Rv2150c - cell division protein ftsZ

Expression: Most Significant Conditions for Rv2150c

Protein Domains

Gene Information
Locus	Rv2150c
Symbol	ftsZ
Gene Name	cell division protein ftsZ
Location	2408385 - 2409524 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1140 bp Protein:380 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	836
Related Genes	Acel_1012 BL0118 CE2050 cg2366 DIP1595 jk0753 MAP1894c MAV_2340 Mkms_3315 ML0917 Mmcs_3253 MSMEG_4222 MT2209 MUL_3498 Mvan_3520 nfa17690 PPA0761 SAV6124
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2150c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2150c Transcript 1
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGR
DSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARK
LGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAF
RSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEI
AINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLG
DEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGA
TLSIGGDDDDVDVPPFMRR*

Genomic Sequence

>Rv2150c
ATGACCCCCCCGCACAACTACCTGGCCGTCATCAAGGTCGTGGGTATCGGTGGTGGCGGT
GTCAACGCCGTCAACCGAATGATCGAGCAGGGCCTCAAAGGCGTGGAATTCATCGCGATC
AACACCGACGCCCAGGCGTTGTTGATGAGCGATGCCGACGTCAAACTCGACGTCGGCCGC
GACTCCACCCGCGGGCTGGGCGCCGGCGCCGATCCGGAGGTCGGCCGTAAGGCCGCCGAG
GACGCCAAGGACGAGATCGAAGAGCTGCTGCGCGGTGCCGACATGGTGTTTGTCACCGCC
GGCGAGGGGGGCGGAACCGGCACCGGGGGGGCACCCGTCGTCGCCAGCATCGCCCGCAAG
CTGGGCGCGTTGACCGTCGGTGTGGTCACCCGGCCGTTCTCGTTCGAGGGCAAGCGACGC
AGCAATCAGGCCGAAAATGGCATCGCGGCGCTGCGGGAGAGTTGCGACACCCTCATCGTG
ATTCCCAACGACCGGTTGCTGCAGATGGGAGATGCCGCGGTATCGCTGATGGATGCTTTC
CGTAGCGCCGACGAGGTGCTGCTCAACGGCGTGCAGGGCATCACCGACCTGATTACCACC
CCGGGTCTAATCAACGTCGACTTCGCCGACGTCAAGGGCATCATGTCCGGTGCCGGCACC
GCACTGATGGGCATCGGCTCGGCCCGGGGCGAAGGCCGGTCGCTCAAAGCGGCCGAGATC
GCCATCAACTCGCCGTTGCTGGAAGCCTCGATGGAGGGCGCGCAAGGCGTGCTGATGTCG
ATCGCCGGCGGCAGCGACTTGGGCTTGTTCGAGATCAACGAGGCGGCCTCGTTGGTACAA
GACGCCGCTCACCCCGATGCCAACATCATCTTCGGCACCGTCATCGACGATTCGCTCGGT
GACGAGGTGCGGGTGACCGTGATCGCGGCCGGCTTCGACGTCAGCGGTCCCGGCCGCAAG
CCGGTGATGGGCGAGACCGGCGGCGCCCACCGGATCGAGTCAGCCAAGGCAGGCAAGCTC
ACCTCGACCTTGTTCGAGCCGGTCGACGCCGTCAGCGTGCCGTTGCACACCAACGGCGCA
ACCCTGAGCATCGGCGGTGATGACGACGATGTCGACGTGCCGCCCTTCATGCGCCGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) G. Anilkumar, R. Srinivasan et al. Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2. Microbiology (Reading, Engl.) 2004
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,G. Anilkumar,R. Srinivasan,SP. Anand,P. Ajitkumar Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH. Microbiology (Reading, Engl.) 2001
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,R. Srinivasan,H. Rajeswari,P. Ajitkumar Analysis of degradation of bacterial cell division protein FtsZ by the ATP-dependent zinc-metalloprotease FtsH in vitro. Microbiol. Res. 2008
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) G. Anilkumar, MM. Chauhan et al. Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv. Gene 1998
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,C. Herman,D. Thévenet,R. D'Ari,P. Bouloc Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB. Proc. Natl. Acad. Sci. U.S.A. 1995
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,H. Zheng,L. Lu,B. Wang,S. Pu,X. Zhang,G. Zhu,W. Shi,L. Zhang,H. Wang,S. Wang,G. Zhao,Y. Zhang Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS ONE 2008
Interaction	Translation Rv3610c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) R. Srinivasan, G. Anilkumar et al. Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 2006
Interaction	Regulatory Rv3249c	active	shahanup86	2012-10-05
	ChIP (Physical interaction) RA. Slayden, DL. Knudson et al. Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis. Microbiology (Reading, Engl.) 2006
Interaction	PhysicalInteraction Rv3102c	active	ilamathi.raja	2012-10-05
	Affinity purification (Physical interaction) MA. Mir, HS. Rajeswari et al. Molecular characterisation of ABC transporter type FtsE and FtsX proteins of Mycobacterium tuberculosis. Arch. Microbiol. 2006
Interaction	PhysicalInteraction Rv3101c	active	ilamathi.raja	2012-10-05
	Affinity purification (Physical interaction) MA. Mir, HS. Rajeswari et al. Molecular characterisation of ABC transporter type FtsE and FtsX proteins of Mycobacterium tuberculosis. Arch. Microbiol. 2006
Interaction	PhysicalInteraction Rv2154c	active	harsharohiratruefriend	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv2151c	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (physical interaction) K. Sureka, T. Hossain et al. Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division. PLoS ONE 2010
Interaction	PhysicalInteraction Rv2151c	active	aparna.vchalam	2012-10-05
	Affinity purification (physical interaction) K. Sureka, T. Hossain et al. Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division. PLoS ONE 2010
Interaction	PhysicalInteraction Rv3102c	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv3101c	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv2154c	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv3102c	active	aparna.vchalam	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv3101c	active	aparna.vchalam	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	PhysicalInteraction Rv2154c	active	aparna.vchalam	2012-10-05
	Affinity purification (physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	InhibitedBy Rv2147c	active	harsharohiratruefriend	2012-10-05
	yeast-two-or-three hybrid (physical interaction) authors,MK. Buening,MR. Franklin SKF 525-A inhibition, induction, and 452-nm complex formation. Drug Metab. Dispos. null
Interaction	InhibitedBy Rv2147c	active	harsharohiratruefriend	2012-10-05
	yeast-two-or-three hybrid (physical interaction) authors,LW. Hamoen,JC. Meile,W. de Jong,P. Noirot,J. Errington SepF, a novel FtsZ-interacting protein required for a late step in cell division. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv0017c	active	priyadarshinipriyanka2001	2012-10-05
	Affinity purification (Physical interaction) P. Datta, A. Dasgupta et al. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 2002
Interaction	InhibitedBy Rv0011c	active	ashwinigbhat	2012-10-05
Interaction	InhibitedBy Rv0011c	active	priti.priety	2012-10-05
Name	Cell septation ring initiator/scaffold	active	mjackson	2012-10-05
	Cell division
Name	Cell septation ring initiator/scaffold	active	mjackson	2012-10-05
	Cell division
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	S. Roy & P. Ajitkumar Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis. J. Bacteriol. 2005
Symbol	FtsZ	active	rslayden	2012-03-05
	S. Roy & P. Ajitkumar Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis. J. Bacteriol. 2005
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	RA. Slayden, DL. Knudson et al. Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis. Microbiology (Reading, Engl.) 2006
Symbol	FtsZ	active	rslayden	2012-03-05
	RA. Slayden, DL. Knudson et al. Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis. Microbiology (Reading, Engl.) 2006
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	Y. Chen, DE. Anderson et al. Assembly dynamics of Mycobacterium tuberculosis FtsZ. J. Biol. Chem. 2007
Symbol	FtsZ	active	rslayden	2012-03-05
	Y. Chen, DE. Anderson et al. Assembly dynamics of Mycobacterium tuberculosis FtsZ. J. Biol. Chem. 2007
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	R. Jaiswal & D. Panda Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ. Protein Sci. 2008
Symbol	FtsZ	active	rslayden	2012-03-05
	R. Jaiswal & D. Panda Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ. Protein Sci. 2008
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	L. Respicio, PA. Nair et al. Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinburgh, Scotland) 2008
Symbol	FtsZ	active	rslayden	2012-03-05
	L. Respicio, PA. Nair et al. Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinburgh, Scotland) 2008
Name	Cell division protein,Z-ring complex Ib	active	rslayden	2012-03-05
	R. Jaiswal & D. Panda Differential assembly properties of Escherichia coli FtsZ and Mycobacterium tuberculosis FtsZ: an analysis using divalent calcium. J. Biochem. 2009
Symbol	FtsZ	active	rslayden	2012-03-05
	R. Jaiswal & D. Panda Differential assembly properties of Escherichia coli FtsZ and Mycobacterium tuberculosis FtsZ: an analysis using divalent calcium. J. Biochem. 2009