Rv1662 - polyketide synthase pks8


Protein Domains

Gene Information
LocusRv1662
Symbolpks8
Gene Namepolyketide synthase pks8
Location1881704 - 1886512 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:4809 bp
Protein:1603 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number36280
Related GenesAcel_1266 BL1065 MAP1370 MAP1371 MAV_3107 MAV_3108 MAV_3109 MT1701 MT1702 MT1704 MUL_1655 Rv1661 Rv1664 SAV6741 SAV6754 SAV6757
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv1662
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:FASm2002 fatty acid synthase - methyl-arachidic acid - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm2002 fatty acid synthase - methyl-arachidic acid - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm2001 fatty acid synthase - tri-methyl behenic acid - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm2001 fatty acid synthase - tri-methyl behenic acid - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm1801 fatty acid synthase - dimethyl arachic acid - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm1801 fatty acid synthase - dimethyl arachic acid - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm180 fatty acid synthase - tuberculostearic acid - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermEC:2.3.1.85 Fatty-acid synthase. - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm180 fatty acid synthase - tuberculostearic acid - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermEC:2.3.1.85 Fatty-acid synthase. - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm1601 fatty acid synthase - methyl octadecanoic acid - ISSactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
TermTBRXN:FASm1601 fatty acid synthase - methyl octadecanoic acid - IDAactivenjamshidi2012-10-05
lumped rxns so no all are mono-methyl branches (some are multiple methyl group additions). pks8 and pks17 locus carries out branched methyl addition for C16-C20. PMID: 12867474
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
authors,G. Yadav,RS. Gokhale,D. Mohanty SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 2003
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
MY. Hahn, S. Raman et al. The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence. J. Bacteriol. 2005
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
authors,G. Yadav,RS. Gokhale,D. Mohanty SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 2003
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
MY. Hahn, S. Raman et al. The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence. J. Bacteriol. 2005
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
authors,G. Yadav,RS. Gokhale,D. Mohanty SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 2003
InteractionPhysicalInteraction Rv1663activevashishtrv2012-10-05
Co-expression (Functional Linkage)
MY. Hahn, S. Raman et al. The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence. J. Bacteriol. 2005
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
VS. Dubey, TD. Sirakova et al. Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J. Bacteriol. 2003
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
authors,G. Yadav,RS. Gokhale,D. Mohanty SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 2003
InteractionPhysicalInteraction Rv1663activeshahanup862012-10-05
Co-expression (Functional Linkage)
MY. Hahn, S. Raman et al. The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence. J. Bacteriol. 2005
NameMas-like protein; synthesis of mono methyl branched C16 to C20 unsaturated acids [that are minor constituents of acyltrehaloses and sulfated acyltrehaloses]activemjackson2012-10-05
Polymethyl-branched acyltrehaloses
Symbolpks8-pks17activemjackson2012-10-05
Polymethyl-branched acyltrehaloses