Rv2006 - trehalose-6-phosphate phosphatase otsB1

Expression: Most Significant Conditions for Rv2006

Protein Domains

Gene Information
Locus	Rv2006
Symbol	otsB1
Gene Name	trehalose-6-phosphate phosphatase otsB1
Location	2252002 - 2255985 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:3984 bp Protein:1328 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29900
Related Genes	Mkms_3470 Mmcs_3407 MSMEG_3954 MT2062 Mvan_4107 nfa27660
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2006
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2006 Transcript 1
MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDYLTRRPQRTGE
DHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDTVYGLQNLERQTFLQLL
NTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLAEVFAVFVDGAVTAELGL
PAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSG
ADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE
AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFELVAPDGSHHQ
NAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVHYRNVADDSVDNLIAAVRRLG
HAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPAEVGPDLRLPIYIGDDLTDEDAF
DAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDPWTLVFH
GYDPGQERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGCTVDN
ESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRSLRFRDAGGRVTTMT
QERFASMNRPNLVALQTRIESENWSGTVDFRSLVDGGVHNTLVDRYRQLSSQHLTTAEIE
VLADSVLLRTQTSQSGIAIAVAARSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQS
VTLEKVATIFTSRDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNT
EELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKV
ARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDR
AHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIG
PDEFHSGYPGNEYDGIDNNAYTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERD
QWDDVSRRMFVPFHDGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQ
ASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWV
LARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLV
LSPQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHT
IEVGCSR*

Genomic Sequence

>Rv2006
GTGCGCTGTGGCATCGTCGTCAATGTGACCGGACCGCCGCCCACCATCGACCGGCGCTAC
CACGACGCTGTCATCGTCGGCCTCGACAACGTGGTCGACAAGGCCACGCGAGTGCACGCC
GCGGCATGGACGAAGTTCTTGGATGACTACCTCACCCGACGACCCCAGCGGACCGGCGAA
GACCATTGCCCCCTCACCCACGACGACTACCGCCGCTTCTTGGCCGGCAAACCCGACGGT
GTAGCCGACTTCTTGGCCGCCCGCGGAATCAGGCTGCCGCCGGGCTCCCCGACTGATCTC
ACCGACGACACCGTGTACGGGCTGCAAAACCTCGAGCGCCAGACATTCCTGCAACTGTTG
AACACCGGTGTCCCCGAGGGCAAGTCGATTGCCTCGTTCGCACGTCGGCTGCAGGTTGCC
GGTGTCCGCGTGGCCGCCCACACCTCCCACCGTAACTACGGGCACACGCTGGATGCCACC
GGCCTGGCAGAAGTGTTTGCCGTCTTTGTCGACGGCGCCGTCACCGCCGAGCTCGGGCTA
CCGGCCGAGCCTAACCCGGCCGGCCTGATCGAGACGGCGAAGCGGCTGGGAGCAAACCCC
GGTCGCTGTGTGGTCATCGACAGCTGCCAGACCGGTCTGCGCGCCGGCCGGAACGGCGGA
TTCGCGCTGGTGATTGCCGTCGACGCGCACGGCGATGCCGAGAACCTGCTGTCCAGCGGA
GCCGACGCCGTGGTCGCAGACCTGGCCGCTGTCACGGTGGGAAGCGGCGACGCCGCCATC
TCCACGATTCCCGACGCCCTGCAGGTCTACAGCCAATTGAAAAGACTACTGACCGGCCGA
CGACCAGCGGTGTTTCTCGATTTCGACGGCACGTTATCCGATATCGTCGAGCGCCCCGAA
GCGGCAACGCTCGTCGACGGCGCAGCAGAAGCGTTGCGAGCGCTGGCGGCCCAGTGTCCG
GTGGCGGTGATAAGCGGACGCGACCTGGCCGACGTTCGCAACCGGGTCAAAGTCGACGGG
CTGTGGCTGGCCGGCAGCCACGGCTTCGAATTAGTGGCGCCAGACGGCAGCCATCACCAA
AACGCCGCCGCCACTGCAGCTATCGACGGATTGGCCGAGGCGGCAGCGCAATTGGCCGAC
GCACTCCGCGAAATCGCCGGAGCAGTAGTGGAACACAAACGCTTCGCAGTCGCAGTGCAC
TATCGCAACGTTGCCGACGACAGCGTCGACAACCTGATTGCGGCGGTGCGCCGACTCGGA
CACGCAGCAGGGCTGCGTGTCACCACCGGCCGCAAAGTCGTCGAGCTTCGCCCGGATATA
GCCTGGGACAAGGGCAAAGCACTCGATTGGATCGGTGAGCGGCTCGGCCCGGCCGAAGTC
GGCCCCGACCTACGGTTGCCGATCTACATCGGCGACGACCTTACCGACGAAGATGCCTTT
GATGCCGTGCGTTTCACCGGTGTCGGGATTGTGGTGCGCCACAACGAACACGGTGATCGA
CGGTCTGCCGCTACCTTTCGTCTCGAATGTCCTTACACCGTTTGCCAATTCCTCTCCCAG
CTGGCTTGCGATCTGCAGGAGGCAGTGCAGCACGACGATCCGTGGACTCTGGTCTTCCAC
GGCTACGACCCCGGCCAGGAGCGGCTGCGTGAAGCGCTGTGCGCGGTGGGCAACGGCTAC
CTGGGTTCGCGGGGCTGCGCACCCGAATCAGCGGAAAGCGAGGCACATTACCCGGGCACC
TATGTGGCCGGGGTGTACAACCAGCTCACTGACCACATCGAAGGGTGCACCGTTGACAAC
GAAAGCCTGGTCAACCTCCCCAACTGGTTGTCGCTGACCTTCCGTATCGACGGCGGAGCA
TGGTTCAACGTCGATACGGTCGAGTTGTTGTCCTACCGGCAGACGTTCGACCTACGCCGT
GCCACGTTGACCCGCAGCTTGCGATTCCGAGACGCCGGCGGACGAGTGACCACGATGACC
CAGGAGCGGTTCGCGTCCATGAACCGGCCCAACCTGGTCGCACTGCAAACTCGGATTGAA
TCCGAAAATTGGTCGGGCACAGTTGATTTCCGGTCACTAGTCGACGGAGGTGTGCATAAC
ACCCTGGTGGACCGCTATCGGCAACTATCCAGCCAACACCTTACCACCGCCGAGATAGAA
GTCCTGGCGGACTCGGTGTTGTTGCGCACCCAGACGTCGCAATCGGGTATCGCGATCGCG
GTCGCCGCTCGCAGTACCCTGTGGCGCGATGGCCAACGGGTCGACGCGCAATATCGGGTC
GCCAGGGACACCAACCGCGGCGGCCATGACATCCAGGTCACCCTGTCAGCGGGGCAATCG
GTCACGCTGGAAAAGGTCGCGACGATCTTCACGAGCCGGGACGCCGCGACATTGACAGCG
GCAATAAGCGCACAGCGCTGTCTAGGTGAGGCCGGTCGCTATGCCGAGCTCTGTCAACAG
CACGTCCGCGCGTGGGCACGGCTGTGGGAACGATGCGCCATCGATTTGACCGGCAACACC
GAGGAATTGCGGCTCGTGCGACTGCACCTACTGCACCTGCTACAGACCATTTCGCCGCAT
ACCGCTGAGCTCGACGCCGGGGTCCCAGCGCGCGGGCTGAACGGAGAGGCCTACCGCGGG
CATGTCTTCTGGGATGCGCTGTTCGTCGCTCCGGTGCTCAGCCTGCGGATGCCGAAGGTG
GCGCGATCGCTGCTGGACTATCGGTACCGACGACTACCCGCGGCCCGCCGAGCGGCGCAC
CGGGCGGGCCACCTTGGCGCGATGTATCCCTGGCAGTCGGGCAGCGACGGAAGCGAAGTG
AGTCAGCAGCTGCACCTCAATCCACGGTCCGGGCGGTGGACTCCCGATCCCAGTGATCGT
GCCCATCACGTCGGTCTAGCGGTTGCCTACAACGCGTGGCACTACTACCAAGTGACCGGT
GACCGCCAGTATCTCGTCGACTGCGGGGCAGAGCTGCTGGTTGAGATCGCACGCTTCTGG
GTAGGCCTGGCCAAGTTGGATGACAGTCGCGGCCGCTACCTGATCCGGGGAGTAATCGGT
CCCGACGAATTCCATTCGGGGTATCCCGGCAACGAGTACGACGGAATAGACAACAATGCG
TACACCAACGTGATGGCGGTATGGGTGATCCTGCGGGCAATGGAGGCGCTGGACCTGCTA
CCGCTGACCGATCGCCGCCATCTGATCGAAAAGCTCGGGCTGACAACGCAGGAGCGCGAC
CAATGGGACGACGTGAGCCGACGCATGTTCGTTCCATTCCACGACGGCGTGATCAGCCAG
TTCGAGGGCTATTCGGAACTGGCGGAACTGGATTGGGATCACTATCGGCACCGATACGGA
AACATCCAACGACTCGACCGGATCCTGGAAGCCGAGGGCGACAGCGTGAACAACTACCAG
GCGTCCAAGCAAGCCGACGCGCTGATGCTGCTCTACCTGCTGTCTTCCGACGAGCTGATC
GGCCTGTTGGCCCGGCTTGGCTACCGCTTCGCGCCCACACAAATCCCAGGCACCGTGGAT
TACTATCTTGCCCGCACCTCGGATGGATCTACCCTGAGCGCTGTCGTGCATGCGTGGGTT
CTCGCCCGCGCCAACCGGAGCAATGCCATGGAGTACTTCCGTCAGGTCCTGCGCTCCGAT
ATCGCCGACGTCCAGGGCGGCACAACCCAGGAAGGAATTCACCTGGCGGCCATGGCTGGC
AGCATCGACCTGCTGCAGCGTTGCTATTCCGGATTGGAACTGCGCGACGACCGGCTGGTG
TTGAGCCCGCAATGGCCGGAAGCACTTGGACCACTTGAGTTTCCGTTTGTGTACCGCCGC
CACCAGCTGAGCCTGCGAATCAGTGGCCGAAGCGCCACATTGACCGCAGAAAGTGGAGAC
GCCGAGCCAATTGAGGTCGAATGCCGTGGCCACGTGCAGCGGCTACGGTGCGGGCACACC
ATCGAAGTCGGTTGCAGCAGGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:TRE6PP trehalose-phosphatase - ISS	active	njamshidi	2012-10-05
	PMID: 10658666 KA. De Smet, A. Weston et al. Three pathways for trehalose biosynthesis in mycobacteria. Microbiology (Reading, Engl.) 2000
Term	EC:3.1.3.12 Trehalose-phosphatase. - ISS	active	njamshidi	2012-10-05
	PMID: 10658666 KA. De Smet, A. Weston et al. Three pathways for trehalose biosynthesis in mycobacteria. Microbiology (Reading, Engl.) 2000
Term	TBRXN:TRE6PP trehalose-phosphatase - IDA	active	njamshidi	2012-10-05
	PMID: 10658666 KA. De Smet, A. Weston et al. Three pathways for trehalose biosynthesis in mycobacteria. Microbiology (Reading, Engl.) 2000
Term	EC:3.1.3.12 Trehalose-phosphatase. - IDA	active	njamshidi	2012-10-05
	PMID: 10658666 KA. De Smet, A. Weston et al. Three pathways for trehalose biosynthesis in mycobacteria. Microbiology (Reading, Engl.) 2000
Interaction	RegulatedBy Rv3133c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3133c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Name	probable trehalose-6P-phosphatase, apparently inactive in MTB: INVOLVED IN TREHALOSE BIOSYNTHESIS FROM GLUCOSE 6-PHOSPHATE AND UDP-GLUCOSE	active	mjackson	2012-10-05
	Trehalose biosynthesis
Name	probable trehalose-6P-phosphatase, apparently inactive in MTB: INVOLVED IN TREHALOSE BIOSYNTHESIS FROM GLUCOSE 6-PHOSPHATE AND UDP-GLUCOSE	active	mjackson	2012-10-05
	Trehalose biosynthesis
Term	EC:3.1.3.12 Trehalose-phosphatase. - NR	active	extern:JZUCKER	2012-03-06
	Inferred by a human based on computational evidence K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005