Rv2246 - 3-oxoacyl-[acyl-carrier protein] synthase 2 kasB
Protein Domains

Gene Information
LocusRv2246
SymbolkasB
Gene Name3-oxoacyl-[acyl-carrier protein] synthase 2 kasB
Location2519396 - 2520712 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1317 bp
Protein:439 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number36485
Related GenesMAP1998 MAP1999 MAV_2191 MAV_2192 Mkms_3428 Mkms_3429 ML1655 ML1656 Mmcs_3366 Mmcs_3367 MSMEG_4327 MSMEG_4328 MT2305 MT2306 MUL_1303 MUL_1304 Mvan_3756 Mvan_3757 nfa16170 Rv2245
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatedBy Rv3911activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Name-Ketoacyl-ACP synthaseactivemjackson2012-10-05
FAS-II
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
A. Bhatt, N. Fujiwara et al. Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 2007
TermEC:2.3.1.179 Beta-ketoacyl-acyl-carrier-protein synthase II. - NRactiveextern:JZUCKER2012-03-06
Reaction blocked in mutant
A. Bhatt, N. Fujiwara et al. Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 2007
TermEC:2.3.1.41 Beta-ketoacyl-acyl-carrier-protein synthase I. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
TermEC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005