Rv2009 - conserved hypothetical protein

Expression: Most Significant Conditions for Rv2009

Protein Domains

Gene Information
Locus	Rv2009
Symbol
Gene Name	conserved hypothetical protein
Location	2258030 - 2258272 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:243 bp Protein:81 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	9795
Related Genes
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2009
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2009 Transcript 1
MYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFD
FSNDEIESFSDTDRKLADES*

Genomic Sequence

>Rv2009
GTGTATAGTGGTGTTGTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCC
GCACAGCGGATGTACCGACTCGATTCCAAGCGAAGTGCCGTCGACCTCGCGCTGCGCCGG
CTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTTTCGAC
TTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCG
TAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Inhibits Rv2010	active	shahanup86	2012-10-05
	coexpression(Functional Linkage) authors,J. Robson,JL. McKenzie,R. Cursons,GM. Cook,VL. Arcus The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. J. Mol. Biol. 2009
Interaction	Inhibits Rv2010	active	shahanup86	2012-10-05
	coexpression(Functional Linkage) authors,HR. Ramage,LE. Connolly,JS. Cox Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 2009
Interaction	Inhibits Rv2010	active	shahanup86	2012-10-05
	coexpression(Functional Linkage) authors,J. Robson,JL. McKenzie,R. Cursons,GM. Cook,VL. Arcus The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. J. Mol. Biol. 2009
Interaction	Inhibits Rv2010	active	shahanup86	2012-10-05
	coexpression(Functional Linkage) authors,HR. Ramage,LE. Connolly,JS. Cox Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 2009
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Symbol	VapB	active	jlew	2012-03-07
	authors,BA. Ahidjo,D. Kuhnert,JL. McKenzie,EE. Machowski,BG. Gordhan,V. Arcus,GL. Abrahams,V. Mizrahi VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS ONE 2011
Symbol	VapB15	active	jlew	2012-03-07
	We report the heterologous toxicity of these TA loci in Escherichia coli and show that only a few of the M. tuberculosis-encoded toxins can inhibit E. coli growth and have a killing effect. This killing effect can be suppressed by coexpression of the cognate antitoxin. authors,A. Gupta Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 2009
Other	strand:+	active	rslayden	2012-03-05
	MTCY48.05c (54.4% identity in 68 aa overlap).
Other	stop:258272	active	rslayden	2012-03-05
	MTCY48.05c (54.4% identity in 68 aa overlap).
Other	start:2258030	active	rslayden	2012-03-05
	MTCY48.05c (54.4% identity in 68 aa overlap).
Symbol	Vap BC-15	active	rslayden	2012-03-05
	MTCY48.05c (54.4% identity in 68 aa overlap).
Other	strand:+	active	rslayden	2012-03-05
	Conserved hypothetical protein, very similar to Rv1560
Other	stop:258272	active	rslayden	2012-03-05
	Conserved hypothetical protein, very similar to Rv1560
Other	start:2258030	active	rslayden	2012-03-05
	Conserved hypothetical protein, very similar to Rv1560
Symbol	Vap BC-15	active	rslayden	2012-03-05
	Conserved hypothetical protein, very similar to Rv1560