Rv1317c - ada regulatory protein alkA

Expression: Most Significant Conditions for Rv1317c

Protein Domains

Gene Information
Locus	Rv1317c
Symbol	alkA
Gene Name	ada regulatory protein alkA
Location	1477628 - 1479118 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1491 bp Protein:497 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	18842
Related Genes	MAP2443 MAV_1537 Mkms_3944 Mmcs_3870 MSMEG_4925 MT1358 MUL_3945 Mvan_4322 nfa47900 SAV1934
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1317c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1317c Transcript 1
MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRFLPTAAAAQGE
GFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERL
LQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPT
ALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLR
LPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLR
AVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHT
FPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGP
WTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWT
TLEHPVNQWPPQEKIA*

Genomic Sequence

>Rv1317c
GTGCACGACGACTTCGAACGCTGCTACCGGGCGATCCAGTCCAAAGACGCCCGGTTCGAC
GGCTGGTTCGTCGTCGCGGTTTTGACCACCGGTGTCTACTGCCGGCCGAGTTGCCCCGTC
CGGCCACCGTTCGCGCGCAATGTCCGGTTCCTGCCGACTGCGGCGGCCGCTCAGGGGGAG
GGATTCCGGGCCTGCAAACGGTGCCGCCCCGACGCCTCGCCTGGGTCTCCGGAATGGAAT
GTGCGTAGTGACGTCGTGGCGCGGGCGATGCGGCTGATTGCCGACGGAACGGTGGACCGC
GACGGTGTCAGCGGCCTCGCGGCCCAGCTCGGTTACACCATTCGCCAGCTGGAGCGGCTG
TTGCAGGCCGTGGTCGGCGCCGGTCCGCTCGCGTTGGCCCGCGCCCAACGCATGCAGACC
GCCCGGGTGCTGATCGAGACCACGAACCTGCCGTTCGGCGATGTCGCATTCGCCGCCGGG
TTTTCCAGCATCCGTCAGTTCAACGACACCGTTCGCCTGGCGTGCGACGGCACACCGACG
GCATTGCGTGCGCGCGCGGCCGCCCGATTCGAGTCTGCCACCGCATCAGCGGGCACGGTG
TCGCTGCGGCTACCCGTCCGTGCACCATTCGCCTTCGAGGGTGTTTTCGGCCATCTGGCC
GCCACCGCGGTGCCGGGTTGCGAAGAGGTCCGCGATGGTGCGTACCGACGCACGCTACGG
CTCCCATGGGGCAACGGCATCGTCAGCCTGACGCCGGCACCCGATCATGTGCGCTGCCTG
CTTGTGCTCGATGATTTCCGCGACCTGATGACGGCCACTGCACGTTGCCGACGGCTGCTG
GACCTCGACGCCGATCCCGAAGCGATCGTCGAGGCGCTGGGCGCCGATCCGGATCTGCGC
GCAGTGGTGGGCAAGGCACCCGGGCAACGCATTCCCCGCACAGTCGACGAGGCAGAATTC
GCCGTGCGGGCGGTCCTCGCCCAACAGGTATCGACGAAGGCCGCAAGCACTCACGCGGGC
CGACTGGTCGCCGCCTACGGACGGCCGGTCCACGATCGCCACGGCGCTTTGACCCACACC
TTCCCGTCGATCGAGCAGCTCGCTGAGATCGATCCCGGCCATCTGGCCGTCCCCAAGGCG
CGTCAAAGGACCATAAACGCGCTCGTCGCCAGCCTTGCCGACAAAAGTCTGGTCCTGGAC
GCCGGATGTGACTGGCAACGCGCCCGCGGGCAGTTGCTAGCGCTGCCCGGAGTGGGCCCC
TGGACCGCGGAGGTCATCGCCATGCGCGGCCTCGGTGACCCGGACGCCTTTCCGGCCAGT
GATCTCGGCCTGCGGCTGGCCGCCAAAAAGCTGGGCCTGCCTGCACAACGACGAGCCCTG
ACGGTGCACAGCGCTCGCTGGCGCCCCTGGCGCTCCTATGCCACCCAGCACCTGTGGACC
ACCCTGGAACATCCGGTAAACCAATGGCCACCGCAGGAGAAGATCGCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv1316c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1316c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Other	TBPWY:Base excision repair (BER)	active	vmizrahi	2012-03-05
	Possesses methyltransferase activity. Likely positiive regulator of the adaptive response to alkylating agents. Deletion mutant lacking Rv1317c-Rv1316c alkylation damage repair and reversal operon is hypersensitive to genotoxic effects of MNNG but showed no phenotype in vivo
Symbol	adaA-alkA	active	vmizrahi	2012-03-05
	Possesses methyltransferase activity. Likely positiive regulator of the adaptive response to alkylating agents. Deletion mutant lacking Rv1317c-Rv1316c alkylation damage repair and reversal operon is hypersensitive to genotoxic effects of MNNG but showed no phenotype in vivo