Rv2350c - membrane-associated phospholipase C 2 plcB

Expression: Most Significant Conditions for Rv2350c

Protein Domains

Gene Information
Locus	Rv2350c
Symbol	plcB
Gene Name	membrane-associated phospholipase C 2 plcB
Location	2628781 - 2630319 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1539 bp Protein:513 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	18919
Related Genes	MT2414 MT2415 MT2416 Rv2349c Rv2351c SAV1715
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2350c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2350c Transcript 1
MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYF
GTLSDTRGFDDTTPPVVFAQSGWNPMTQAVDPAGVTLPYRFDTTRGPLVAGECVNDPDHS
WIGMHNSWNGGANDNWLPAQVPFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFC
SLLGGTTPNRLYWMSAWIDPDGTDGGPVLIEPNIQPLQHYSWRIMPENLEDAGVSWKVYQ
NKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYPLDFAADVRNNRLPKVSWVL
PGFLLSEHPAFPVNVGAVAIVDALRILLSNPAVWEKTALIVNYDENGGFFDHVVPPTPPP
GTPGEFVTVPDIDSVPGSGGIRGPIGLGFRVPCLVISPYSRGPLMVHDTFDHTSTLKLIR
ARFGVPVPNLTAWRDATVGDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQCVPNAVLGT
VTKTAIPYRVPFPQSMPTQETAPTRGIPSGLC*

Genomic Sequence

>Rv2350c
ATGACCCGCCGACAATTTTTTGCCAAAGCCGCCGCCGCTACCACCGCCGGGGCCTTCATG
TCCTTGGCTGGTCCGATTATCGAAAAAGCCTACGGAGCGGGGCCTTGCCCCGGACATTTG
ACCGACATCGAGCACATCGTGTTGTTGATGCAGGAGAATCGGTCATTCGATCACTACTTC
GGCACTCTTTCTGACACCCGCGGGTTCGATGACACCACCCCGCCGGTGGTATTCGCGCAG
TCGGGCTGGAACCCGATGACACAGGCGGTTGACCCCGCCGGCGTCACCCTTCCATATCGC
TTCGACACCACCCGGGGCCCGCTGGTCGCCGGCGAATGCGTCAACGACCCGGACCACAGC
TGGATCGGCATGCACAACTCGTGGAACGGCGGCGCCAACGACAACTGGCTGCCGGCGCAG
GTCCCGTTCAGTCCGTTGCAGGGCAACGTGCCGGTCACGATGGGTTTCTACACGCGTCGT
GACCTGCCCATTCACTACCTGCTAGCCGACACGTTCACGGTCTGCGACGGCTATTTTTGC
TCGCTGCTGGGCGGGACCACGCCCAACCGGCTCTACTGGATGAGCGCCTGGATCGACCCC
GACGGCACTGACGGCGGGCCGGTGCTGATCGAGCCCAATATCCAACCTCTGCAGCACTAC
AGCTGGCGCATCATGCCGGAGAACCTCGAAGATGCCGGGGTCAGCTGGAAGGTGTACCAA
AACAAATTGCTGGGGGCTCTCAACAACACCGTCGTCGGCTACAACGGGCTGGTCAATGAC
TTCAAGCAGGCCGCGGATCCGAGGTCGAATCTGGCCCGTTTCGGCATCTCACCGACCTAC
CCGCTGGACTTCGCCGCCGACGTCAGAAACAACCGATTACCCAAGGTCTCCTGGGTGCTG
CCCGGGTTTCTGCTGTCCGAACATCCCGCATTCCCGGTGAACGTCGGCGCCGTTGCAATT
GTCGATGCACTGCGGATCTTGCTGTCCAACCCTGCGGTGTGGGAAAAGACCGCGCTGATC
GTCAACTACGACGAGAACGGCGGGTTCTTCGACCACGTCGTGCCGCCGACACCGCCGCCG
GGGACGCCCGGCGAATTCGTCACGGTCCCCGACATCGACTCGGTGCCCGGCTCGGGTGGC
ATTCGTGGGCCGATCGGTCTGGGGTTTCGCGTCCCTTGCCTCGTCATCTCTCCCTATAGC
CGCGGCCCACTGATGGTCCACGACACCTTCGATCACACGTCAACGCTGAAGCTCATCCGC
GCGCGGTTCGGCGTCCCGGTTCCCAATCTCACCGCTTGGCGGGACGCGACGGTCGGCGAT
ATGACTTCGACGTTCAACTTCGCCGCTCCGCCGAACCCGTCGAAACCCAATCTGGACCAC
CCGCGGCTCAATGCGCTTCCGAAGTTGCCGCAGTGCGTGCCCAACGCAGTACTGGGAACG
GTGACCAAGACGGCAATTCCCTATCGGGTGCCATTCCCACAGTCGATGCCCACCCAAGAA
ACCGCACCCACTCGGGGGATTCCCAGCGGTCTCTGTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Symbol	PlcB	active	jlew	2012-03-07
	Contains a functional tat sequence. Test for functional tat sequences using a BlaC reporter. 13 identified. JA. McDonough, JR. McCann et al. Identification of functional Tat signal sequences in Mycobacterium tuberculosis proteins. J. Bacteriol. 2008