Rv1170 - N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase mshB

Expression: Most Significant Conditions for Rv1170

Protein Domains

Gene Information
Locus	Rv1170
Symbol	mshB
Gene Name	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase mshB
Location	1300304 - 1301215 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:912 bp Protein:304 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	18984
Related Genes	Acel_1868 CE1158 cg1250 DIP0971 jk1397 MAP2613c MAV_1310 Mkms_4109 ML1495 Mmcs_4034 MSMEG_5129 MT1207 MUL_1017 Mvan_4535 nfa47570 SAV3138
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1170
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1170 Transcript 1
MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVHVVTCTLGEEGEVIGDRWAQLTADH
ADQLGGYRIGELTAALRALGVSAPIYLGGAGRWRDSGMAGTDQRSQRRFVDADPRQTVGA
LVAIIRELRPHVVVTYDPNGGYGHPDHVHTHTVTTAAVAAAGVGSGTADHPGDPWTVPKF
YWTVLGLSALISGARALVPDDLRPEWVLPRADEIAFGYSDDGIDAVVEADEQARAAKVAA
LAAHATQVVVGPTGRAAALSNNLALPILADEHYVLAGGSAGARDERGWETDLLAGLGFTA
SGT*

Genomic Sequence

>Rv1170
ATGTCTGAGACGCCGCGGCTGCTGTTTGTTCATGCACACCCCGACGATGAGAGCCTGAGC
AACGGCGCAACCATCGCGCACTACACCTCCCGTGGCGCACAGGTCCATGTCGTCACGTGC
ACCCTGGGTGAGGAGGGCGAGGTCATTGGCGATCGCTGGGCTCAACTCACCGCCGATCAT
GCGGACCAACTCGGTGGCTACCGCATCGGCGAGCTCACCGCGGCGTTGCGAGCGCTCGGG
GTCAGCGCACCGATCTACCTTGGCGGCGCGGGTCGCTGGCGCGACTCCGGCATGGCCGGC
ACAGACCAGCGGAGTCAGCGGAGATTCGTCGATGCTGACCCCCGGCAGACCGTCGGGGCA
TTGGTCGCGATCATTCGCGAGCTGCGGCCGCATGTCGTGGTGACCTATGACCCCAATGGC
GGTTACGGTCATCCTGACCACGTGCACACCCACACCGTCACTACCGCCGCGGTGGCCGCA
GCGGGTGTTGGGTCCGGTACCGCAGATCACCCCGGCGACCCGTGGACGGTGCCGAAGTTC
TACTGGACGGTCTTGGGTCTGAGCGCGCTCATTTCGGGCGCGCGAGCCCTGGTCCCCGAC
GATCTGCGACCCGAATGGGTGTTGCCGCGGGCCGACGAGATTGCATTCGGGTACTCCGAC
GACGGTATCGACGCCGTCGTCGAGGCCGATGAGCAGGCGCGAGCCGCCAAGGTTGCGGCA
CTGGCTGCCCATGCCACCCAAGTTGTCGTCGGCCCGACCGGCCGGGCCGCCGCCTTGTCG
AACAACCTGGCACTGCCCATCCTGGCCGATGAGCATTACGTGCTCGCCGGCGGCTCCGCG
GGCGCCCGCGATGAACGTGGCTGGGAAACTGATCTGCTCGCCGGTCTGGGCTTCACCGCG
TCCGGCACGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:IGAMD 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside deacetylase - ISS	active	njamshidi	2012-10-05
	see PMID: 11092856, 14698305 AA. McCarthy, NA. Peterson et al. Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J. Mol. Biol. 2004
Term	TBRXN:IGAMD 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside deacetylase - ISS	active	njamshidi	2012-10-05
	see PMID: 11092856, 14698305 GL. Newton, Y. Av-Gay et al. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J. Bacteriol. 2000
Term	TBRXN:IGAMD 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside deacetylase - IDA	active	njamshidi	2012-10-05
	see PMID: 11092856, 14698305 AA. McCarthy, NA. Peterson et al. Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J. Mol. Biol. 2004
Term	TBRXN:IGAMD 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside deacetylase - IDA	active	njamshidi	2012-10-05
	see PMID: 11092856, 14698305 GL. Newton, Y. Av-Gay et al. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J. Bacteriol. 2000
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay GL. Newton, T. Koledin et al. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J. Bacteriol. 2003