Rv1248c - 2-oxoglutarate dehydrogenase sucA

Expression: Most Significant Conditions for Rv1248c

Protein Domains

Gene Information
Locus	Rv1248c
Symbol	kgd
Gene Name	2-oxoglutarate dehydrogenase sucA
Location	1389357 - 1393001 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:3645 bp Protein:1215 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	476
Related Genes	Acel_0586 CE1190 cg1280 DIP1002 jk1373 MAP2536 Mkms_4047 ML1095 Mmcs_3973 MSMEG_5049 MT1286 MUL_4500 Mvan_4477 nfa46950 PPA1261 SAV2972
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1248c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1248c Transcript 1
MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAAPQAPPKPAD
TAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTATSVRAVPAKL
LIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRHYTEVDGKPTAVTPAHTN
LGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTTEDFAGVTISL
TNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHR
IIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIA
AYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAGAQYKKLRDV
LGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETF
LQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYS
QIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEG
LVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIH
IIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKK
DVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEALIGRGDISMKEAEDAL
RDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNG
FTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHS
VLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLW
EAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWA
EGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSV
LEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRE
TLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKV
HAVEQQEILDEAFG*

Genomic Sequence

>Rv1248c
ATGTACCGCAAGTTCCGCGACGACCCCTCCTCGGTCGATCCCAGCTGGCACGAGTTCCTG
GTTGACTACAGCCCCGAACCCACCTCCCAACCAGCTGCCGAACCAACCCGGGTTACCTCG
CCACTCGTTGCCGAGCGGGCCGCTGCGGCCGCCCCGCAGGCACCCCCCAAGCCGGCCGAC
ACCGCGGCCGCGGGCAACGGCGTGGTCGCCGCACTGGCCGCCAAAACTGCCGTTCCCCCG
CCAGCCGAAGGTGACGAGGTAGCGGTGCTGCGCGGCGCCGCCGCGGCCGTCGTCAAGAAC
ATGTCCGCGTCGTTGGAGGTGCCGACGGCGACCAGCGTCCGGGCGGTCCCGGCCAAGCTA
CTGATCGACAACCGGATCGTCATCAACAACCAGTTGAAGCGGACCCGCGGCGGCAAGATC
TCGTTCACGCATTTGCTGGGCTACGCCCTGGTGCAGGCGGTGAAGAAATTCCCGAACATG
AACCGGCACTACACCGAAGTCGACGGCAAGCCCACCGCGGTCACGCCGGCGCACACCAAT
CTCGGCCTGGCGATCGACCTGCAAGGCAAGGACGGGAAGCGTTCCCTGGTGGTGGCCGGC
ATCAAGCGGTGCGAGACCATGCGATTCGCGCAGTTCGTCACGGCCTACGAAGACATCGTA
CGCCGGGCCCGCGACGGCAAGCTGACCACTGAAGACTTTGCCGGCGTGACGATTTCGCTG
ACCAATCCCGGAACCATCGGCACCGTGCATTCGGTGCCGCGGCTGATGCCCGGCCAGGGC
GCCATCATCGGCGTGGGCGCCATGGAATACCCCGCCGAGTTTCAAGGCGCCAGCGAGGAA
CGCATCGCCGAGCTGGGCATCGGCAAATTGATCACTTTGACCTCCACCTACGACCACCGC
ATCATCCAGGGCGCGGAATCGGGCGACTTCCTGCGCACCATCCACGAGTTGCTGCTCTCG
GATGGCTTCTGGGACGAGGTCTTCCGCGAACTGAGCATCCCATATCTGCCGGTGCGCTGG
AGCACCGACAACCCCGACTCGATCGTCGACAAGAACGCTCGCGTCATGAACTTGATCGCG
GCCTACCGCAACCGCGGCCATCTGATGGCCGATACCGACCCGCTGCGGTTGGACAAAGCT
CGGTTCCGCAGTCACCCCGACCTCGAAGTGCTGACCCACGGCCTGACGCTGTGGGATCTC
GATCGGGTGTTCAAGGTCGACGGCTTTGCCGGTGCGCAGTACAAGAAACTGCGCGACGTG
CTGGGCTTGCTGCGCGATGCCTACTGCCGCCACATCGGCGTGGAGTACGCCCATATCCTC
GACCCCGAACAAAAGGAGTGGCTCGAACAACGGGTCGAGACCAAGCACGTCAAACCCACT
GTGGCCCAACAGAAATACATCCTCAGCAAGCTCAACGCCGCCGAGGCCTTTGAAACGTTC
CTACAGACCAAGTACGTCGGCCAGAAGCGGTTCTCGCTGGAAGGCGCCGAAAGCGTGATC
CCGATGATGGACGCGGCGATCGACCAGTGCGCTGAGCACGGCCTCGACGAGGTGGTCATC
GGGATGCCGCACCGGGGCCGGCTCAACGTGCTGGCCAACATCGTCGGCAAGCCGTACTCG
CAGATCTTCACCGAGTTCGAGGGCAACCTGAATCCGTCGCAGGCGCACGGCTCCGGTGAC
GTCAAGTACCACCTGGGCGCCACCGGGCTGTACCTGCAGATGTTCGGCGACAACGACATT
CAGGTGTCGCTGACCGCCAACCCGTCGCATCTGGAGGCCGTCGACCCGGTGCTGGAGGGA
TTGGTGCGGGCCAAGCAGGATCTGCTCGACCACGGAAGCATCGACAGCGACGGCCAACGG
GCGTTCTCGGTGGTGCCGCTGATGTTGCATGGCGATGCCGCGTTCGCCGGTCAGGGTGTG
GTCGCCGAGACGCTGAACCTGGCGAATCTGCCGGGCTACCGCGTCGGCGGCACCATCCAC
ATCATCGTCAACAACCAGATCGGCTTCACCACCGCGCCCGAGTATTCCAGGTCCAGCGAG
TACTGCACCGACGTCGCAAAGATGATCGGGGCACCGATCTTTCACGTCAACGGCGACGAC
CCGGAGGCGTGTGTCTGGGTGGCGCGGTTGGCGGTGGACTTCCGACAACGGTTCAAGAAG
GACGTCGTCATCGACATGCTGTGCTACCGCCGCCGCGGGCACAACGAGGGTGACGACCCG
TCGATGACCAACCCCTACGTGTACGACGTCGTCGACACCAAGCGCGGGGCCCGCAAAAGC
TACACCGAAGCCCTGATCGGACGTGGCGACATCTCGATGAAGGAGGCCGAGGACGCGCTG
CGCGACTACCAGGGCCAGCTGGAACGGGTGTTCAACGAAGTGCGCGAGCTGGAGAAGCAC
GGTGTGCAGCCGAGCGAGTCGGTCGAGTCCGACCAGATGATTCCCGCGGGGCTGGCCACT
GCGGTGGACAAGTCGCTGCTGGCCCGGATCGGCGATGCGTTCCTCGCCTTGCCGAACGGC
TTCACCGCGCACCCGCGAGTCCAACCGGTGCTGGAGAAGCGCCGGGAGATGGCCTATGAA
GGCAAGATCGACTGGGCCTTTGGCGAGCTGCTGGCGCTGGGCTCGCTGGTGGCCGAAGGC
AAGCTGGTGCGCTTGTCGGGGCAGGACAGCCGCCGCGGCACCTTCTCCCAGCGGCATTCG
GTTCTCATCGACCGCCACACTGGCGAGGAGTTCACACCACTGCAGCTGCTGGCGACCAAC
TCCGACGGCAGCCCGACCGGCGGAAAGTTCCTGGTCTACGACTCGCCACTGTCGGAGTAC
GCCGCCGTCGGCTTCGAGTACGGCTACACTGTGGGCAATCCGGACGCCGTGGTGCTCTGG
GAGGCGCAGTTCGGCGACTTCGTCAACGGCGCGCAGTCGATCATCGACGAGTTCATCAGC
TCCGGTGAGGCCAAGTGGGGCCAATTGTCCAACGTCGTGCTGCTGTTACCGCACGGGCAC
GAGGGGCAGGGACCCGACCACACTTCTGCCCGGATCGAACGCTTCTTGCAGTTGTGGGCG
GAAGGTTCGATGACCATCGCGATGCCGTCGACTCCGTCGAACTACTTCCACCTGCTACGC
CGGCATGCCCTGGACGGCATCCAACGCCCGCTGATCGTGTTCACGCCCAAGTCGATGTTG
CGTCACAAGGCCGCCGTCAGCGAAATCAAGGACTTCACCGAGATCAAGTTCCGCTCAGTG
CTGGAGGAACCCACCTATGAGGACGGCATCGGAGACCGCAACAAGGTCAGCCGGATCCTG
CTGACCAGTGGCAAGCTGTATTACGAGCTGGCCGCCCGCAAGGCCAAGGACAACCGCAAT
GACCTCGCGATCGTGCGGCTTGAACAGCTCGCCCCGCTGCCCAGGCGTCGACTGCGTGAA
ACGCTGGACCGCTACGAGAACGTCAAGGAGTTCTTCTGGGTCCAAGAGGAACCGGCCAAC
CAGGGTGCGTGGCCGCGATTCGGGCTCGAACTACCCGAGCTGCTGCCTGACAAGTTGGCC
GGGATCAAGCGAATCTCGCGCCGGGCGATGTCAGCCCCGTCGTCAGGCTCGTCGAAGGTG
CACGCCGTCGAACAGCAGGAGATCCTCGACGAGGCGTTCGGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - IPI	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - IPI	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - IPI	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - IPI	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - ISS	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - ISS	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - ISS	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - ISS	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - IDA	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - IDA	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	TBRXN:OXGDC 2-oxoglutarate decarboxylase - IDA	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - IDA	active	njamshidi	2012-10-05
	contrary to initial sequence based annotation, the sucA gene does not code for E1 subunit of PDH, rather it codes for akg dearboxylase see PMID: 16045627 and 16027371 J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:2.2.1.5 2-hydroxy-3-oxoadipate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Assay of unpurified protein expressed in a heterlogous host LP. de Carvalho, H. Zhao et al. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem. Biol. 2010
Term	EC:1.2.4.2 Oxoglutarate dehydrogenase (succinyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Assay of unpurified protein expressed in a heterlogous host LP. de Carvalho, H. Zhao et al. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem. Biol. 2010
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Assay of unpurified protein expressed in a heterlogous host LP. de Carvalho, H. Zhao et al. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem. Biol. 2010
Term	EC:2.2.1.5 2-hydroxy-3-oxoadipate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.2.4.2 Oxoglutarate dehydrogenase (succinyl-transferring). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:4.1.1.71 2-oxoglutarate decarboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011