Rv0642c - methoxy mycolic acid synthase 4 mmaA4
Protein Domains

Gene Information
LocusRv0642c
SymbolmmaA4
Gene Namemethoxy mycolic acid synthase 4 mmaA4
Location736298 - 737203 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:906 bp
Protein:302 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number25907
Related GenesMAP4116c MAV_4517 ML1903 MT0670 MUL_0729
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:MYC1M2 Mycolic Acid Methyl Hydroxyl Addition - ISSactivenjamshidi2012-10-05
PMID: 16356931
F. Boissier, F. Bardou et al. Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
TermTBRXN:MYC1M2 Mycolic Acid Methyl Hydroxyl Addition - IDAactivenjamshidi2012-10-05
PMID: 16356931
F. Boissier, F. Bardou et al. Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
TermTBRXN:MYC1M1 Mycolic Acid Methyl Hydroxyl Addition - ISSactivenjamshidi2012-10-05
PMID: 16356931
F. Boissier, F. Bardou et al. Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
TermTBRXN:MYC1M1 Mycolic Acid Methyl Hydroxyl Addition - IDAactivenjamshidi2012-10-05
PMID: 16356931
F. Boissier, F. Bardou et al. Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
NameMmaA4 METHOXY MYCOLIC ACID SYNTHASE 4; synthesis of oxygenated mycolatesactivemjackson2012-10-05
S-adenosyl-methionine-dependent mycolic acid methyltransferases
TermEC:2.1.1.79 Cyclopropane-fatty-acyl-phospholipid synthase. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
authors,P. Dinadayala,F. Laval,C. Raynaud,A. Lemassu,MA. Laneelle,G. Laneelle,M. Daffe Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates. J. Biol. Chem. 2003
TermEC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
authors,P. Dinadayala,F. Laval,C. Raynaud,A. Lemassu,MA. Laneelle,G. Laneelle,M. Daffe Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates. J. Biol. Chem. 2003
TermEC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005