Rv0350 - chaperone protein dnaK

Expression: Most Significant Conditions for Rv0350

Protein Domains

Gene Information
Locus	Rv0350
Symbol	dnaK
Gene Name	chaperone protein dnaK
Location	419835 - 421712 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1878 bp Protein:626 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32906
Related Genes	Acel_2115 BL0520 CE2629 cg3100 DIP2120 jk0179 MAP3840 MAV_4808 Mkms_0473 ML2496 Mmcs_0462 MSMEG_0709 MT0365 MUL_0593 Mvan_0634 nfa54090 PPA2040 SAV4484 SAV7237
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0350
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0350 Transcript 1
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVT
NVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPA
YFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSL
LEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEK
AKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADT
GISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEV
KDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGERE
IAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSG
LSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDT
LNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGE
PGGAHPGSADDVVDAEVVDDGREAK*

Genomic Sequence

>Rv0350
ATGGCTCGTGCGGTCGGGATCGACCTCGGGACCACCAACTCCGTCGTCTCGGTTCTGGAA
GGTGGCGACCCGGTCGTCGTCGCCAACTCCGAGGGCTCCAGGACCACCCCGTCAATTGTC
GCGTTCGCCCGCAACGGTGAGGTGCTGGTCGGCCAGCCCGCCAAGAACCAGGCAGTGACC
AACGTCGATCGCACCGTGCGCTCGGTCAAGCGACACATGGGCAGCGACTGGTCCATAGAG
ATTGACGGCAAGAAATACACCGCGCCGGAGATCAGCGCCCGCATTCTGATGAAGCTGAAG
CGCGACGCCGAGGCCTACCTCGGTGAGGACATTACCGACGCGGTTATCACGACGCCCGCC
TACTTCAATGACGCCCAGCGTCAGGCCACCAAGGACGCCGGCCAGATCGCCGGCCTCAAC
GTGCTGCGGATCGTCAACGAGCCGACCGCGGCCGCGCTGGCCTACGGCCTCGACAAGGGC
GAGAAGGAGCAGCGAATCCTGGTCTTCGACTTGGGTGGTGGCACTTTCGACGTTTCCCTG
CTGGAGATCGGCGAGGGTGTGGTTGAGGTCCGTGCCACTTCGGGTGACAACCACCTCGGC
GGCGACGACTGGGACCAGCGGGTCGTCGATTGGCTGGTGGACAAGTTCAAGGGCACCAGC
GGCATCGATCTGACCAAGGACAAGATGGCGATGCAGCGGCTGCGGGAAGCCGCCGAGAAG
GCAAAGATCGAGCTGAGTTCGAGTCAGTCCACCTCGATCAACCTGCCCTACATCACCGTC
GACGCCGACAAGAACCCGTTGTTCTTAGACGAGCAGCTGACCCGCGCGGAGTTCCAACGG
ATCACTCAGGACCTGCTGGACCGCACTCGCAAGCCGTTCCAGTCGGTGATCGCTGACACC
GGCATTTCGGTGTCGGAGATCGATCACGTTGTGCTCGTGGGTGGTTCGACCCGGATGCCC
GCGGTGACCGATCTGGTCAAGGAACTCACCGGCGGCAAGGAACCCAACAAGGGCGTCAAC
CCCGATGAGGTTGTCGCGGTGGGAGCCGCTCTGCAGGCCGGCGTCCTCAAGGGCGAGGTG
AAAGACGTTCTGCTGCTTGATGTTACCCCGCTGAGCCTGGGTATCGAGACCAAGGGCGGG
GTGATGACCAGGCTCATCGAGCGCAACACCACGATCCCCACCAAGCGGTCGGAGACTTTC
ACCACCGCCGACGACAACCAACCGTCGGTGCAGATCCAGGTCTATCAGGGGGAGCGTGAG
ATCGCCGCGCACAACAAGTTGCTCGGGTCCTTCGAGCTGACCGGCATCCCGCCGGCGCCG
CGGGGGATTCCGCAGATCGAGGTCACTTTCGACATCGACGCCAACGGCATTGTGCACGTC
ACCGCCAAGGACAAGGGCACCGGCAAGGAGAACACGATCCGAATCCAGGAAGGCTCGGGC
CTGTCCAAGGAAGACATTGACCGCATGATCAAGGACGCCGAAGCGCACGCCGAGGAGGAT
CGCAAGCGTCGCGAGGAGGCCGATGTTCGTAATCAAGCCGAGACATTGGTCTACCAGACG
GAGAAGTTCGTCAAAGAACAGCGTGAGGCCGAGGGTGGTTCGAAGGTACCTGAAGACACG
CTGAACAAGGTTGATGCCGCGGTGGCGGAAGCGAAGGCGGCACTTGGCGGATCGGATATT
TCGGCCATCAAGTCGGCGATGGAGAAGCTGGGCCAGGAGTCGCAGGCTCTGGGGCAAGCG
ATCTACGAAGCAGCTCAGGCTGCGTCACAGGCCACTGGCGCTGCCCACCCCGGCGGCGAG
CCGGGCGGTGCCCACCCCGGCTCGGCTGATGACGTTGTGGACGCGGAGGTGGTCGACGAC
GGCCGGGAGGCCAAGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv1354c	active	jgalag	2012-10-05
	Yeast two-hybrid (Physical interaction) T. Cui, L. Zhang et al. Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis. BMC Genomics 2009
Interaction	Regulatory Rv0353	active	dimpi.srcp	2012-10-05
	Band Shift authors,I. Smith Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin. Microbiol. Rev. 2003
Interaction	Regulatory Rv0353	active	dimpi.srcp	2012-10-05
	Band Shift T. Das Gupta, B. Bandyopadhyay et al. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Microbiology (Reading, Engl.) 2008
Interaction	Regulatory Rv0352	active	dimpi.srcp	2012-10-05
	Co-expression (Functional linkage) GR. Stewart, BD. Robertson et al. Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling. Tuberculosis (Edinburgh, Scotland) 2004
Interaction	Regulatory Rv0351	active	ilamathi.raja	2012-10-05
	Band Shift T. Das Gupta, B. Bandyopadhyay et al. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Microbiology (Reading, Engl.) 2008
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Co occurance (Functional Linkage) authors,MA. Zmijewski,JM. Kwiatkowska,B. LipiDska Complementation studies of the DnaK-DnaJ-GrpE chaperone machineries from Vibrio harveyi and Escherichia coli, both in vivo and in vitro. Arch. Microbiol. 2004
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Co occurance (Functional Linkage) T. Das Gupta, B. Bandyopadhyay et al. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Microbiology (Reading, Engl.) 2008
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Co occurance (Functional Linkage) TB. Hickey, LM. Thorson et al. Mycobacterium tuberculosis Cpn60.2 and DnaK are Located on the Bacterial Surface, where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages. Infect. Immun. 2009
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Gene Neighborhood (Functional Linkage) authors,MA. Zmijewski,JM. Kwiatkowska,B. LipiDska Complementation studies of the DnaK-DnaJ-GrpE chaperone machineries from Vibrio harveyi and Escherichia coli, both in vivo and in vitro. Arch. Microbiol. 2004
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Gene Neighborhood (Functional Linkage) T. Das Gupta, B. Bandyopadhyay et al. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Microbiology (Reading, Engl.) 2008
Interaction	Signaling Rv0353	active	shahanup86	2012-10-05
	Gene Neighborhood (Functional Linkage) TB. Hickey, LM. Thorson et al. Mycobacterium tuberculosis Cpn60.2 and DnaK are Located on the Bacterial Surface, where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages. Infect. Immun. 2009
Interaction	Regulatory Rv0182c	active	priti.priety	2012-10-05
	Co-expression (Functional linkage) JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3133c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2034	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0491	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3223c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv0353	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008