Rv2241 - pyruvate dehydrogenase E1 component aceE
Protein Domains

Gene Information
LocusRv2241
SymbolaceE
Gene Namepyruvate dehydrogenase E1 component aceE
Location2512539 - 2515244 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:2706 bp
Protein:902 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number28949
Related GenesCE2143 cg2466 DIP1687 jk0661 MAP1994 MAV_2196 Mkms_3424 ML1651 Mmcs_3362 MSMEG_4323 MT2301 MUL_1308 Mvan_3752 nfa16130 PPA0989 SAV5800
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
TermTBRXN:PDH pyruvate dehydrogenase - ISSactivenjamshidi2012-10-05
previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627.
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
TermTBRXN:PDH pyruvate dehydrogenase - IDAactivenjamshidi2012-10-05
previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627.
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionSignaling Rv1571activerazeeth.new2012-10-05
Co-expression
AH. Li, WL. Lam et al. Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria. J. Microbiol. Methods 2008
InteractionSignaling Rv1571activerazeeth.new2012-10-05
Co-expression
AH. Li, WL. Lam et al. Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth. Microbiology (Reading, Engl.) 2008
InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
TermEC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
TermEC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
TermEC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NRactivejjmcfadden2012-03-05
Inferred from direct assay
J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005