Rv2139 - dihydroorotate dehydrogenase pyrD

Expression: Most Significant Conditions for Rv2139

Protein Domains

Gene Information
Locus	Rv2139
Symbol	pyrD
Gene Name	dihydroorotate dehydrogenase pyrD
Location	2398720 - 2399793 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1074 bp Protein:358 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33358
Related Genes	Acel_1296 BL0789 CE1643 cg1713 DIP1264 jk0365 jk0959 MAP1883 MAV_2353 Mkms_3224 Mkms_4953 ML1293 Mmcs_3162 Mmcs_4864 MSMEG_4198 MT2197 MUL_2370 Mvan_3487 Mvan_4110 nfa29160 PPA1002 SAV6868
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2139
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2139 Transcript 1
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA
PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN
NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP
NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA
WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS*

Genomic Sequence

>Rv2139
ATGTATCCCCTGGTGCGTCGGCTGTTGTTCCTGATCCCACCCGAGCACGCGCACAAGTTG
GTTTTCGCCGTGCTGCGCGGCGTGGCCGCCGTGGCGCCAGTGCGCCGGCTCTTGCGCCGA
CTGCTGGGCCCGACGGATCCGGTGCTGGCCAGCACGGTGTTCGGGGTGCGCTTCCCGGCA
CCGCTCGGGCTGGCCGCGGGGTTCGACAAGGACGGCACCGCACTATCCAGTTGGGGTGCG
ATGGGGTTCGGCTACGCCGAGATCGGCACCGTCACCGCTCATCCGCAGCCCGGCAACCCG
GCCCCCCGCCTGTTCCGGCTGGCCGACGACCGCGCCCTGCTGAACCGGATGGGGTTCAAC
AATCACGGTGCCCGGGCACTGGCGATCCGACTCGCGCGGCACCGACCCGAGATCCCGATC
GGGGTGAATATCGGCAAGACCAAGAAAACGCCGGCCGGCGACGCGGTCAACGACTACCGG
GCCAGCGCCCGGATGGTCGGCCCGCTGGCGTCGTATCTGGTGGTCAACGTCAGCTCTCCG
AACACACCGGGGTTACGCGATCTGCAGGCGGTCGAATCGCTGCGGCCCATCCTGTCTGCC
GTCCGCGCCGAGACTTCGACGCCGGTGCTGGTGAAGATCGCGCCGGACTTGTCCGATTCC
GACCTCGACGACATCGCGGACCTGGCCGTCGAGCTAGACCTGGCCGGCATCGTGGCAACC
AACACCACGGTGTCACGCGACGGCCTGACCACACCGGGGGTCGACCGGTTGGGTCCCGGC
GGCATCTCGGGGCCACCGCTGGCTCAGCGCGCGGTCCAGGTGCTGCGTCGGCTCTATGAC
CGGGTCGGTGATCGATTGGCGCTGATCAGCGTGGGCGGGATCGAGACGGCCGACGACGCG
TGGGAGCGCATCACAGCGGGCGCATCGCTGCTACAGGGCTATACCGGCTTCATCTACGGC
GGGGAACGGTGGGCCAAGGACATCCATGAAGGCATTGCCCGCAGGCTGCATGACGGCGGG
TTCGGCTCGCTGCACGAAGCGGTCGGCTCGGCAAGACGTCGGCAACCCAGCTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3575c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3575c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006