Rv0013 - anthranilate synthase component II trpG

Expression: Most Significant Conditions for Rv0013

Protein Domains

Gene Information
Locus	Rv0013
Symbol	trpG
Gene Name	anthranilate synthase component II trpG
Location	14914 - 15612 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:699 bp Protein:233 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	36222
Related Genes	CE1059 cg1134 DIP1790 jk0031 jk0036 MAP0015 MAV_0018 Mkms_0022 ML0015 Mmcs_0014 MSMEG_0029 MT0016 MUL_0017 Mvan_0022 nfa770
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0013
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0013 Transcript 1
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGVLLSPGPGTPE
RAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQ
GLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTGLPIHGVQFHPESILTEG
GHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA*

Genomic Sequence

>Rv0013
ATGCGGATCCTGGTCGTTGACAACTACGACAGCTTCGTGTTCAACCTGGTGCAGTACCTC
GGCCAGCTCGGCATCGAGGCCGAGGTGTGGCGCAACGACGACCACCGGCTATCCGATGAG
GCCGCCGTCGCCGGCCAATTCGACGGTGTCCTGCTCAGTCCCGGTCCGGGTACCCCGGAG
CGCGCGGGCGCGTCGGTGAGTATCGTGCACGCGTGTGCGGCAGCACACACCCCTTTGCTG
GGGGTCTGCCTTGGGCACCAAGCCATCGGCGTTGCGTTCGGCGCCACCGTGGACCGTGCG
CCCGAGCTATTGCACGGCAAGACCAGCAGCGTATTCCACACCAATGTCGGTGTGCTACAA
GGGCTTCCGGATCCCTTCACGGCCACTCGATACCATTCGTTGACAATTCTGCCTAAGTCG
CTGCCAGCGGTGCTGAGGGTCACGGCCCGCACTAGCAGCGGTGTGATCATGGCCGTGCAG
CACACCGGGCTGCCGATCCACGGTGTCCAGTTCCATCCGGAGTCGATTCTCACCGAGGGC
GGGCACCGCATACTGGCCAACTGGCTCACCTGCTGCGGATGGACGCAAGACGACACCCTG
GTACGTCGGCTGGAAAACGAAGTGCTCACCGCCATCTCACCGCACTTCCCAACTTCAACC
GCTAGCGCGGGCGAAGCTACTGGCCGAACCTCAGCGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv1005c	active	shahanup86	2012-10-05
	Co-occurrence (Functional linkage) authors,J. Slock,DP. Stahly,CY. Han,EW. Six,IP. Crawford An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene. J. Bacteriol. 1990
Interaction	PhysicalInteraction Rv1005c	active	shahanup86	2012-10-05
	Co-occurrence (Functional linkage) authors,BP. Nichols,AM. Seibold,SZ. Doktor para-aminobenzoate synthesis from chorismate occurs in two steps. J. Biol. Chem. 1989
Interaction	PhysicalInteraction Rv1005c	active	shahanup86	2012-10-05
	Co-occurrence (Functional linkage) AJ. Harrison, M. Yu et al. The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J. Bacteriol. 2006
Interaction	PhysicalInteraction Rv1609	active	shahanup86	2012-10-05
	X. Lin, S. Xu et al. Purification and characterization of anthranilate synthase component I (TrpE) from Mycobacterium tuberculosis H37Rv. Protein Expr. Purif. 2009
Interaction	PhysicalInteraction Rv1609	active	shahanup86	2012-10-05
	AJ. Harrison, RJ. Ramsay et al. Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005