Rv2391 - ferredoxin-dependent nitrite reductase nirA

Expression: Most Significant Conditions for Rv2391

Protein Domains

Gene Information
Locus	Rv2391
Symbol	nirA
Gene Name	ferredoxin-dependent nitrite reductase nirA
Location	2684679 - 2686370 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1692 bp Protein:564 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	24876
Related Genes	Acel_2055 CE2644 cg3118 jk0243 MAP2208 MAV_1787 Mkms_3537 Mmcs_3474 MSMEG_4527 MT2461 MUL_3652 Mvan_3857 nfa14190 SAV2127
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2391
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2391 Transcript 1
MSAKENPQMTTARPAKARNEGQWALGHREPLNANEELKKAGNPLDVRERIENIYAKQGFD
SIDKTDLRGRFRWWGLYTQREQGYDGTWTGDDNIDKLEAKYFMMRVRCDGGALSAAALRT
LGQISTEFARDTADISDRQNVQYHWIEVENVPEIWRRLDDVGLQTTEACGDCPRVVLGSP
LAGESLDEVLDPTWAIEEIVRRYIGKPDFADLPRKYKTAISGLQDVAHEINDVAFIGVNH
PEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLGEVPEVWAAVTSVFRDYGYRRLRAKARLK
FLIKDWGIAKFREVLETEYLKRPLIDGPAPEPVKHPIDHVGVQRLKNGLNAVGVAPIAGR
VSGTILTAVADLMARAGSDRIRFTPYQKLVILDIPDALLDDLIAGLDALGLQSRPSHWRR
NLMACSGIEFCKLSFAETRVRAQHLVPELERRLEDINSQLDVPITVNINGCPNSCARIQI
ADIGFKGQMIDDGHGGSVEGFQVHLGGHLGLDAGFGRKLRQHKVTSDELGDYIDRVVRNF
VKHRSEGERFAQWVIRAEEDDLR*

Genomic Sequence

>Rv2391
ATGTCCGCGAAGGAGAACCCCCAAATGACCACTGCACGTCCCGCCAAGGCTCGAAATGAG
GGCCAGTGGGCGCTGGGACATCGCGAGCCACTCAACGCCAACGAAGAGCTGAAGAAGGCC
GGCAACCCGCTCGACGTGCGGGAGCGCATCGAAAACATCTACGCCAAACAGGGTTTCGAC
AGCATCGACAAGACCGACCTGCGAGGGCGCTTTCGCTGGTGGGGCCTGTACACCCAGCGT
GAGCAGGGCTACGACGGCACCTGGACCGGTGACGACAACATCGACAAGCTCGAGGCCAAA
TACTTCATGATGCGGGTGCGTTGCGACGGCGGCGCGCTCTCGGCTGCCGCGCTGCGCACG
CTGGGCCAGATCTCGACGGAGTTCGCGCGCGATACCGCCGATATCTCCGACCGGCAGAAC
GTGCAATACCACTGGATCGAAGTGGAAAACGTCCCTGAAATCTGGCGACGGTTAGACGAT
GTCGGACTGCAGACCACCGAGGCGTGCGGTGACTGCCCGCGGGTAGTGCTGGGCTCGCCG
TTGGCCGGCGAGTCGCTCGACGAAGTGCTCGACCCGACCTGGGCGATCGAGGAGATCGTG
CGTCGCTACATCGGCAAGCCCGACTTCGCCGACTTGCCGCGCAAGTACAAGACCGCCATC
TCTGGCCTGCAGGACGTCGCGCACGAGATCAACGACGTCGCCTTCATCGGCGTCAACCAT
CCCGAGCACGGACCAGGCCTGGATCTGTGGGTGGGCGGTGGACTGTCGACCAACCCGATG
CTGGCCCAGCGGGTCGGCGCCTGGGTTCCACTGGGCGAAGTGCCCGAGGTGTGGGCGGCG
GTCACCTCGGTGTTTCGCGACTACGGCTACCGGCGACTGCGCGCCAAGGCCCGGCTGAAA
TTTCTGATCAAAGACTGGGGCATAGCGAAGTTCCGCGAAGTGCTCGAAACCGAGTACCTC
AAGCGTCCGCTGATCGACGGTCCGGCCCCCGAACCGGTCAAGCATCCGATCGACCACGTC
GGGGTGCAACGACTCAAGAACGGGCTCAACGCCGTCGGAGTCGCCCCCATCGCCGGGCGG
GTATCGGGCACCATCCTCACGGCGGTCGCCGACCTGATGGCGCGGGCCGGTTCCGACCGG
ATCCGGTTCACCCCCTACCAGAAGCTGGTCATCCTCGACATTCCGGACGCCTTGCTCGAC
GACTTGATCGCCGGTCTGGACGCGCTGGGGCTGCAGTCGCGCCCGTCGCATTGGCGCCGG
AACTTGATGGCGTGCAGCGGGATTGAGTTCTGCAAGTTGTCATTCGCCGAAACCCGGGTT
CGAGCACAGCATTTGGTGCCCGAGCTGGAACGCCGGCTTGAGGACATCAACTCGCAGCTC
GACGTACCGATCACCGTCAACATCAACGGCTGCCCGAACTCATGTGCGCGAATTCAAATC
GCCGACATCGGATTCAAGGGACAGATGATCGACGACGGACACGGCGGCTCCGTCGAAGGC
TTCCAGGTGCATCTGGGCGGACACCTCGGCCTGGATGCCGGATTCGGCCGCAAACTGCGC
CAGCACAAGGTCACCAGTGACGAACTCGGCGACTACATCGACCGGGTGGTGCGCAACTTC
GTCAAACACCGCAGCGAAGGTGAACGCTTCGCGCAGTGGGTCATCCGGGCCGAGGAGGAC
GACCTGCGATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Term	EC:1.7.7.1 Ferredoxin--nitrite reductase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay R. Schnell, T. Sandalova et al. Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site. J. Biol. Chem. 2005