Rv2346c - Esat-6 like protein esxO

Expression: Most Significant Conditions for Rv2346c

Protein Domains

Gene Information
Locus	Rv2346c
Symbol	esxO
Gene Name	Esat-6 like protein esxO
Location	2625888 - 2626172 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:285 bp Protein:95 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	11442
Related Genes	MT2411 MT2420
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2346c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2346c Transcript 1
MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRN
FQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA*

Genomic Sequence

>Rv2346c
ATGACCATCAACTATCAGTTCGGTGATGTCGACGCTCATGGCGCCATGATCCGCGCTCAG
GCCGGGTTGCTGGAGGCGGAGCATCAGGCCATCGTTCGTGATGTGTTGGCCGCGGGTGAC
TTTTGGGGCGGCGCCGGTTCGGTGGCTTGCCAGGAGTTCATCACCCAGCTGGGCCGTAAC
TTCCAGGTGATCTACGAGCAGGCCAACGCCCACGGGCAGAAGGTGCAGGCTGCCGGCAAC
AACATGGCACAAACCGACAGCGCCGTCGGCTCCAGCTGGGCCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) KL. Lightbody, D. Ilghari et al. Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) Y. Feng,X. Yang,Z. Liu,Y. Liu,B. Su,Y. Ding,L. Qin,H. Yang,R. Zheng,Z. Hu Continuous treatment with recombinant Mycobacterium tuberculosis CFP-10-ESAT-6 protein activated human monocyte while deactivated LPS-stimulated macrophage. Biochem. Biophys. Res. Commun. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) KL. Lightbody, D. Ilghari et al. Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-05
	Co-Occurrence (Functional Linkage) Y. Feng,X. Yang,Z. Liu,Y. Liu,B. Su,Y. Ding,L. Qin,H. Yang,R. Zheng,Z. Hu Continuous treatment with recombinant Mycobacterium tuberculosis CFP-10-ESAT-6 protein activated human monocyte while deactivated LPS-stimulated macrophage. Biochem. Biophys. Res. Commun. 2008
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) KL. Lightbody, D. Ilghari et al. Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) Y. Feng,X. Yang,Z. Liu,Y. Liu,B. Su,Y. Ding,L. Qin,H. Yang,R. Zheng,Z. Hu Continuous treatment with recombinant Mycobacterium tuberculosis CFP-10-ESAT-6 protein activated human monocyte while deactivated LPS-stimulated macrophage. Biochem. Biophys. Res. Commun. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) KL. Lightbody, D. Ilghari et al. Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. J. Biol. Chem. 2008
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	Signaling Rv2347c	active	jhum4u2006	2012-10-03
	Co-Occurrence (Functional Linkage) Y. Feng,X. Yang,Z. Liu,Y. Liu,B. Su,Y. Ding,L. Qin,H. Yang,R. Zheng,Z. Hu Continuous treatment with recombinant Mycobacterium tuberculosis CFP-10-ESAT-6 protein activated human monocyte while deactivated LPS-stimulated macrophage. Biochem. Biophys. Res. Commun. 2008