Rv2438c - glutamine-dependent NAD(+) synthetase nadE

Expression: Most Significant Conditions for Rv2438c

Protein Domains

Gene Information
Locus	Rv2438c
Symbol	nadE
Gene Name	glutamine-dependent NAD(+) synthetase nadE
Location	2734792 - 2736831 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2040 bp Protein:680 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33396
Related Genes	MAP2258c MAV_1737 Mkms_3616 ML1463 Mmcs_3543 MSMEG_4617 MT2513 MUL_3705 Mvan_3940
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2438c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2438c Transcript 1
MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVFPELTLSGYSI
EDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRHRHRIYNTAVVIHRGAVLGVVP
KSYLPTYREFYERRQMAPGDGERGTIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMF
VPMPPSAEAALAGATVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTT
DLAWDGQTMIWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRRHHRELT
ESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAYNIQVSGLEQRLRALDY
PKVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFALPGFATGEHTKNNAIKLARALG
VTFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGT
GDLSELALGWSTYGVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDT
EITPELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWNDAERGNW
PPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAP
SDMSARIWLDQIDREVPKG*

Genomic Sequence

>Rv2438c
ATGAACTTTTACTCCGCCTACCAGCACGGGTTCGTGCGCGTTGCCGCCTGCACTCACCAC
ACCACCATCGGTGACCCGGCGGCCAACGCCGCGTCGGTATTGGACATGGCCCGTGCGTGC
CACGACGATGGCGCAGCGTTGGCGGTCTTTCCTGAGCTGACGCTGTCGGGCTACTCCATC
GAGGACGTACTACTGCAGGACTCTCTGCTCGATGCCGTCGAGGACGCGCTGCTCGACCTG
GTGACCGAATCCGCCGACCTGTTACCTGTACTGGTGGTCGGGGCTCCGCTGCGGCATCGA
CACCGCATCTACAACACCGCGGTCGTCATTCACCGCGGCGCCGTGCTCGGCGTGGTGCCC
AAGTCGTATCTACCCACCTATCGCGAGTTCTACGAGCGGCGCCAGATGGCGCCCGGAGAC
GGGGAGCGGGGCACGATCCGCATCGGTGGCGCCGACGTGGCCTTCGGCACGGACCTGTTG
TTCGCCGCGTCAGATCTACCCGGCTTTGTGTTGCATGTGGAGATCTGCGAGGACATGTTT
GTGCCGATGCCGCCCAGCGCCGAGGCGGCCCTGGCGGGCGCGACGGTGCTGGCGAATCTG
TCCGGCAGCCCGATCACCATCGGCCGTGCCGAGGACCGCCGGCTGCTTGCGCGCTCGGCG
TCGGCGCGGTGTCTGGCTGCCTATGTCTATGCCGCCGCGGGGGAGGGGGAGTCAACGACG
GACCTGGCCTGGGACGGTCAGACGATGATCTGGGAGAATGGCGCACTGCTCGCGGAGTCC
GAACGTTTCCCCAAAGGAGTGCGCCGCAGTGTCGCCGACGTTGACACCGAGTTGCTTCGG
TCGGAGCGGCTGCGGATGGGCACGTTCGACGACAACCGGCGTCACCACCGGGAGTTAACG
GAATCGTTCCGGCGCATCGACTTCGCACTCGACCCACCGGCAGGCGACATCGGACTGCTG
CGCGAGGTCGAGCGGTTCCCGTTCGTTCCGGCCGATCCGCAACGATTGCAACAGGATTGC
TACGAGGCCTACAACATCCAGGTGTCTGGACTCGAGCAACGGTTGCGGGCGCTGGACTAT
CCGAAGGTCGTTATCGGTGTGTCCGGGGGATTGGACTCGACGCACGCGCTGATCGTCGCG
ACCCATGCCATGGACCGCGAGGGCCGGCCGCGCAGCGACATTCTGGCGTTTGCGTTGCCC
GGATTCGCCACCGGGGAGCACACTAAGAACAACGCGATCAAGCTGGCACGTGCGCTGGGG
GTTACCTTCTCCGAAATCGATATCGGCGACACCGCTCGGTTGATGCTGCACACAATCGGC
CATCCGTATTCGGTTGGCGAAAAAGTGTACGACGTCACCTTCGAGAACGTCCAGGCCGGG
TTGCGCACCGACTATCTTTTCCGTATCGCCAACCAGCGCGGGGGAATCGTACTGGGCACC
GGGGACCTGTCGGAGCTGGCACTGGGTTGGTCGACATACGGTGTCGGCGACCAGATGTCG
CACTACAACGTCAACGCCGGTGTGCCCAAGACGCTGATCCAGCACCTGATCCGGTGGGTC
ATTTCGGCGGGTGAGTTCGGTGAGAAGGTGGGTGAGGTATTGCAGTCGGTGCTCGACACC
GAGATCACCCCCGAACTCATTCCGACCGGCGAGGAGGAGCTGCAGAGCAGCGAGGCCAAG
GTCGGACCTTTCGCCCTACAGGACTTTTCGCTTTTTCAGGTACTGCGCTACGGATTTCGC
CCGTCGAAGATTGCGTTTTTGGCCTGGCATGCGTGGAACGATGCGGAGCGGGGCAACTGG
CCGCCCGGCTTCCCAAAGAGCGAACGCCCGTCCTATTCATTGGCCGAAATCCGGCATTGG
CTGCAGATTTTCGTCCAGCGGTTTTATTCGTTTAGCCAGTTCAAGCGTTCGGCATTGCCC
AACGGCCCCAAGGTGTCCCACGGGGGCGCGTTGTCGCCGCGTGGGGATTGGCGGGCCCCG
TCGGATATGTCAGCGCGAATCTGGCTCGATCAGATCGACCGTGAGGTGCCCAAGGGCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	EC:6.3.1.5 NAD(+) synthase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay M. Bellinzoni, E. De Rossi et al. Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase. Protein Expr. Purif. 2002
Term	EC:6.3.5.1 NAD(+) synthase (glutamine-hydrolyzing). - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay M. Bellinzoni, E. De Rossi et al. Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase. Protein Expr. Purif. 2002