Rv2455c - oxidoreductase alpha subunit

Expression: Most Significant Conditions for Rv2455c

Protein Domains

Gene Information
Locus	Rv2455c
Symbol
Gene Name	oxidoreductase alpha subunit
Location	2754743 - 2756704 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1962 bp Protein:654 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	3023
Related Genes	Acel_0284 MAP2277c MAV_1717 Mkms_3640 Mmcs_3567 MSMEG_4646 MT2530 MUL_3726 Mvan_3965 nfa36600 PPA1904 SAV4877
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2455c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2455c Transcript 1
MDPNGSGAGPESHDAAFHAAPDRQRLENVVIRFAGDSGDGMQLTGDRFTSEAALFGNDLA
TQPNYPAEIRAPAGTLPGVSSFQIQIADYDILTAGDRPDVLVAMNPAALKANIGDLPLGG
MVIVNSDEFTKRNLTKVGYVTNPLESGELSDYVVHTVAMTTLTLGAVEAIGASKKDGQRA
KNMFALGLLSWMYGRELEHSEAFIREKFARKPEIAEANVLALKAGWNYGETTEAFGTTYE
IPPATLPPGEYRQISGNTALAYGIVVAGQLAGLPVVLGSYPITPASDILHELSKHKNFNV
VTFQAEDEIGGICAALGAAYGGALGVTSTSGPGISLKSEALGLGVMTELPLLVIDVQRGG
PSTGLPTKTEQADLLQALYGRNGESPVAVLAPRSPADCFETALEAVRIAVSYHTPVILLS
DGAIANGSEPWRIPDVNALPPIKHTFAKPGEPFQPYARDRETLARQFAIPGTPGLEHRIG
GLEAANGSGDISYEPTNHDLMVRLRQAKIDGIHVPDLEVDDPTGDAELLLIGWGSSYGPI
GEACRRARRRGTKVAHAHLRYLNPFPANLGEVLRRYPKVVAPELNLGQLAQVLRGKYLVD
VQSVTKVKGVSFLADEIGRFIRAALAGRLAELEQDKTLVARLSAATAGAGANG*

Genomic Sequence

>Rv2455c
GTGGATCCGAACGGCAGCGGGGCCGGGCCAGAGTCTCATGACGCGGCATTTCATGCCGCG
CCTGATCGGCAACGCTTGGAAAATGTGGTGATCCGGTTCGCTGGAGACTCCGGCGACGGC
ATGCAGCTAACCGGCGACCGATTCACCTCGGAGGCAGCGCTTTTCGGCAACGATCTGGCG
ACCCAGCCGAACTACCCCGCAGAGATCCGGGCACCGGCGGGCACGTTGCCCGGAGTGTCG
TCTTTTCAGATTCAGATAGCCGATTACGACATCCTGACCGCCGGTGACCGTCCCGACGTG
CTCGTCGCCATGAACCCGGCAGCGTTGAAGGCCAATATCGGCGACCTACCGCTTGGCGGA
ATGGTGATCGTGAACTCTGACGAGTTCACCAAGCGCAACCTGACGAAAGTGGGCTACGTG
ACAAACCCGCTGGAGTCCGGCGAGCTGTCCGACTATGTGGTGCACACCGTCGCCATGACC
ACACTGACCCTGGGTGCCGTCGAGGCGATCGGCGCGTCCAAGAAGGATGGCCAGCGCGCC
AAAAATATGTTTGCGCTGGGTCTGCTGTCGTGGATGTACGGGCGCGAGCTCGAGCACAGC
GAGGCCTTCATCAGGGAGAAGTTCGCCCGCAAGCCCGAAATCGCCGAGGCCAACGTGTTG
GCCCTCAAGGCCGGCTGGAACTACGGCGAAACCACCGAGGCCTTCGGCACGACCTATGAG
ATACCGCCCGCGACTTTGCCGCCCGGCGAGTACCGGCAGATCTCGGGCAATACCGCGCTG
GCCTACGGGATCGTGGTGGCCGGTCAGCTCGCCGGCCTTCCGGTCGTGCTCGGCAGTTAT
CCGATTACTCCGGCGTCGGACATCCTGCACGAACTGTCCAAGCACAAGAACTTCAATGTC
GTCACCTTCCAGGCCGAAGACGAGATCGGCGGCATCTGCGCTGCGCTGGGTGCCGCCTAC
GGTGGTGCGTTGGGAGTCACCAGCACATCGGGACCGGGAATTTCGCTGAAGTCCGAAGCG
CTGGGACTGGGTGTGATGACCGAACTGCCGTTGCTGGTCATAGACGTGCAGCGGGGCGGG
CCGTCGACCGGTCTACCCACCAAGACCGAGCAGGCCGACTTGCTGCAGGCGCTCTACGGC
CGCAATGGCGAGTCACCGGTGGCGGTGCTGGCGCCGCGCTCTCCTGCCGACTGCTTTGAA
ACCGCCCTTGAGGCGGTGCGCATCGCGGTGTCCTACCACACCCCGGTGATCTTGTTGTCC
GACGGCGCCATCGCCAACGGCTCGGAGCCATGGCGAATCCCGGATGTCAATGCGCTACCG
CCCATTAAGCACACCTTCGCCAAACCCGGCGAGCCCTTCCAGCCTTATGCCCGTGACCGG
GAAACCCTTGCCCGCCAGTTCGCCATTCCGGGCACCCCCGGTCTGGAACACCGCATCGGC
GGGCTGGAAGCTGCCAATGGCTCGGGCGACATCTCCTACGAGCCGACTAATCATGACCTC
ATGGTCCGGTTGCGCCAAGCCAAGATCGACGGTATCCATGTTCCCGATCTGGAAGTCGAT
GATCCGACCGGGGACGCCGAGCTGTTGTTGATCGGGTGGGGCAGCTCCTACGGCCCAATC
GGTGAAGCGTGCCGGCGCGCGCGTCGCCGAGGCACCAAGGTAGCGCACGCCCATCTGCGC
TATCTCAACCCGTTCCCGGCCAATTTGGGTGAGGTGCTGCGGCGTTACCCCAAGGTGGTG
GCTCCGGAGTTGAACTTGGGCCAGCTGGCCCAGGTGCTGCGCGGTAAGTACCTGGTCGAC
GTGCAATCGGTCACCAAGGTTAAGGGTGTCTCGTTCCTGGCCGACGAGATTGGGCGCTTT
ATCCGGGCCGCACTTGCCGGGAGATTGGCCGAGCTTGAGCAAGACAAGACGTTGGTCGCC
AGATTGTCGGCGGCCACGGCGGGAGCGGGAGCAAACGGATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2454c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,AK. Ojha,AD. Baughn,D. Sambandan,T. Hsu,X. Trivelli,Y. Guerardel,A. Alahari,L. Kremer,WR. Jacobs,GF. Hatfull Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv2454c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,HI. Boshoff,CE. Barry Tuberculosis - metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 2005
Interaction	PhysicalInteraction Rv2454c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,AK. Ojha,AD. Baughn,D. Sambandan,T. Hsu,X. Trivelli,Y. Guerardel,A. Alahari,L. Kremer,WR. Jacobs,GF. Hatfull Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv2454c	active	jgalag	2012-10-05
	Spectropfotometric Analysis authors,HI. Boshoff,CE. Barry Tuberculosis - metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 2005
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:1.2.7.3 2-oxoglutarate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype AD. Baughn, SJ. Garforth et al. An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. PLoS Pathog. 2009
Term	EC:1.2.7.3 2-oxoglutarate synthase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011