Rv1596 - nicotinate-nucleotide pyrophosphatase nadC

Expression: Most Significant Conditions for Rv1596

Protein Domains

Gene Information
Locus	Rv1596
Symbol	nadC
Gene Name	nicotinate-nucleotide pyrophosphatase nadC
Location	1797388 - 1798245 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:858 bp Protein:286 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	24695
Related Genes	Acel_0214 BL1376 CE1115 cg1215 DIP2259 jk0784 MAP1291 MAV_3189 Mkms_3126 ML1227 Mmcs_3066 MSMEG_3201 MT1632 MUL_1570 Mvan_2800 nfa18390 SAV4689
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1596
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1596 Transcript 1
MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVAL
LTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATA
TAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAG
SVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRA
PTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM*

Genomic Sequence

>Rv1596
ATGGGGTTATCCGACTGGGAGCTGGCTGCGGCTCGAGCAGCAATCGCGCGTGGGCTCGAC
GAGGACCTCCGGTACGGCCCGGATGTCACCACATTGGCGACGGTGCCTGCCAGTGCGACG
ACCACCGCATCGCTGGTGACCCGGGAGGCCGGTGTGGTTGCCGGATTGGATGTCGCGCTG
CTGACGCTGAACGAAGTCCTGGGCACCAACGGTTATCGGGTGCTCGACCGCGTCGAGGAC
GGCGCCCGGGTGCCGCCGGGAGAGGCACTTATGACGCTGGAAGCCCAAACGCGCGGATTG
TTGACCGCCGAGCGCACCATGTTGAACCTGGTCGGTCACCTGTCGGGAATCGCCACCGCG
ACGGCCGCGTGGGTCGATGCTGTGCGCGGGACCAAAGCGAAAATCCGCGATACCCGTAAG
ACGCTGCCCGGCCTGCGCGCGCTGCAAAAATACGCGGTGCGTACCGGTGGCGGCGTCAAC
CATCGGCTGGGGTTGGGTGATGCCGCGCTAATCAAGGACAACCACGTTGCCGCCGCCGGA
TCCGTGGTAGACGCGCTACGTGCGGTGCGAAATGCTGCACCCGATCTGCCGTGCGAGGTG
GAAGTGGACTCGCTTGAGCAGCTCGATGCCGTGCTGCCGGAAAAACCCGAGCTGATCCTG
CTGGACAATTTTGCGGTGTGGCAGACGCAGACCGCGGTGCAGCGTCGGGACTCGCGCGCG
CCCACCGTCATGCTGGAGTCATCCGGTGGGCTCAGCCTGCAGACGGCGGCGACCTACGCC
GAAACCGGGGTGGACTACCTGGCGGTCGGGGCGCTCACACACTCAGTGCGCGTGCTCGAC
ATCGGCTTGGATATGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv1595	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,V. Sharma,C. Grubmeyer,JC. Sacchettini Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 1998
Interaction	PhysicalInteraction Rv1594	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,V. Sharma,C. Grubmeyer,JC. Sacchettini Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 1998
Interaction	Regulatory Rv1221	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	PhysicalInteraction Rv1595	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,V. Sharma,C. Grubmeyer,JC. Sacchettini Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 1998
Interaction	PhysicalInteraction Rv1594	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,V. Sharma,C. Grubmeyer,JC. Sacchettini Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 1998
Interaction	RegulatedBy Rv2710	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, PC. Karakousis et al. Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network. J. Bacteriol. 2008
Term	EC:2.4.2.19 Nicotinate-nucleotide diphosphorylase (carboxylating). - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,V. Sharma,C. Grubmeyer,JC. Sacchettini Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 1998