Rv2174 - conserved membrane protein

Expression: Most Significant Conditions for Rv2174

Protein Domains

Gene Information
Locus	Rv2174
Symbol
Gene Name	conserved membrane protein
Location	2435909 - 2437459 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1551 bp Protein:517 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28625
Related Genes	CE2068 cg2385 DIP1613 jk0734 MAP1912 MAV_2319 Mkms_3332 ML0899 Mmcs_3270 MSMEG_4241 MT2230 MUL_3517 Mvan_3537 nfa17360
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2174
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2174 Transcript 1
MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAGAVLITAGGLGAGSVRQ
HDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGRRVLAGEATEFTMRATTVI
WLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGNPNALLDDVSPIWTITTAPYG
PAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVWATPRLASHLGTHGPTALWICVL
NPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVAGIILITVAIAVKATAGIALPFLVW
VWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFAVLSAVAGVGLGWLTALAGSVKIINWL
TVPTGAANVIHALGRGLFTVDFYTLLRITRLIGIVIIAVSLPLLWWRFRRDDRAALTGVA
WSMLIVVLFVPAALPWYYSWPLAVAAPLAQARRAIAAIAGLSTWVMVIFKPDGSHGMYSW
LHFWIATACALTAWYVLYRSPDRRGVQAATPVVNTP*

Genomic Sequence

>Rv2174
ATGACTACTCCGAGCCATGCTCCAGCGGTTGATTTGGCTACAGCGAAAGATGCTGTTGTC
CAACACCTTTCGCGACTTTTCGAGTTCACTACCGGTCCGCAGGGCGGACCGGCGCGGCTG
GGCTTCGCCGGCGCGGTGCTGATCACCGCAGGCGGGCTGGGAGCCGGCAGCGTCCGCCAA
CATGACCCGCTGCTGGAGTCGATTCACATGTCCTGGCTGCGCTTCGGCCACGGACTCGTG
CTGTCGTCGATTCTGTTGTGGACAGGTGTGGGTGTGATGCTGCTTGCGTGGCTGGGTCTA
GGCCGACGGGTCCTCGCCGGCGAAGCCACCGAGTTCACCATGCGGGCAACCACCGTTATC
TGGCTGGCGCCGCTACTGCTGTCGGTGCCCGTCTTCAGCCGGGACACTTACTCGTATCTG
GCCCAAGGGGCGCTTCTGCGCGACGGTCTGGATCCTTACGCTGTTGGCCCGGTCGGTAAT
CCCAATGCGCTGCTGGACGACGTAAGCCCGATCTGGACGATCACCACCGCGCCCTACGGT
CCTGCGTTCATTCTGGTTGCGAAGTTCGTCACGGTAATCGTCGGCAACAATGTCGTCGCC
GGAACCATGCTGTTGCGTTTGTGCATGCTGCCCGGGCTGGCGTTGCTGGTCTGGGCCACT
CCACGCTTGGCCAGCCATCTCGGCACCCACGGCCCGACCGCGCTGTGGATCTGCGTGCTG
AACCCACTGGTCCTCATCCATCTGATGGGCGGGGTGCACAACGAGATGCTGATGGTGGGT
CTGATGACCGCCGGTATCGCGTTGACCGTCCAGGGCCGTAATGTCGCGGGGATCATCCTG
ATCACCGTTGCGATCGCGGTGAAGGCCACCGCCGGAATCGCGTTGCCCTTCTTGGTCTGG
GTTTGGCTGCGTCATCTGCGTGAGCGACGGGGGTACCGGCCGGTCCAGGCGTTCCTGGCA
GCCGCCGCGATATCGCTGCTGATCTTCGTCGCGGTGTTCGCGGTGCTGTCTGCGGTAGCC
GGCGTTGGCCTAGGGTGGCTGACCGCGCTGGCCGGCTCGGTGAAAATCATCAACTGGCTG
ACGGTGCCCACCGGGGCGGCCAACGTGATCCACGCGCTGGGCAGAGGGCTCTTCACGGTC
GACTTCTACACCTTGCTGCGGATCACCCGGCTGATCGGAATCGTGATCATCGCGGTGTCG
CTGCCGCTGTTGTGGTGGCGGTTCCGGCGCGACGACCGGGCCGCGCTGACCGGGGTCGCA
TGGTCGATGCTGATCGTGGTGCTGTTCGTACCCGCCGCCCTGCCGTGGTACTACTCCTGG
CCGCTGGCGGTCGCTGCCCCGTTGGCCCAGGCACGACGGGCGATCGCGGCCATCGCCGGG
CTCTCGACTTGGGTGATGGTGATCTTCAAACCCGACGGATCGCACGGGATGTATTCGTGG
CTGCACTTCTGGATCGCCACCGCCTGCGCACTGACTGCGTGGTATGTCCTGTATCGGTCA
CCGGACCGGCGCGGAGTGCAGGCTGCAACCCCGGTGGTCAATACGCCATAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Symbol	mptA	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Name	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Symbol	mptA	active	mjackson	2012-10-05
	PIM, LM and LAM biosynthesis
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation (phenotypic [mycobacterial recombinant strains]; enzymatic) AK. Mishra, LJ. Alderwick et al. Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis. Mol. Microbiol. 2007
Symbol	mptA	active	mjackson	2012-03-05
	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation (phenotypic [mycobacterial recombinant strains]; enzymatic) AK. Mishra, LJ. Alderwick et al. Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis. Mol. Microbiol. 2007
Other	TBPWY:PIM, LM and LAM biosynthesis	active	mjackson	2012-03-05
	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation (phenotypic [mycobacterial recombinant strains]; enzymatic) D. Kaur, MR. McNeil et al. New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene. J. Biol. Chem. 2007
Symbol	mptA	active	mjackson	2012-03-05
	Polyprenol phosphomannose-dependent alpha-1,6-mannosyltransferase involved in LM elongation (phenotypic [mycobacterial recombinant strains]; enzymatic) D. Kaur, MR. McNeil et al. New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene. J. Biol. Chem. 2007