Rv0462 - dihydrolipoamide dehydrogenase lpd
Protein Domains

Gene Information
LocusRv0462
Symbollpd
Gene Namedihydrolipoamide dehydrogenase lpd
Location552614 - 554008 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1395 bp
Protein:465 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number37894
Related GenesCE0383 cg0441 DIP0368 jk1936 MAP3956 MAV_4687 Mkms_0644 ML2387 Mmcs_0631 MSMEG_0903 MT0478 MUL_2214 Mvan_0794 nfa52650
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:PDH pyruvate dehydrogenase - ISSactivenjamshidi2012-10-05
previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627.
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
TermTBRXN:PDH pyruvate dehydrogenase - IDAactivenjamshidi2012-10-05
previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627.
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionPhysicalInteraction Rv2215activepriyadarshinipriyanka20012012-10-05
Affinity purification (Physical interaction)
J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
InteractionPhysicalInteraction Rv2429activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv2428activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv2429activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionPhysicalInteraction Rv2428activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionPhysicalInteraction Rv2429activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv2428activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv2429activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionPhysicalInteraction Rv2428activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionRegulatedBy Rv3676activeyamir.moreno2012-10-05
E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
InteractionRegulatedBy Rv3676activeyamir.moreno2012-10-05
E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
TermEC:1.8.1.4 Dihydrolipoyl dehydrogenase. - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
TermEC:1.8.1.4 Dihydrolipoyl dehydrogenase. - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
TermEC:1.8.1.4 Dihydrolipoyl dehydrogenase. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001