Rv2430c - PPE family protein

Expression: Most Significant Conditions for Rv2430c

Protein Domains

Gene Information
Locus	Rv2430c
Symbol	PPE41
Gene Name	PPE family protein
Location	2727336 - 2727920 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:585 bp Protein:195 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	9119
Related Genes	MT2505
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2430c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2430c Transcript 1
MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPV
VMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILI
DNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLV
APVSPSTASSRTDT*

Genomic Sequence

>Rv2430c
ATGCATTTCGAAGCGTACCCACCGGAGGTCAACTCCGCCAACATATATGCCGGCCCCGGT
CCTGACTCGATGTTGGCTGCCGCCAGGGCGTGGAGGTCGTTGGATGTGGAAATGACGGCC
GTGCAGAGGTCGTTCAACCGAACGCTGCTGTCTCTGATGGACGCCTGGGCGGGTCCAGTG
GTGATGCAGTTGATGGAGGCAGCCAAGCCGTTTGTCAGGTGGCTGACCGACCTCTGTGTG
CAGCTGTCTGAGGTCGAGAGGCAGATCCACGAGATCGTGCGGGCCTATGAATGGGCACAT
CACGATATGGTGCCCCTGGCGCAGATCTACAACAACCGTGCTGAGAGGCAGATTCTGATC
GACAACAACGCGCTTGGGCAATTCACTGCGCAGATCGCCGACCTCGACCAAGAATATGAC
GACTTCTGGGACGAGGACGGAGAGGTGATGAGGGACTACAGGCTTCGGGTGTCGGATGCG
TTGTCGAAGTTGACTCCGTGGAAGGCGCCGCCGCCGATCGCCCACAGTACCGTGTTGGTC
GCACCGGTGTCACCCAGCACGGCGTCATCGCGTACAGACACTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Structural Analysis authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv2431c	active	singhpankaj2116	2012-10-05
	Spectrophotometric authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv1784	active	aparna.vchalam	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1784	active	aparna.vchalam	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1784	active	aparna.vchalam	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv1784	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1784	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1784	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv1783	active	aparna.vchalam	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1783	active	aparna.vchalam	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1783	active	aparna.vchalam	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv1783	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1783	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1783	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv1782	active	aparna.vchalam	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1782	active	aparna.vchalam	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1782	active	aparna.vchalam	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	PhysicalInteraction Rv1782	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry authors,AM. Abdallah,ND. Savage,M. van Zon,L. Wilson,CM. Vandenbroucke-Grauls,NN. van der Wel,TH. Ottenhoff,W. Bitter The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J. Immunol. 2008
Interaction	PhysicalInteraction Rv1782	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry S. Tundup, N. Pathak et al. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 2008
Interaction	PhysicalInteraction Rv1782	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometry AM. Abdallah, T. Verboom et al. A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 2006
Interaction	Regulatory Rv0616c	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	RegulatedBy Rv0491	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Symbol	PE25	active	jlew	2012-03-07
	PPE25 and PPE41 interact. Using an in vivo pull-down assay, for the first time we have confirmed the presence of three pairs of PE/PPE-related novel protein interactions in this pathogen. J. Zeng, L. Zhang et al. Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expr. Purif. 2010