Rv1633 - excinuclease ABC subunit B uvrB

Expression: Most Significant Conditions for Rv1633

Protein Domains

Gene Information
Locus	Rv1633
Symbol	uvrB
Gene Name	excinuclease ABC subunit B uvrB
Location	1837075 - 1839171 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2097 bp Protein:699 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	601
Related Genes	Acel_1106 BL0990 CE1499 cg1550 DIP1154 jk0827 MAP1335 MAV_3141 Mkms_3047 ML1387 Mmcs_3001 MSMEG_3816 MT1669 MUL_1616 Mvan_3350 nfa19020 PPA0803 SAV6273
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1633
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1633 Transcript 1
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQR
PTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD
VERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVELKVGEEVPRDGLLRLLVD
VQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQ
VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKR
NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLV
DPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTI
GRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQ
VYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLT
AQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK*

Genomic Sequence

>Rv1633
GTGCGCGCCGGCGGTCACTTCGAGGTGGTCAGTCCGCATGCTCCGGCCGGCGACCAGCCG
GCCGCAATCGACGAGCTGGAGCGGCGGATCAACGCGGGGGAGCGTGACGTGGTGTTGCTC
GGCGCCACCGGCACCGGGAAGTCGGCGACCACCGCGTGGCTGATCGAACGCCTGCAGCGG
CCCACCCTGGTGATGGCGCCCAACAAGACGTTGGCCGCCCAGCTGGCGAACGAACTGCGA
GAGATGTTGCCGCACAACGCCGTCGAGTACTTCGTCTCGTACTACGACTACTACCAGCCG
GAGGCGTATATCGCGCAGACCGACACTTATATCGAAAAGGATAGCTCCATCAACGACGAC
GTGGAGCGGCTGCGGCACTCCGCGACCTCGGCGCTGCTGTCGCGTCGTGACGTGGTGGTG
GTGGCTTCGGTGTCCTGCATCTACGGCCTGGGCACACCGCAGTCCTACCTGGACCGCTCC
GTCGAGCTGAAGGTGGGCGAGGAAGTGCCGCGCGATGGGCTGCTGCGGCTGCTGGTCGAC
GTGCAATACACCCGAAACGACATGTCCTTTACTCGCGGCTCGTTTCGGGTGCGCGGCGAC
ACCGTCGAGATCATCCCCTCCTACGAAGAGCTGGCGGTTCGCATCGAGTTCTTCGGCGAC
GAGATCGAGGCGCTGTACTATCTGCACCCGCTGACCGGCGAGGTTATCCGCCAGGTCGAC
TCGCTGCGGATCTTTCCCGCTACCCATTACGTCGCCGGTCCGGAGCGGATGGCGCATGCC
GTCTCGGCCATCGAGGAAGAACTCGCCGAGCGACTCGCCGAGCTTGAGAGCCAGGGCAAG
CTGCTGGAGGCGCAGCGGCTGCGGATGCGCACCAACTACGACATCGAAATGATGCGGCAG
GTCGGGTTCTGCTCGGGCATCGAGAACTACTCCCGCCACATCGACGGTAGGGGGCCCGGC
ACGCCGCCCGCGACCCTGCTCGACTATTTCCCCGAGGATTTCCTGCTCGTTATCGACGAG
TCACATGTCACCGTGCCGCAGATCGGCGGCATGTACGAGGGCGACATCTCCCGCAAGCGC
AACCTGGTGGAGTACGGTTTCCGGCTGCCGTCGGCGTGCGACAACCGTCCGCTGACCTGG
GAGGAGTTCGCTGACCGGATCGGGCAGACGGTGTATCTGTCTGCCACCCCGGGGCCCTAC
GAGCTCAGCCAGACCGGCGGCGAGTTCGTCGAGCAGGTGATCCGGCCGACCGGTCTGGTG
GACCCGAAAGTGGTAGTCAAGCCGACCAAAGGGCAGATCGACGACCTGATCGGCGAGATC
CGCACACGGGCAGACGCCGACCAGCGGGTGCTGGTGACGACGCTGACCAAGAAGATGGCC
GAAGACCTCACCGACTACCTGCTGGAGATGGGCATTCGGGTGCGCTACCTGCATTCGGAG
GTCGACACGTTGCGCCGGGTCGAGTTGTTGCGCCAGCTGCGTCTGGGTGACTACGACGTG
CTGGTCGGCATCAACCTGCTCCGCGAGGGCCTAGACCTGCCCGAGGTGTCGCTGGTGGCG
ATCCTCGACGCCGACAAAGAAGGATTCCTGCGGTCAAGCCGCAGCCTGATCCAGACCATC
GGACGCGCCGCTCGCAACGTGTCCGGCGAGGTGCACATGTACGCCGACAAAATCACCGAC
TCGATGAGGGAAGCCATCGACGAGACCGAACGCCGGCGGGCCAAGCAGATCGCCTACAAC
GAGGCCAACGGAATCGACCCACAGCCGCTGCGCAAAAAGATCGCCGACATCCTCGATCAG
GTCTATCGGGAGGCCGACGACACCGCCGTCGTCGAGGTCGGCGGATCCGGGCGCAACGCA
TCCCGCGGCCGGCGGGCTCAGGGTGAGCCCGGCCGGGCGGTCAGCGCCGGCGTGTTCGAG
GGCCGCGACACCTCCGCCATGCCGCGCGCTGAGCTGGCCGACCTAATCAAAGACCTCACC
GCACAGATGATGGCGGCCGCGCGCGACCTGCAGTTCGAGCTGGCGGCCCGGTTCCGCGAC
GAGATCGCCGACCTCAAGCGGGAGCTGCGGGGGATGGACGCGGCCGGCCTGAAGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activation Rv1638	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis P. Singh, KN. Patil et al. Mycobacterium tuberculosis UvrD1 and UvrA Proteins Suppress DNA Strand Exchange Promoted by Cognate and Non-cognate RecA Proteins. Biochemistry 2010
Interaction	Activation Rv1638	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis K. Kurthkoti, P. Kumar et al. Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents. Microbiology (Reading, Engl.) 2008
Interaction	Activation Rv1638	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis K. Kurthkoti, P. Kumar et al. Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents. Microbiology (Reading, Engl.) 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Mutations in uvrB result in severe sensitivity to acidified nitrite, and sensitivity to UV light but not to ROS in vitro. A uvrB mutant was attenuated in mice
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Small molecule inhibitor of UvrABC complex identified