Rv1437 - phosphoglycerate kinase pgk

Expression: Most Significant Conditions for Rv1437

Protein Domains

Gene Information
Locus	Rv1437
Symbol	pgk
Gene Name	phosphoglycerate kinase pgk
Location	1614329 - 1615567 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1239 bp Protein:413 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34663
Related Genes	CE1705 cg1790 DIP1309 jk1000 MAP1165 MAV_3340 Mkms_2451 ML0571 Mmcs_2405 MSMEG_3085 MT1481 MUL_1829 Mvan_2704 nfa35880
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1437
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1437 Transcript 1
MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVV
AAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLEN
IRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGT
LVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ
GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMG
LDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGG
GDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL*

Genomic Sequence

>Rv1437
ATGAGCGTTGCAAACCTCAAGGATCTACTCGCCGAAGGTGTTTCGGGGCGTGGAGTGCTG
GTGCGCTCCGATCTCAACGTTCCGCTCGACGAGGACGGCACCATTACCGATGCGGGCCGC
ATCATCGCGTCGGCGCCGACGTTGAAGGCGTTGCTCGACGCCGACGCCAAGGTGGTGGTT
GCCGCGCACTTGGGACGTCCCAAGGACGGGCCGGACCCGACACTGTCGCTGGCGCCGGTC
GCCGTGGCGCTGGGTGAGCAACTCGGCCGGCACGTCCAGCTGGCTGGAGACGTTGTCGGC
GCCGATGCGCTGGCCCGCGCCGAGGGGCTCACCGGCGGCGACATCCTGCTGCTGGAGAAC
ATCCGCTTCGACAAACGCGAAACCAGCAAGAACGATGACGACCGGCGGGCACTGGCCAAG
CAGCTGGTCGAACTGGTCGGAACGGGAGGCGTTTTCGTCTCCGACGGCTTTGGGGTGGTG
CACCGCAAGCAAGCCTCGGTCTATGACATCGCAACCCTGTTGCCGCACTACGCCGGCACG
CTGGTCGCCGACGAGATGCGGGTACTGGAGCAGTTGACCAGCTCGACCCAGCGGCCCTAT
GCGGTAGTGCTCGGCGGATCAAAGGTGTCCGACAAGCTGGGTGTCATCGAGTCGCTGGCG
ACCAAGGCGGACAGCATTGTGATTGGCGGCGGAATGTGCTTCACATTCCTTGCTGCACAG
GGATTTTCGGTTGGCACATCGCTGCTGGAAGACGACATGATCGAAGTCTGTCGCGGGCTG
CTGGAAACCTATCACGACGTGTTGCGGCTGCCCGTGGATCTAGTGGTCACGGAGAAGTTC
GCCGCCGACTCGCCGCCCCAGACGGTCGACGTCGGCGCTGTGCCCAATGGCTTGATGGGC
CTGGATATCGGGCCGGGATCGATCAAACGGTTCAGCACGCTGCTGTCCAACGCCGGGACC
ATCTTCTGGAACGGGCCGATGGGAGTATTCGAGTTCCCGGCTTATGCGGCCGGCACCAGA
GGCGTCGCCGAGGCGATCGTCGCCGCCACCGGCAAAGGGGCGTTTAGTGTGGTCGGCGGC
GGTGACTCCGCGGCCGCAGTGCGCGCGATGAACATCCCCGAGGGCGCCTTCTCACACATA
TCCACCGGCGGCGGTGCCTCGCTGGAATACCTTGAGGGCAAGACGCTTCCCGGCATCGAG
GTACTGAGCCGTGAGCAGCCAACCGGAGGAGTTTTGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:2.7.2.3 Phosphoglycerate kinase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011