Rv2247 - acetyl/propionyl-CoA carboxylase beta subunit accD6

Expression: Most Significant Conditions for Rv2247

Protein Domains

Gene Information
Locus	Rv2247
Symbol	accD6
Gene Name	acetyl/propionyl-CoA carboxylase beta subunit accD6
Location	2520743 - 2522164 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1422 bp Protein:474 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34730
Related Genes	Acel_0874 BL1536 CE0805 DIP0740 MAP2000 MAV_2190 Mkms_3430 ML1657 Mmcs_3368 MSMEG_4329 MT2307 MUL_1302 Mvan_3758 nfa16180 PPA2007
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2247
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2247 Transcript 1
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTD
GTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIR
ASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGG
PETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESA
EKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVT
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ
LAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL*

Genomic Sequence

>Rv2247
ATGACAATCATGGCCCCCGAGGCGGTTGGCGAGTCGCTCGACCCCCGCGATCCGCTGTTG
CGGCTGAGCAACTTCTTCGACGACGGCAGCGTGGAATTGCTGCACGAGCGTGACCGCTCC
GGAGTGCTGGCCGCGGCGGGCACCGTCAACGGTGTGCGCACCATCGCGTTCTGCACCGAC
GGCACCGTGATGGGCGGCGCCATGGGCGTCGAGGGGTGCACGCACATCGTCAACGCCTAC
GACACTGCCATCGAAGACCAGAGTCCCATCGTGGGCATCTGGCATTCGGGTGGTGCCCGG
CTGGCTGAAGGTGTGCGGGCGCTGCACGCGGTAGGCCAGGTGTTCGAAGCCATGATCCGC
GCGTCCGGCTACATCCCGCAGATCTCGGTGGTCGTCGGTTTCGCCGCCGGCGGCGCCGCC
TACGGACCGGCGTTGACCGACGTCGTCGTCATGGCGCCGGAAAGCCGGGTGTTCGTCACC
GGGCCCGACGTGGTGCGCAGCGTCACCGGCGAGGACGTCGACATGGCCTCGCTCGGTGGG
CCGGAGACCCACCACAAGAAGTCCGGGGTGTGCCACATCGTCGCCGACGACGAACTCGAT
GCCTACGACCGTGGGCGCCGGTTGGTCGGATTGTTCTGCCAGCAGGGGCATTTCGATCGC
AGCAAGGCCGAGGCCGGTGACACCGACATCCACGCGCTGCTGCCGGAATCCTCGCGACGT
GCCTACGACGTGCGTCCGATCGTGACGGCGATCCTCGATGCGGACACACCGTTCGACGAG
TTCCAGGCCAATTGGGCGCCGTCGATGGTGGTCGGGCTGGGTCGGCTGTCGGGTCGCACG
GTGGGTGTACTGGCCAACAACCCGCTACGCCTGGGCGGCTGCCTGAACTCCGAAAGCGCA
GAGAAGGCAGCGCGTTTCGTGCGGCTGTGCGACGCGTTCGGGATTCCGCTGGTGGTGGTG
GTCGATGTGCCGGGCTATCTGCCCGGTGTCGACCAGGAGTGGGGTGGCGTGGTGCGCCGT
GGCGCCAAGTTGCTGCACGCGTTCGGCGAGTGCACCGTTCCGCGGGTCACGCTGGTCACC
CGAAAGACCTACGGCGGGGCATACATTGCGATGAACTCCCGGTCGTTGAACGCGACCAAG
GTGTTCGCCTGGCCGGACGCCGAGGTCGCGGTGATGGGCGCTAAGGCGGCCGTCGGCATC
CTGCACAAGAAGAAGTTGGCCGCCGCTCCGGAGCACGAACGCGAAGCGCTGCACGACCAG
TTGGCCGCCGAGCATGAGCGCATCGCCGGCGGGGTCGACAGTGCGCTGGACATCGGTGTG
GTCGACGAGAAGATCGACCCGGCGCATACTCGCAGCAAGCTCACCGAGGCGCTGGCGCAG
GCTCCGGCACGGCGCGGCCGCCACAAGAACATCCCGCTGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Name	BIFUNCTIONAL ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT),INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS)	active	mjackson	2012-10-05
	Claisen-type condensation
Term	EC:6.4.1.3 Propionyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:6.4.1.2 Acetyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011