Rv2454c - oxidoreductase beta subunit

Expression: Most Significant Conditions for Rv2454c

Protein Domains

Gene Information
Locus	Rv2454c
Symbol
Gene Name	oxidoreductase beta subunit
Location	2753625 - 2754746 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1122 bp Protein:374 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	3022
Related Genes	Acel_0283 MAP2276c MAV_1718 Mkms_3639 Mmcs_3566 MSMEG_4645 MT2529 MUL_3725 Mvan_3964 nfa36610 PPA1905 SAV4876
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2454c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2454c Transcript 1
MTRSGDEAQLMTGVTGDLAGTELGLTPSLTKNAGVPTTDQPQKGKDFTSDQEVRWCPGCG
DYVILNTIRNFLPELGLRRENIVFISGIGCSSRFPYYLETYGFHSIHGRAPAIATGLALA
REDLSVWVVTGDGDALSIGGNHLIHALRRNINVTILLFNNRIYGLTKGQYSPTSEVGKVT
KSTPMGSLDHPFNPVSLALGAEATFVGRALDSDRNGLTEVLRAAAQHRGAALVEILQDCP
IFNDGSFDALRKEGAEERVIKVRHGEPIVFGANGEYCVVKSGFGLEVAKTADVAIDEIIV
HDAQVDDPAYAFALSRLSDQNLDHTVLGIFRHISRPTYDDAARSQVVAARNAAPSGTAAL
QSLLHGRDTWTVD*

Genomic Sequence

>Rv2454c
ATGACCCGCTCCGGCGATGAAGCACAGCTCATGACCGGCGTGACCGGTGATTTGGCGGGC
ACCGAGCTCGGCCTGACTCCGAGCTTGACCAAGAACGCTGGGGTGCCCACCACGGATCAG
CCGCAGAAGGGCAAGGATTTCACCAGTGACCAGGAGGTGCGCTGGTGCCCGGGCTGCGGC
GACTACGTCATCCTCAACACCATCCGAAACTTCCTGCCCGAACTGGGGCTGCGGCGTGAG
AACATCGTGTTCATCAGCGGTATCGGATGCTCCAGCCGGTTCCCCTATTACCTGGAAACC
TACGGCTTTCATTCGATTCACGGCCGCGCGCCCGCGATAGCGACCGGTCTGGCGCTGGCT
CGCGAGGATCTGTCGGTATGGGTGGTCACCGGCGACGGTGACGCCTTGTCGATCGGCGGT
AACCACCTGATCCACGCGCTGCGCCGCAACATCAACGTGACGATTCTGCTGTTCAACAAC
CGGATCTATGGGCTGACCAAAGGACAGTATTCGCCGACATCGGAGGTCGGCAAGGTCACC
AAGTCGACACCGATGGGCTCGCTGGATCACCCGTTCAATCCGGTGTCGTTGGCGCTGGGG
GCAGAGGCGACGTTCGTTGGCCGCGCGCTGGACTCAGACCGTAACGGGCTGACCGAAGTG
CTGCGTGCCGCGGCCCAGCATCGCGGTGCTGCCCTGGTCGAAATCCTGCAGGACTGCCCG
ATCTTCAACGACGGCTCGTTCGATGCGCTGCGCAAGGAGGGCGCCGAGGAGCGGGTCATC
AAGGTCCGCCACGGCGAGCCGATCGTCTTCGGGGCCAACGGCGAATACTGCGTGGTCAAG
TCCGGATTCGGCCTCGAAGTGGCCAAGACGGCCGATGTGGCCATCGACGAGATCATTGTG
CACGATGCGCAGGTCGACGACCCGGCCTACGCCTTCGCGCTGTCCCGGCTGTCCGATCAG
AACCTGGACCACACCGTGCTGGGAATCTTTCGGCACATCAGCCGGCCAACCTACGATGAT
GCGGCCCGCTCGCAGGTAGTCGCGGCCCGAAACGCCGCCCCGTCCGGCACCGCTGCACTG
CAGTCACTGTTGCACGGGCGCGACACTTGGACCGTCGACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2455c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,AK. Ojha,AD. Baughn,D. Sambandan,T. Hsu,X. Trivelli,Y. Guerardel,A. Alahari,L. Kremer,WR. Jacobs,GF. Hatfull Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv2455c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,HI. Boshoff,CE. Barry Tuberculosis - metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 2005
Interaction	PhysicalInteraction Rv2455c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,AK. Ojha,AD. Baughn,D. Sambandan,T. Hsu,X. Trivelli,Y. Guerardel,A. Alahari,L. Kremer,WR. Jacobs,GF. Hatfull Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv2455c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,HI. Boshoff,CE. Barry Tuberculosis - metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 2005
Term	EC:1.2.7.3 2-oxoglutarate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype AD. Baughn, SJ. Garforth et al. An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. PLoS Pathog. 2009
Term	EC:1.2.7.3 2-oxoglutarate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011