Rv1789 - PPE family protein


Protein Domains

Gene Information
LocusRv1789
SymbolPPE26
Gene NamePPE family protein
Location2026790 - 2027971 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1182 bp
Protein:394 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number13740
Related GenesMT1838
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionPhysicalInteraction Rv1788activegaat3s2012-10-05
Operon (Functional linkage)
authors,R. Riley,M. Pellegrini,D. Eisenberg Identifying cognate binding pairs among a large set of paralogs: the case of PE/PPE proteins of Mycobacterium tuberculosis. PLoS Comput. Biol. 2008
InteractionPhysicalInteraction Rv1788activegaat3s2012-10-05
Operon (Functional linkage)
S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
SymbolPPE25-PE19activejlew2012-03-07
Mutant is defective in ESXN and PPE41 secretion. Mutant is attenuated in macrophages and SCID mice.
authors,D. Bottai,M. Di Luca,L. Majlessi,W. Frigui,R. Simeone,F. Sayes,W. Bitter,MJ. Brennan,C. Leclerc,G. Batoni,M. Campa,R. Brosch,S. Esin Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular microbiology 2012