Rv0249c - succinate dehydrogenase membrane anchor subunit

Expression: Most Significant Conditions for Rv0249c

Protein Domains

Gene Information
Locus	Rv0249c
Symbol
Gene Name	succinate dehydrogenase membrane anchor subunit
Location	300834 - 301655 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:822 bp Protein:274 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	2770
Related Genes	Acel_1866 MAP3699c MAV_4908 Mkms_0264 Mmcs_0254 MSMEG_0419 MT0263 MUL_1173 Mvan_0287 nfa56010 SAV3180
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0249c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0249c Transcript 1
MSAPTANRPAIGVFTPTRAQIPERTLRTDLWWLPPLLTNLGLLAFICYATTRAFWGSQYW
VEKYHYLTPFYSPCVSASCQPGASHLGVWFGHFPGWIPLGAMVLPFLLGFRLTCYYYRKA
YYRSVWQSPTSCAVPEPRAHYTGETRLPLIVQNTHRYFFYIAVVVSLINTYDAIAAFHSP
SGFGFGLGNVILTINVVLLWAYTISCHSCRHATGGRLKHFSKHPVRYWIWTQVSKLNTRH
MQFAWITLGTLALTDFYIMLVASGSITDLRFIG*

Genomic Sequence

>Rv0249c
ATGAGCGCACCCACGGCGAACCGTCCTGCGATCGGCGTTTTCACACCCACCCGCGCACAA
ATCCCAGAACGGACGCTTCGCACCGACCTCTGGTGGTTGCCACCGCTGCTGACCAACCTC
GGTCTTTTGGCGTTCATCTGCTATGCGACCACTCGGGCGTTCTGGGGCAGCCAATACTGG
GTGGAAAAATATCATTACCTGACGCCGTTCTACTCGCCGTGCGTCAGCGCGTCCTGCCAG
CCCGGCGCCAGTCATCTCGGCGTCTGGTTCGGGCATTTTCCAGGGTGGATTCCGTTGGGA
GCGATGGTATTACCGTTCCTGCTTGGATTCCGGCTCACCTGCTATTATTACCGCAAGGCC
TACTACCGGTCGGTATGGCAGTCGCCGACAAGCTGCGCAGTGCCCGAGCCGCGGGCTCAT
TACACCGGTGAAACCCGGCTTCCGCTGATCGTCCAGAACACCCACCGGTATTTCTTCTAT
ATCGCGGTGGTGGTGTCGCTGATCAACACCTATGACGCGATCGCGGCATTTCACTCGCCG
TCCGGATTCGGCTTCGGTTTGGGCAATGTCATTTTGACGATCAATGTGGTTCTGCTGTGG
GCATACACCATCTCGTGCCATTCGTGCCGGCACGCCACCGGCGGTCGGCTCAAGCATTTC
TCCAAGCACCCAGTGCGATACTGGATCTGGACACAGGTCAGCAAGCTCAATACCCGACAC
ATGCAATTCGCGTGGATCACGCTGGGGACCCTGGCGCTCACCGATTTCTACATCATGCTG
GTGGCCAGTGGCAGCATCACAGATCTCAGATTTATTGGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift M. Stapleton, I. Haq et al. Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties. J. Biol. Chem. 2010
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv0250c	active	sourish10	2012-10-05
	Operon (Functional linkage) GR. Stewart, L. Wernisch et al. Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. Microbiology (Reading, Engl.) 2002
Interaction	Operon Rv0248c	active	singhpankaj2116	2012-10-05
	operon authors,M. Berney,GM. Cook Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS ONE 2010
Interaction	Operon Rv0248c	active	singhpankaj2116	2012-10-05
	operon T. Kurokawa & J. Sakamoto Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum. Arch. Microbiol. 2005
Interaction	Operon Rv0247c	active	singhpankaj2116	2012-10-05
	operon authors,M. Berney,GM. Cook Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS ONE 2010
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008