Rv2225 - 3-methyl-2-oxobutanoate hydroxymethyltransferase panB

Expression: Most Significant Conditions for Rv2225

Protein Domains

Gene Information
Locus	Rv2225
Symbol	panB
Gene Name	3-methyl-2-oxobutanoate hydroxymethyltransferase panB
Location	2497742 - 2498587 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:846 bp Protein:282 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	44
Related Genes	Acel_0917 CE0116 cg0149 DIP2358 jk0674 MAP1970 MAV_2239 Mkms_3394 ML1635 Mmcs_3332 MSMEG_4298 MT2284 MUL_1330 Mvan_3602 nfa16500 RHA1_ro01169 RSP_1756 SAV5943 SCO2256
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2225
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2225 Transcript 1
MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV
GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR
FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ
TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS
GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF*

Genomic Sequence

>Rv2225
ATGTCTGAGCAGACTATCTATGGGGCCAATACCCCCGGAGGCTCCGGGCCGCGGACCAAG
ATCCGCACCCACCACCTACAGAGATGGAAGGCCGACGGCCACAAGTGGGCCATGCTGACG
GCCTACGACTATTCGACGGCCCGGATCTTCGACGAGGCCGGCATCCCGGTGCTGCTGGTC
GGTGATTCGGCGGCCAACGTCGTGTACGGCTACGACACCACCGTGCCGATCTCCATCGAC
GAGCTGATCCCGCTGGTCCGTGGCGTGGTGCGGGGTGCCCCGCACGCACTGGTCGTCGCC
GACCTGCCGTTCGGCAGCTACGAGGCGGGGCCCACCGCCGCGTTGGCCGCCGCCACCCGG
TTCCTCAAGGACGGCGGCGCACATGCGGTCAAGCTCGAGGGCGGTGAGCGGGTGGCCGAG
CAAATCGCCTGTCTGACCGCGGCGGGCATCCCGGTGATGGCACACATCGGCTTCACCCCG
CAAAGCGTCAACACCTTGGGCGGCTTCCGGGTGCAGGGCCGCGGCGACGCCGCCGAACAA
ACCATCGCCGACGCGATCGCCGTCGCCGAAGCCGGAGCGTTTGCCGTCGTGATGGAGATG
GTGCCCGCCGAGTTGGCCACCCAGATCACCGGCAAGCTTACCATTCCGACGGTCGGGATC
GGCGCTGGGCCCAACTGCGACGGCCAGGTCCTGGTATGGCAGGACATGGCCGGGTTCAGC
GGCGCCAAGACCGCCCGCTTCGTCAAACGGTATGCCGATGTCGGTGGTGAACTACGCCGT
GCTGCAATGCAATACGCCCAAGAGGTGGCCGGCGGGGTATTCCCCGCTGACGAACACAGT
TTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Term	EC:2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay M. Sugantino, R. Zheng et al. Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids. Biochemistry 2003