Rv2332 - NAD-dependent malate oxidoreductase mez

Expression: Most Significant Conditions for Rv2332

Protein Domains

Gene Information
Locus	Rv2332
Symbol	mez
Gene Name	NAD-dependent malate oxidoreductase mez
Location	2605108 - 2606754 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1647 bp Protein:549 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28061
Related Genes	MT2394 MUL_1467 PPA0888 SAV1514 SAV3870
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2332
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2332 Transcript 1
MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLA
TELGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLS
IDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVGGIQIAVGKLALYTAGGGVD
PRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE
DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTA
GMGIADQIRDAMVADGATLEQAVSQIWPIDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAV
GDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASCKHPMIFPLSNPTSRMEAIPA
DVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH
AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVD
TMWLPAYD*

Genomic Sequence

>Rv2332
ATGAGCGACGCCCGCGTGCCACGGATCCCGGCCGCGTTGTCCGCACCAAGTCTCAACCGT
GGAGTCGGCTTCACCCACGCGCAGCGGCGGCGGCTGGGGCTGACCGGCCGGCTTCCGTCG
GCCGTGCTCACGCTCGACCAACAGGCCGAACGCGTATGGCATCAGTTGCAGAGCTTGGCC
ACCGAGCTGGGCCGCAACCTGCTTCTCGAACAGCTGCACTACCGCCACGAGGTGCTGTAC
TTCAAGGTGCTGGCCGACCATTTGCCCGAACTGATGCCGGTGGTGTACACGCCCACCGTT
GGCGAGGCAATCCAACGCTTCTCCGACGAATACCGCGGGCAACGCGGACTGTTTCTGAGC
ATCGACGAACCCGACGAAATCGAGGAAGCCTTCAACACGTTGGGGCTGGGGCCCGAGGAC
GTCGACCTGATCGTGTGCACCGATGCCGAGGCGATCCTGGGTATCGGTGACTGGGGTGTG
GGTGGCATCCAGATCGCTGTGGGCAAATTGGCCCTCTACACCGCCGGCGGCGGCGTCGAT
CCGCGCCGCTGCCTCGCGGTGTCTCTGGATGTCGGCACCGACAATGAGCAGCTGCTGGCC
GATCCGTTCTATCTGGGCAATCGCCACGCCCGGCGGCGCGGTCGGGAATACGACGAGTTC
GTCAGTCGCTATATCGAAACGGCTCAACGGTTATTTCCGCGTGCCATTCTGCATTTCGAG
GACTTCGGGCCGGCGAACGCGCGGAAGATCCTAGACACATACGGCACGGATTACTGCGTG
TTCAACGATGACATGCAAGGAACCGGCGCGGTGGTCTTGGCCGCCGTATACAGCGGTCTG
AAGGTTACCGGTATCCCGCTGCGCGATCAGACAATAGTCGTCTTCGGCGCAGGCACCGCA
GGGATGGGGATCGCCGATCAGATCCGGGACGCGATGGTGGCAGACGGTGCCACGCTCGAG
CAGGCGGTGTCCCAGATCTGGCCGATCGACAGGCCGGGCCTGTTGTTCGACGACATGGAT
GACCTGCGCGACTTCCAAGTGCCGTACGCGAAAAACCGCCACCAGCTCGGTGTGGCCGTC
GGGGATCGGGTCGGGCTGAGCGACGCGATCAAGATCGCATCGCCCACTATCCTGCTCGGC
TGCTCAACGGTCTACGGAGCGTTCACCAAAGAGGTGGTCGAGGCGATGACGGCGTCCTGC
AAACACCCGATGATCTTTCCGCTGTCCAACCCGACGTCGCGCATGGAAGCCATCCCCGCC
GACGTGCTGGCGTGGTCGAATGGCAGGGCGCTGCTTGCCACCGGCAGCCCAGTCGCCCCA
GTGGAATTCGACGAAACCACCTACGTCATCGGTCAGGCCAACAACGTGTTGGCGTTTCCC
GGCATCGGACTGGGCGTCATTGTCGCTGGTGCCCGGTTGATAACCAGGCGCATGCTGCAT
GCAGCAGCGAAGGCCATTGCGCACCAGGCCAATCCGACAAATCCCGGAGACTCGCTGTTG
CCGGATGTCCAAAATCTGCGGGCCATCTCGACAACGGTCGCCGAAGCTGTCTATCGGGCC
GCCGTCCAAGACGGGGTGGCTTCCAGGACGCACGACGACGTCAGGCAGGCCATAGTCGAC
ACCATGTGGCTCCCGGCATATGACTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Term	EC:1.1.1.38 Malate dehydrogenase (oxaloacetate-decarboxylating). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.1.1.40 Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011