Rv0407 - F420-dependent glucose-6-phosphate dehydrogenase fgd1

Expression: Most Significant Conditions for Rv0407

Protein Domains

Gene Information
Locus	Rv0407
Symbol	fgd1
Gene Name	F420-dependent glucose-6-phosphate dehydrogenase fgd1
Location	490783 - 491793 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1011 bp Protein:337 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	20308
Related Genes	MAP3884 MAV_4761 Mkms_0544 ML0269 Mmcs_0532 MSMEG_0777 MT0420 MUL_2814 Mvan_0698 nfa53550
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0407
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0407 Transcript 1
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTA
VGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEG
AWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPA
VAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPE
LALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQY
VTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG*

Genomic Sequence

>Rv0407
GTGGCTGAACTGAAGCTAGGTTACAAAGCATCGGCCGAACAATTCGCACCGCGCGAGCTC
GTCGAACTAGCCGTCGCCGCCGAAGCCCACGGCATGGACAGCGCGACCGTCAGCGACCAT
TTTCAGCCTTGGCGCCACCAGGGCGGCCATGCCCCGTTCTCGCTGTCCTGGATGACCGCT
GTCGGCGAACGTACCAACCGGCTGCTGCTGGGCACTTCGGTGCTGACCCCCACCTTCCGC
TACAACCCCGCCGTCATCGCTCAGGCTTTCGCCACCATGGGATGCCTGTACCCGAACCGT
GTTTTCCTTGGCGTGGGCACCGGTGAGGCGCTGAACGAAATCGCCACCGGATACGAGGGC
GCCTGGCCGGAGTTCAAGGAGCGGTTCGCCCGGCTGCGTGAATCGGTGGGGCTAATGCGG
CAGCTGTGGAGCGGTGACCGCGTCGACTTTGACGGCGACTATTACCGGCTCAAGGGTGCC
TCGATCTACGACGTGCCCGACGGGGGCGTGCCCGTCTACATCGCCGCCGGCGGCCCGGCG
GTGGCCAAGTACGCCGGCCGCGCCGGTGACGGCTTCATCTGTACGTCCGGCAAGGGCGAG
GAGCTCTACACCGAGAAGCTGATGCCGGCGGTACGAGAAGGCGCCGCTGCCGCTGACCGA
TCCGTCGACGGCATCGACAAGATGATCGAAATCAAGATCTCCTACGACCCCGACCCGGAG
CTGGCATTGAACAACACCCGGTTTTGGGCGCCGCTGTCGTTGACAGCTGAGCAGAAGCAC
AGCATCGACGACCCGATCGAGATGGAGAAGGCCGCCGATGCGCTGCCAATCGAACAGATC
GCCAAGCGCTGGATCGTGGCGTCGGACCCCGACGAAGCCGTCGAAAAGGTAGGTCAATAC
GTGACATGGGGCCTGAACCACCTGGTATTTCACGCACCAGGACATGACCAGCGCCGGTTT
CTGGAGCTCTTCCAGTCGGACCTGGCACCCAGGTTGCGGCGACTTGGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Other	EC:1.1.98.2	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype G. Bashiri, CJ. Squire et al. Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding. J. Biol. Chem. 2008
Other	EC:1.1.98.2	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011