Rv2429 - alkyl hydroperoxide reductase D protein ahpD
Protein Domains

Gene Information
LocusRv2429
SymbolahpD
Gene Namealkyl hydroperoxide reductase D protein ahpD
Location2726806 - 2727339 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:534 bp
Protein:178 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number1996
Related GenesDIP1419 MAP1588c MAV_2840 MSMEG_4890 MT2504 MUL_3000 nfa37900 SAV3233
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv2429
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionActivation Rv2428activesinghpankaj21162012-10-05
Structural analysis
BG. Guimarães, H. Souchon et al. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem. 2005
InteractionActivation Rv2428activesinghpankaj21162012-10-05
Structural analysis
BG. Guimarães, H. Souchon et al. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem. 2005
InteractionRegulatory Rv0616cactiveakankshajain.212012-10-05
Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
InteractionPhysicalInteraction Rv0462activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv0462activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionPhysicalInteraction Rv0462activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv0462activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionRegulatedBy Rv0981activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
InteractionRegulatedBy Rv2711activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
CommentComment: Rv2429, (MTCY428.17c), len: 177 aa. ahpD, alkyl hydroperoxide reductase, similar to other alkyl hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from Streptomyces coelicolor (178 aa), FASTA scores: opt: 611, E(): 1.4e-33, (57.4% identity in 169 aa overlap); Q50441|AHPD_MYCSM AHPD PROTEIN (FRAGMENT) from Mycobacterium smegmatis (52 aa), FASTA score: opt:196.

Adapted from Tuberculist.		activeextern:WYMORE2011-12-12
TB Drug Resistance TermFLQactiveextern:WYMORE2011-12-12
TB Drug Resistance TermETHactiveextern:WYMORE2011-12-12
TB Pathway TermArsenate Detoxificationactiveextern:WYMORE2011-12-12
Gene Ontology Termlipoteichoic acid receptor activity - ISAactiveextern:WYMORE2011-12-12
Test
Gene Ontology Termcellular_component - IC
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
GM. Rodriguez, MI. Voskuil et al.
Infect. Immun. 2002		activeextern:WYMORE2011-12-12
Gene Ontology TermMAP kinase kinase kinase activity - IC
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
GM. Rodriguez, MI. Voskuil et al.
Infect. Immun. 2002		activeextern:WYMORE2011-12-12
SynonymsSynonyms: Test_synonymactiveextern:WYMORE2011-12-12
None
SynonymsSynonyms: TBDB's favoriteactiveextern:WYMORE2011-12-12