Rv1527c - polyketide synthase pks5

Expression: Most Significant Conditions for Rv1527c

Protein Domains

Gene Information
Locus	Rv1527c
Symbol	pks5
Gene Name	polyketide synthase pks5
Location	1722083 - 1728409 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:6327 bp Protein:2109 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31236
Related Genes	Mkms_3179 Mmcs_3119 MSMEG_4727 MT1580 Rv1529
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1527c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1527c Transcript 1
MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDDLVTEIPADRWDIDEY
YDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGL
TPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAIT
VDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATGRCHAFD
VSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGHTVNIATPSRSAQVAAY
REALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYGNDGPCALASVKTNFGHTQSA
AGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAV
SSYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDGALLFALSASSQDALRQTAARLA
DWVDAQGPELAPADLAYTLARRRGHRPVRTAVLAATTAELTEALREVATGEPPYPPAVGQ
DDRGPVWVFSGQGSQWAGMGADLLATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVT
GIDRVQPTLFAMQVALAATMKSYGVAPGAVIGHSLGESAAAVVAGALCLEDGVRVICRRS
ALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQSTVIGGATQTVRDLVAA
WEQRDVLAREVAVDVASHSPQVDPILDELAEALAEISPLQPEIPYYSATSFDPREEPYCD
AYYWVDNLRHTVRFAAAVQAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMR
REQPLPHGLRALAGDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHAN
TVAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAAR
AVLGEASEVRDIRFEQMLLLDDETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHV
VREADDAPDQPPQKNIAELLASHPHKVDGAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAG
DTVLAEVNLPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQGMADGGLLLPLGVRRLRSY
GSARHARYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASERARVLGERL
LSIEWHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHA
AQAARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPR
LYVLTHNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLA
ASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAAFD
RVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPGVSELKV
GDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGD
KVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIR
RDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYG
LDLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLI
LDVPHAGRSSVVLPPEQARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQP
SQKALETIELVRAIGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATL
ANITDELIERDWAPKAYGAWQLHRATADQPLDWFCSFSSAAALVGSPGQGAYAAANSWLD
TFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAIAPEEGAYAFETLLRHNRAYSGY
APVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVG
LILRRTIDTDRLLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAA
DRDAPAPA*

Genomic Sequence

>Rv1527c
GTGGGTAAGGAGAGAACAAAGACCGTGGATAGGACACGTGTTACGCCGGTAGCTGTCATT
GGTATGGGGTGCCGGCTGCCGGGGGGCATCGACTCACCCGATCGGTTGTGGGAGGCGTTG
CTGCGGGGCGACGATCTGGTCACCGAGATCCCCGCCGACCGCTGGGACATCGACGAGTAC
TACGACCCCGAACCCGGCGTGCCCGGACGCACCGACTGCAAATGGGGCGCGTACCTCGAT
AACGTCGGCGACTTTGATCCCGAGTTCTTCGGGATCGGGGAGAAAGAAGCGATAGCGATC
GATCCGCAGCACCGCTTGTTGCTGGAAACCTCCTGGGAAGCCATGGAGCACGGCGGCCTA
ACACCGAACCAGATGGCCTCGCGGACAGGGGTTTTCGTGGGGTTGGTTCATACCGACTAC
ATATTGGTACACGCCGACAACCAGACTTTCGAAGGGCCGTACGGCAACACGGGCACCAAT
GCCTGCTTCGCATCCGGGCGGGTGGCGTACGCCATGGGCTTGCAGGGTCCCGCGATCACG
GTAGATACCGCATGCTCGTCTGGCCTCACCGCTATCCACCTGGCTTGTCGTAGCCTGCAC
GACGGCGAAAGCGACATTGCGCTAGCCGGCGGTGTCTACGTGATGCTCGAACCGCGGCGG
TTCGCCTCGGGCTCGGCGTTGGGCATGTTGTCTGCGACCGGGCGCTGTCATGCGTTCGAC
GTTTCCGCGGACGGTTTCGTCTCCGGTGAGGGTTGTGTCATGTTGGCGCTCAAGCGGTTG
CCGGATGCGCTGGCCGATGGGGACCGGATCCTGGCCGTAATTCGTGGCACGGCCGCCAAC
CAAGACGGCCACACCGTCAATATCGCGACACCATCACGGTCCGCGCAGGTCGCGGCGTAT
CGGGAGGCGTTGGATGTGGCCGGTGTGGACCCGGCTACGGTGGGCATGGTCGAGGCGCAC
GGCCCGGGCACCCCGGTGGGTGACCCCATCGAATACGCCAGCCTGGCCGAGGTATACGGC
AACGACGGCCCCTGCGCGCTGGCATCGGTGAAGACCAATTTCGGCCACACCCAGTCGGCC
GCTGGAGCGCTGGGACTGATGAAGGCGGTCCTGGCCCTCCAACACGGCGTGGTCCCACAG
AATCTGCACTTCACGGCCCTGCCTGACAAGCTTGCCGCAATCGAAACCAACCTGTTTGTG
CCGCAAGAGATTACGCCGTGGCCCGGCGCCGATCAAGAAACGCCCCGGCGCGCGGCGGTG
TCGTCGTATGGCATGACGGGCACCAATGTGCACGCCATTGTCGAGCAGGCACCGGTGCCA
GCCCCCGAATCCGGTGCACCAGGCGACACCCCGGCCACACCCGGTATCGACGGCGCGCTG
CTGTTCGCGCTGTCGGCCAGCTCGCAGGACGCGCTGCGGCAGACCGCCGCGCGGCTGGCC
GATTGGGTCGACGCCCAAGGACCCGAGCTGGCGCCGGCGGATCTGGCCTACACCCTGGCC
CGCCGGCGCGGACACCGGCCGGTGCGCACCGCCGTACTGGCCGCCACCACCGCGGAGCTG
ACCGAGGCGCTGCGGGAAGTCGCCACCGGCGAACCCCCCTACCCACCCGCGGTCGGCCAA
GACGACCGCGGACCGGTCTGGGTGTTCTCCGGGCAAGGCTCGCAATGGGCGGGCATGGGC
GCCGACCTGCTGGCCACCGAACCGGTATTCGCCGCCACCATCGCCGCGATCGAACCACTG
ATCGCCGCGGAATCCGGCTTCTCGGTGACCGAAGCCATGACCGCCCCCGAGGTCGTGACC
GGCATCGACCGGGTGCAACCGACCCTGTTTGCCATGCAGGTCGCGCTGGCGGCCACAATG
AAGTCCTACGGCGTAGCGCCCGGCGCGGTCATCGGCCACTCGCTGGGCGAGTCCGCGGCC
GCGGTGGTCGCCGGCGCGCTCTGCCTCGAAGACGGAGTGCGCGTCATCTGCCGGCGGTCG
GCGCTGATGACCCGTATCGCCGGCGCCGGCGCCATGGCATCGGTGGAACTGCCTGCTCAA
CAAGTGCTTTCGGAGTTGATGGCGCGCGGCGTCAACGACGCCGTGGTCGCGGTGGTGGCC
TCCCCGCAGTCCACCGTGATCGGCGGGGCCACCCAGACGGTACGCGACCTGGTGGCCGCC
TGGGAGCAACGCGACGTGCTGGCCCGTGAGGTGGCCGTCGACGTAGCATCGCACTCCCCG
CAGGTCGACCCGATCCTCGACGAACTGGCCGAAGCGCTCGCCGAAATCAGCCCGCTGCAA
CCGGAAATCCCCTACTACTCGGCGACCTCGTTCGACCCGCGCGAGGAGCCCTACTGCGAC
GCCTACTACTGGGTGGACAACCTGCGCCACACCGTACGCTTCGCCGCGGCGGTGCAAGCC
GCCCTCGAAGACGGCTACCGGGTCTTCACCGAGCTGACCCCCCACCCCCTGCTGACCCAC
GCGGTCGACCAGACCGCCCGCAGCCTCGACATGTCCGCGGCTGCGCTGGCCGGCATGCGC
CGCGAACAACCACTGCCCCACGGGCTGCGCGCACTGGCCGGCGACCTCTACGCCGCCGGC
GCCGCCGTCGACTTCGCCGTGCTCTACCCCACCGGCCGACTGATCAACGCACCACTGCCC
ACATGGAACCACCGTCGTCTGCTGCTCGACGACACGACCCGTCGCATCGCCCACGCCAAT
ACCGTCGCCGTACACCCATTGCTGGGCTCCCACGTGCGCCTGCCCGAGGAGCCGGAACGC
CACGTCTGGCAGGGCGAGGTCGGCACCGTGACACAACCCTGGCTGGCCGATCACCAAATC
CACGGCGCGGCCGCCCTTCCGGGAGCCGCCTACTGCGAGATGGCGTTGGCCGCAGCCCGC
GCCGTCCTCGGCGAAGCCTCCGAAGTCCGCGACATCCGATTCGAGCAGATGTTGCTGCTC
GACGACGAAACCCCCATCGGCGTCACCGCCACGGTAGAAGCCCCCGGCGTTGTCCCACTC
ACAGTAGAGACCAGCCATGATGGTAGGTACACACGGCAACTCGCCGCGGTTCTGCACGTT
GTCCGGGAAGCCGACGACGCCCCGGACCAGCCACCCCAGAAAAACATCGCCGAACTGCTG
GCCAGCCATCCCCACAAGGTGGACGGCGCCGAGGTTCGGCAATGGCTGGACAAGCGTGGT
CATCGCTTAGGGCCGGCTTTTGCGGGTCTGGTTGACGCGTACATCGCCGAAGGGGCCGGC
GACACGGTGCTGGCCGAGGTCAACCTACCGGGCCCGCTTCGCTCGCAGGTCAAAGCTTAC
GGCGTGCATCCCGTGCTGCTGGATGCGTGCTTCCAGTCGGTGGCGGCTCATCCCGCCGTC
CAGGGTATGGCCGACGGTGGTTTGTTGCTGCCGTTGGGTGTGCGGCGGTTGCGGTCCTAT
GGGTCGGCCCGTCATGCCCGGTACTGCTGCACGACGGTGACCGCGTGCGGTGTGGGCGTG
GAAGCCGACCTGGACGTGTTGGACGAGCACGGCGCGGTGGTGTTGGCGGTGCGTGGGCTG
CAGTTGGGTACCGGCGCGTCGCAGGCCAGCGAACGTGCCCGGGTTTTGGGTGAGCGGCTG
CTGAGCATCGAATGGCACGAACGTGAGCTGCCCGAAAACAGCCACGCCGAACCCGGCGCC
TGGCTGCTGATCAGCACGTGTGACGCTACGGATTTGGTGGCCGCACAGTTGACCGACGCG
CTGAAGGTGCACGACGCGCAGTGCACAACGATGTCCTGGCCGCAGCGCGCCGACCACGCA
GCCCAGGCCGCGCGGCTGCGCGACCAGCTCGGCACCGGCGGGTTCACCGGCGTATTCGTG
TTGACCGCGCCGCAGACCGGCGACCCCGACGCGGAATCCCCCGTGCGCGGCGGCGAGCTT
GTCAAACATGTGGTGCGTATCGCCCGCGAGATTCCAGAGATCACGGCCCAAGAGCCGCGG
TTGTATGTGCTGACCCACAATGCTCAGGCGGTGTTGTCTGGTGACCGACCCAATCTTGAG
CAGGGTGGGATGCGGGGGTTGTTGCGGGTGATTGGTGCTGAGCATCCGCATTTGAAGGCC
AGCTATGTCGATGTGGATGAGCAGACCGGCGCGGAGTCGGTGGCGCGTCAGCTGCTGGCG
GCCAGCGGCGAGGATGAGACCGCCTGGCGCAACGACCAGTGGTACACCGCCCGGTTGTGC
CCAGCCCCGCTGCGCCCCGAGGAGCGGCAAACCACCGTCGTCGACCACGCCGAGGCCGGC
ATGCGCCTACAGATCCGTACTCCCGGTGACCTGCAAACCTTGGAGTTCGCCGCGTTCGAC
CGGGTCCCGCCGGGCCCGGGAGAGATCGAGGTCGCCGTCACCGCGTCCAGCATCAACTTC
GCCGACGTGCTGGTCACCTTCGGCCGCTACCAAACCCTCGACGGGCGACAGCCGCAGCTG
GGCACCGATTTCGCCGGGGTGGTGAGCGCGGTCGGGCCCGGGGTCAGCGAACTCAAGGTC
GGTGACCGGGTCGGCGGCATGTCACCCAACGGCTGCTGGGCCACGTTCGTCACCTGCGAC
GCCCGCCTGGCCACCAGACTGCCCGAGGGGCTGACCGACGCCCAAGCCGCGGCAGTGACC
ACCGCCAGCGCCACCGCGTGGTACGGGCTGCAGGACCTGGCGCGGATCAAGGCCGGCGAC
AAGGTGCTCATCCACTCCGCCACCGGCGGAGTGGGCCAGGCCGCAATCGCGATCGCGCGT
GCGGCCGGAGCCCAGATCTACGCCACCGCAGGCAACGAAAAGCGTCGAGACCTGCTGCGC
GACATGGGCATCGAACACGTCTATGACTCGCGCAGCGTCGAGTTCGCCGAGCAGATCCGC
CGCGACACCGCCGGCTACGGCGTGGACATCGTGCTCAACTCCGTGACCGGTGCCGCACAG
TTGGCCGGCCTCAAACTACTGGCCCTGGGCGGCCGCTTCATCGAAATCGGCAAACGCGAC
ATCTACTCCAATACCCGACTGGAACTCTTGCCATTCCGGCGCAATCTGGCGTTCTACGGT
CTAGACCTGGGGTTGATGTCGGTGAGCCATCCGGCTGCGGTCCGCGAACTGTTGAGCACG
GTGTATCGGTTGACCGTCGAGGGTGTGCTGCCGATGCCGCAGAGCACCCATTACCCGCTG
GCCGAGGCGGCCACCGCGATCCGGGTGATGGGCGCGGCCGAGCACACCGGCAAGCTCATC
CTCGACGTCCCCCACGCCGGGCGCAGCAGCGTGGTGCTTCCCCCCGAACAGGCTCGGGTT
TTCCGTTCAGACGGGTCCTACATCATCACCGGTGGCCTGGGTGGGCTGGGCTTATTCCTG
GCCGAGAAGATGGCCAACGCCGGGGCCGGCCGCATCGTGCTCAGCTCGCGCTCACAGCCC
AGCCAAAAGGCGTTGGAGACCATCGAACTCGTCCGCGCGATCGGGTCTGACGTAGTGGTG
GAGTGCGGCGATATCGCCCAGCCGGACACCGCCGACCGGTTGGTCACGGCGGCCACCGCG
ACGGGTTTGCCGCTGCGCGGCGTGCTGCACGCGGCCGCGGTGGTCGAGGACGCCACCTTG
GCCAACATCACCGACGAACTCATCGAACGCGACTGGGCGCCCAAGGCATATGGCGCCTGG
CAACTGCACCGGGCCACCGCGGACCAGCCGCTGGACTGGTTCTGCTCATTCTCCTCAGCG
GCCGCCCTGGTGGGCTCGCCGGGTCAGGGCGCCTACGCCGCGGCCAACAGCTGGCTGGAC
ACCTTCACCCACTGGCGGCGAGCCCAAGACCTACCAGCCACCTCCATCGCCTGGGGCGCC
TGGGGCCAGATCGGCCGCGCGATCGCCTTTGCCGAACAAACCGGCGACGCCATCGCCCCC
GAGGAAGGCGCCTACGCCTTCGAGACCCTGCTGCGCCACAACCGCGCCTACAGCGGCTAC
GCCCCGGTGATCGGATCACCCTGGCTGACAGCCTTCGCCCAGCACAGCCCATTCGCGGAG
AAGTTCCAATCCCTGGGGCAAAACCGTTCAGGCACAAGCAAATTCCTTGCCGAGCTGGTG
GACCTGCCCCGCGAGGAATGGCCAGACCGGCTGCGGCGGCTACTCTCCAAGCAGGTCGGC
CTAATCCTACGCCGCACCATCGACACCGACCGGCTGCTCAGCGAGTACGGCCTGGACTCA
CTGAGCAGCCAGGAACTGCGTGCGCGGGTGGAAGCCGAAACCGGGATCCGCATTTCCGCC
ACCGAAATCAACACCACCGTTCGTGGCCTGGCGGATCTGATGTGCGACAAGTTGGCGGCC
GACAGGGACGCGCCGGCACCCGCCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006