATCATTCCCATGCTGCTGTGGATCACC
GGGGTGTACGACACGGTCCGCAATATCCGGTTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3849	active	sourish10	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3849	active	sourish10	2012-10-05
	Co-expression (Functional linkage) S. Raghavan, P. Manzanillo et al. Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature 2008
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	PhysicalInteraction Rv3869	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3869	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006