Rv2496c - pyruvate dehydrogenase E1 component beta subunit pdhB
Protein Domains

Gene Information
LocusRv2496c
SymbolpdhB
Gene Namepyruvate dehydrogenase E1 component beta subunit pdhB
Location2809936 - 2810982 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1047 bp
Protein:349 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number29896
Related GenesMAP2308c MAP2309c MAV_1675 MAV_1676 Mkms_3698 Mkms_3699 Mmcs_3625 Mmcs_3626 MSMEG_4711 MSMEG_4712 MT2571 MT2572 MUL_3774 MUL_3775 Mvan_4085 Mvan_4086 Rv2497c SAV4363
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv2496c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionOperon Rv2497cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2497cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2495cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2495cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionRegulatedBy Rv3286cactiveyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
EP. Williams, JH. Lee et al. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J. Bacteriol. 2007
TermEC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
TermEC:1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
TermEC:1.2.4.1 Pyruvate dehydrogenase (acetyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
TermEC:1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011