Rv1416 - riboflavin synthase beta chain ribH

Expression: Most Significant Conditions for Rv1416

Protein Domains

Gene Information
Locus	Rv1416
Symbol	ribH
Gene Name	riboflavin synthase beta chain ribH
Location	1591689 - 1592153 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:465 bp Protein:155 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28172
Related Genes	Acel_1271 CE1713 cg1797 DIP1316 jk1007 MAP1141 MAV_3364 Mkms_2438 ML0560 Mmcs_2391 MSMEG_3073 MT1459 MUL_1810 Mvan_2695 nfa35990 PPA1749 SAV6905
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1416
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1416 Transcript 1
MPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPVVA
QELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQAL
DRAGLPTSAEDKGAQATVAALATALTLRELRAHS*

Genomic Sequence

>Rv1416
GTGCCGGATCTGCCGTCGCTGGATGCGTCTGGTGTGCGGCTGGCGATTGTCGCCAGCAGC
TGGCACGGAAAGATCTGCGACGCGCTGTTGGACGGCGCCCGCAAGGTGGCCGCCGGGTGT
GGCCTCGATGACCCGACTGTGGTTCGGGTGCTCGGCGCGATCGAGATTCCGGTGGTGGCG
CAGGAATTGGCCCGCAATCATGATGCCGTCGTCGCACTTGGCGTCGTGATCCGCGGTCAG
ACACCACATTTCGACTACGTGTGCGATGCGGTAACCCAGGGACTGACCCGGGTATCGCTG
GATTCCTCGACGCCGATCGCCAACGGCGTGCTGACCACCAACACCGAGGAGCAGGCGCTG
GATCGGGCGGGGCTACCGACGTCGGCCGAGGACAAGGGCGCCCAGGCGACTGTGGCAGCC
CTGGCCACCGCGTTGACCCTGCGCGAGCTGCGCGCTCACTCGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv1417	active	shahanup86	2012-10-05
	Yeast two-hybrid (Physical interaction) LI. Klepp, M. Soria et al. Identification of two proteins that interact with the Erp virulence factor from Mycobacterium tuberculosis by using the bacterial two-hybrid system. BMC Mol. Biol. 2009
Interaction	RegulatedBy Rv1963c	active	yamir.moreno	2012-10-05
	Proteomic studies. Regulated gene product concentrations measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) using proteomics techniques. MP. Santangelo, FC. Blanco et al. Study of the role of Mce3R on the transcription of mce genes of Mycobacterium tuberculosis. BMC Microbiol. 2008
Term	EC:2.5.1.9 Riboflavin synthase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,M. Cushman,T. Sambaiah,G. Jin,B. Illarionov,M. Fischer,A. Bacher Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase. J. Org. Chem. 2004