Rv1182 - polyketide synthase associated protein papA3
Protein Domains

Gene Information
LocusRv1182
SymbolpapA3
Gene Namepolyketide synthase associated protein papA3
Location1320035 - 1321453 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1419 bp
Protein:473 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number19506
Related GenesMAP2231 MAV_1762 Mkms_0255 ML1230 Mmcs_0245 MSMEG_0409 MT1219 MUL_1531 Mvan_0270
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique.
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
NameAcyltransferase thought to transfer palmitic acid (from palmitoyl-CoA) and mycolipenic or mycosanoic acid to the 2 and 3-positions of trehalose to form 2,3-diacyltrehaloseactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
NameAcyltransferase thought to transfer palmitic acid (from palmitoyl-CoA) and mycolipenic or mycosanoic acid to the 2 and 3-positions of trehalose to form 2,3-diacyltrehaloseactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
OtherTBPWY:Polymethyl-branched acyltrehalosesactivemjackson2012-03-05
Acyltransferase thought to transfer palmitic acid (from palmitoyl-CoA) and mycolipenic or mycosanoic acid to the 2 and 3-positions of trehalose to form 2,3-diacyltrehalose (phenotypic [mycobacterial recombinant strains]; enzymatic)
SK. Hatzios, MW. Schelle et al. PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 2009
OtherEC:activejjmcfadden2012-03-05
Inferred from direct assay
VS. Dubey, TD. Sirakova et al. Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation. Mol. Microbiol. 2002