Rv1223 - serine protease htrA

Expression: Most Significant Conditions for Rv1223

Protein Domains

Gene Information
Locus	Rv1223
Symbol	htrA
Gene Name	serine protease htrA
Location	1365875 - 1367461 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1587 bp Protein:529 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34290
Related Genes	MAP2555c MAV_1366 Mkms_4066 ML1078 Mmcs_3992 MSMEG_5070 MT1261 MUL_4517 Mvan_4494 nfa47310 SAV3115 SCO5149
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1223
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1223 Transcript 1
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFG
RPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGAL
AAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLA
LGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVG
RDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPV
PLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIP
VNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST*

Genomic Sequence

>Rv1223
GTGGATACTAGGGTGGACACGGACAACGCGATGCCTGCACGTTTTAGCGCCCAGATTCAG
AATGAGGATGAGGTGACCTCCGACCAAGGCAACAACGGCGGCCCGAACGGCGGAGGCCGC
CTGGCGCCGCGCCCGGTTTTTCGGCCACCGGTCGACCCGGCGTCGCGTCAAGCGTTCGGG
CGTCCGTCCGGGGTCCAAGGGTCCTTTGTGGCCGAGCGTGTGCGCCCGCAGAAGTACCAG
GACCAGTCTGACTTCACACCGAACGATCAGCTTGCTGACCCGGTGCTTCAGGAGGCGTTC
GGTCGTCCGTTCGCGGGCGCCGAATCGCTGCAGCGCCATCCCATCGATGCCGGAGCGCTG
GCAGCTGAGAAAGACGGTGCCGGCCCCGACGAGCCCGACGATCCGTGGCGCGACCCCGCG
GCCGCGGCCGCGCTGGGGACGCCAGCGCTAGCCGCGCCGGCACCGCACGGTGCGCTGGCC
GGCAGCGGCAAGCTGGGTGTGCGCGACGTGCTGTTTGGCGGCAAGGTGTCCTACTTGGCG
CTGGGCATCTTGGTCGCTATCGCACTGGTGATCGGCGGCATCGGCGGTGTCATCGGCCGC
AAGACCGCGGAAGTAGTCGATGCGTTCACCACGTCGAAGGTGACCCTGTCGACCACTGGC
AATGCCCAGGAACCGGCCGGCCGGTTCACCAAGGTGGCGGCCGCCGTGGCCGATTCGGTG
GTGACCATTGAGTCGGTCAGCGACCAGGAGGGCATGCAAGGTTCCGGCGTCATCGTCGAT
GGCCGCGGCTACATCGTCACCAACAATCACGTGATCTCTGAGGCGGCCAACAATCCCAGC
CAGTTCAAGACGACCGTGGTGTTCAACGACGGCAAGGAGGTGCCCGCCAATCTGGTGGGT
CGTGACCCCAAGACCGACTTGGCCGTCCTCAAGGTCGACAACGTCGACAATCTGACCGTG
GCCCGGCTCGGTGATTCCAGCAAGGTACGGGTCGGTGACGAAGTCCTCGCGGTCGGCGCG
CCCCTGGGGCTGCGCAGTACGGTGACCCAGGGCATTGTCAGCGCGCTACACCGCCCCGTT
CCGTTGTCGGGCGAGGGCTCTGACACCGACACCGTCATTGACGCAATTCAGACCGACGCC
TCGATCAACCACGGTAACTCCGGCGGTCCGCTAATCGACATGGATGCCCAGGTGATTGGC
ATCAACACCGCCGGTAAGTCACTGTCGGATAGCGCCAGCGGGCTGGGCTTTGCGATCCCG
GTCAACGAGATGAAATTGGTGGCAAATTCTCTGATCAAAGACGGAAAGATCGTGCATCCG
ACGTTGGGCATCAGCACCCGGTCAGTAAGCAACGCGATCGCGTCGGGCGCGCAGGTGGCC
AATGTAAAGGCGGGAAGTCCCGCGCAGAAGGGCGGGATCTTGGAGAACGATGTGATCGTC
AAGGTCGGTAACCGCGCGGTCGCCGACTCCGACGAGTTCGTCGTCGCCGTGCGCCAGTTG
GCTATCGGCCAGGACGCTCCGATAGAGGTGGTCCGCGAGGGTCGGCATGTGACGCTGACG
GTGAAACCGGACCCCGATAGCACCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3223c	active	harsharohiratruefriend	2012-10-05
	Mutant studies MJ. White, H. He et al. PepD participates in the mycobacterial stress response mediated through MprAB and SigE. J. Bacteriol. 2010
Interaction	RegulatedBy Rv3223c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008