Rv1160 - mutator protein mutT

Expression: Most Significant Conditions for Rv1160

Protein Domains

Gene Information
Locus	Rv1160
Symbol	mutT2
Gene Name	mutator protein mutT
Location	1286595 - 1287020 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:426 bp Protein:142 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	38048
Related Genes	Acel_1863 cg1303 DIP1017 MAP2621c MAV_1301 Mkms_4118 Mmcs_4043 MSMEG_5143 MSMEG_5148 MT1197 MUL_1008 Mvan_2545 Mvan_4548 SAV3187
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1160
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1160 Transcript 1
MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLE
VADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADR
GWIADLARTLNGSAADVHRRC*

Genomic Sequence

>Rv1160
ATGCTGAATCAGATCGTGGTTGCCGGAGCCATCGTCCGCGGTTGCACGGTCTTGGTGGCG
CAACGCGTTCGGCCACCGGAGTTGGCGGGTCGTTGGGAACTTCCCGGCGGTAAGGTCGCC
GCCGGCGAAACCGAGCGCGCCGCGCTGGCCCGAGAGCTCGCCGAAGAACTGGGACTCGAG
GTCGCCGACCTCGCGGTGGGCGACCGTGTGGGCGACGATATTGCGTTGAACGGCACGACG
ACGCTGCGGGCCTATCGCGTGCATCTGCTTGGCGGCGAACCGCGTGCGCGTGACCACCGG
GCGCTGTGCTGGGTGACGGCGGCCGAACTGCACGATGTCGACTGGGTACCAGCCGACCGC
GGCTGGATTGCGGACCTGGCGCGAACCCTCAACGGGTCCGCCGCAGATGTCCACCGTCGC
TGTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Other	TBPWY:Nucleotide pool	active	vmizrahi	2012-03-05
	MutT2 has a preference for cytidine triphosphates, and although the G58R mutation does not alter nucleotide specificity, it reduces the protein's affinity for divalent cations. The K(D) of free Mg(2+) is 79-fold higher for the G58R mutant (3.30 +/- 0.19 mM) compared with that for the wild-type (41.7 +/- 1.4 mM). A role for MutT2 in the regulation of cytidine-triphosphates available for nucleotide-dependent reactions is postulated
Other	TBPWY:Nucleotide pool	active	vmizrahi	2012-03-05
	Mutant constructed and charaterised. An 8-oxo-guanosine triphosphatase function suggested