Rv0384c - endopeptidase ATP binding protein chain B clpB

Expression: Most Significant Conditions for Rv0384c

Protein Domains

Gene Information
Locus	Rv0384c
Symbol	clpB
Gene Name	endopeptidase ATP binding protein chain B clpB
Location	459456 - 462002 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2547 bp Protein:849 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32998
Related Genes	Acel_2119 BL1250 CE2613 cg3079 DIP2104 jk0201 MAP3853 MAV_4793 Mkms_0489 ML2490 Mmcs_0478 MSMEG_0732 MT0397 MUL_0127 Mvan_0659 nfa54020 SAV4514 SAV7241
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0384c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0384c Transcript 1
MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGIAAPLLEAVGVEPATV
RAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELDDEYVSTEHVMVGLATGDS
DVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQALQKYSTDLTARAREGKLDPV
IGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTIVAL
DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMI
KPMLARGELRLVGATTLDEYRKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEV
HHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLV
RRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQNEKNAIEIVRDLKEQL
EALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAALPQAQAREQVMLKEEVGPDDIAD
VVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPT
GAFMFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEA
GGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTS
NLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRR
LQLQVSLPAKRWLAQRGFDPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSP
DADSLILG*

Genomic Sequence

>Rv0384c
GTGGACTCGTTTAACCCGACGACCAAGACGCAGGCGGCGCTAACCGCGGCGTTACAGGCG
GCTTCGACCGCCGGCAATCCCGAGATCCGGCCCGCTCACCTGCTGATGGCGCTGCTGACC
CAAAACGACGGTATCGCCGCACCGCTACTGGAGGCTGTCGGTGTCGAGCCCGCCACCGTC
CGCGCCGAAACCCAGCGCCTGCTCGACCGTTTGCCGCAGGCGACTGGAGCCAGCACGCAG
CCGCAGCTGTCCCGCGAGTCGTTAGCGGCGATCACCACCGCGCAGCAGCTGGCCACCGAG
CTGGACGACGAGTACGTCTCCACCGAGCACGTGATGGTCGGGCTGGCCACCGGTGACTCC
GACGTCGCCAAGCTGTTGACCGGCCACGGCGCCTCGCCGCAGGCGCTGCGGGAGGCGTTC
GTCAAGGTGCGCGGCAGCGCCCGGGTCACCAGCCCCGAACCGGAGGCGACCTATCAGGCG
CTGCAGAAGTACTCCACCGACCTGACCGCCCGCGCCCGCGAAGGCAAACTCGACCCGGTC
ATCGGCCGCGACAACGAGATCCGCCGCGTGGTGCAGGTGCTGTCCCGTCGCACCAAGAAC
AACCCGGTGCTGATCGGTGAGCCCGGCGTCGGCAAGACCGCGATCGTGGAGGGCCTGGCG
CAGCGCATCGTGGCCGGCGACGTGCCGGAGAGCTTGCGCGACAAGACCATCGTCGCGCTC
GATCTCGGCTCGATGGTCGCCGGCTCCAAATACCGCGGCGAATTCGAGGAACGGCTCAAG
GCCGTCCTCGACGACATCAAGAACTCGGCCGGCCAAATCATCACGTTCATCGACGAGCTG
CACACCATCGTCGGCGCCGGCGCCACCGGCGAGGGGGCGATGGACGCCGGCAACATGATC
AAGCCGATGCTGGCCCGCGGCGAGTTACGGCTGGTCGGGGCGACCACGCTGGACGAATAC
CGCAAGCACATCGAGAAGGACGCCGCGCTCGAGCGCCGTTTCCAACAGGTGTACGTCGGC
GAGCCGTCGGTGGAGGACACCATCGGCATCCTGCGCGGGCTCAAAGACCGCTACGAGGTG
CACCACGGGGTGCGCATCACCGACTCGGCGCTGGTGGCAGCTGCCACTTTGAGCGACCGG
TATATCACCGCCCGCTTCCTGCCCGACAAGGCCATCGACCTGGTCGACGAGGCGGCCAGC
CGGCTGCGGATGGAGATCGACTCGCGGCCCGTCGAGATCGACGAGGTCGAGCGGCTGGTG
CGCCGGCTGGAGATCGAAGAGATGGCGCTGTCCAAAGAAGAAGACGAGGCGTCGGCGGAG
CGGTTGGCCAAGCTGCGCTCCGAGCTGGCCGACCAGAAAGAGAAGTTGGCCGAGCTCACC
ACCCGCTGGCAGAACGAGAAGAACGCGATCGAAATCGTCCGCGACCTCAAGGAGCAGCTG
GAAGCCCTGCGCGGGGAATCCGAGCGGGCCGAACGCGACGGCGACCTGGCCAAGGCCGCC
GAGCTGCGCTACGGACGCATCCCCGAGGTGGAGAAGAAGCTCGACGCGGCGTTGCCGCAG
GCGCAGGCCCGGGAGCAGGTGATGCTCAAGGAGGAGGTCGGTCCCGACGACATCGCCGAC
GTGGTGTCGGCGTGGACCGGCATCCCGGCCGGTCGGCTGCTGGAAGGCGAGACCGCCAAG
CTGCTGCGCATGGAAGACGAGCTGGGCAAGCGGGTCATCGGGCAGAAGGCCGCGGTTACC
GCAGTCTCTGATGCGGTGCGGCGCAGCCGGGCCGGGGTGTCCGACCCCAACCGGCCCACC
GGGGCGTTCATGTTCCTCGGCCCGACCGGTGTCGGCAAGACCGAGCTGGCCAAGGCGCTG
GCCGACTTCCTGTTCGACGACGAGCGGGCGATGGTCCGCATCGACATGAGCGAGTACGGC
GAGAAGCACACCGTGGCTCGGTTGATCGGCGCCCCGCCCGGCTATGTGGGATACGAGGCG
GGCGGTCAGCTGACCGAGGCGGTGCGCCGGCGTCCCTACACGGTGGTGCTGTTCGACGAG
ATCGAGAAGGCGCACCCGGACGTGTTCGACGTGCTGCTGCAGGTCCTCGACGAGGGCCGG
CTCACCGACGGGCACGGCCGCACGGTCGACTTCCGCAACACCATCTTGATCCTGACGTCC
AACCTGGGGTCGGGTGGCAGCGCCGAGCAGGTGCTGGCCGCGGTGCGCGCTACGTTCAAG
CCGGAGTTCATCAACCGGCTCGACGACGTGCTCATCTTTGAGGGTCTCAACCCCGAAGAG
CTGGTGCGCATCGTCGACATCCAGCTGGCGCAGCTGGGCAAGCGGCTGGCGCAGCGGCGG
CTGCAGCTGCAGGTCTCGCTGCCGGCCAAGCGCTGGTTGGCGCAGCGCGGATTCGACCCG
GTGTACGGGGCGCGGCCGTTGCGCCGGCTGGTGCAGCAGGCCATCGGTGACCAGCTGGCC
AAGATGCTGTTGGCCGGCCAGGTGCACGACGGCGATACCGTGCCGGTCAACGTCAGCCCC
GACGCCGACTCGCTGATCCTGGGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Inhibits Rv1222	active	harsharohiratruefriend	2012-10-05
	affinity purification R. Manganelli,R. Provvedi,S. Rodrigue,J. Beaucher,L. Gaudreau,I. Smith,R. Proveddi Sigma factors and global gene regulation in Mycobacterium tuberculosis. J. Bacteriol. 2004
Interaction	Inhibits Rv1222	active	harsharohiratruefriend	2012-10-05
	affinity purification S. Barik, K. Sureka et al. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol. Microbiol. 2010
Interaction	Regulatory Rv3223c	active	manish.srcp	2012-10-05
	Co-expression (Functional linkage) PA. Fontán,MI. Voskuil,M. Gomez,D. Tan,M. Pardini,R. Manganelli,L. Fattorini,GK. Schoolnik,I. Smith The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth. J. Bacteriol. 2009
Interaction	Regulatory Rv3223c	active	manish.srcp	2012-10-05
	Co-expression (Functional linkage) S. Raman, T. Song et al. The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. J. Bacteriol. 2001
Interaction	Regulatory Rv0182c	active	priti.priety	2012-10-05
	Co-expression (Functional linkage) JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv3223c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv0353	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008