Rv2591 - PE-PGRS family protein

Expression: Most Significant Conditions for Rv2591

Protein Domains

Gene Information
Locus	Rv2591
Symbol	PE_PGRS44
Gene Name	PE-PGRS family protein
Location	2921551 - 2923182 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1632 bp Protein:544 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	37132
Related Genes	CE1765 cg1857 DIP1363 jk1047 MUL_1721
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2591
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2591 Transcript 1
MSFVTAAPEMLATAAQNVANIGTSLSAANATAAASTTSVLAAGADEVSQAIARLFSDYAT
HYQSLNAQAAAFHHSFVQTLNAAGGAYSSAEAANASAQALEQNLLAVINAPAQALFGRPL
IGNGANGTAASPNGGDGGILYGNGGNGFSQTTAGVAGGAGGSAGLIGNGGNGGAGGAGAA
GGAGGAGGWLLGNGGAGGPGGPTDVPAGTGGAGGAGGDAPLIGWGGNGGPGGFAAFGNGG
AGGNGGASGSLFGVGGAGGVGGSSEDVGGTGGAGGAGRGLFLGLGGDGGAGGTSNNNGGD
GGAGGTAGGRLFSLGGDGGNGGAGTAIGSNAGDGGAGGDSSALIGYAQGGSGGLGGFGES
TGGDGGLGGAGAVLIGTGVGGFGGLGGGSNGTGGAGGAGGTGATLIGLGAGGGGGIGGFA
VNVGNGVGGLGGQGGQGAALIGLGAGGAGGAGGATVVGLGGNGGDGGDGGGLFSIGVGGD
GGNAGNGAMPANGGNGGNAGVIANGSFAPSFVGFGGNGGNGVNGGTGGSGGILFGANGAN
GPS*

Genomic Sequence

>Rv2591
ATGTCGTTTGTCACGGCAGCTCCAGAGATGCTGGCGACGGCGGCGCAGAATGTCGCGAAT
ATCGGCACATCGCTGAGTGCGGCAAACGCGACGGCAGCGGCGTCCACGACCTCGGTGCTG
GCGGCCGGAGCCGACGAGGTATCGCAGGCTATCGCAAGGCTGTTCAGTGATTACGCCACG
CACTATCAGTCGCTGAACGCTCAAGCCGCGGCATTTCATCACAGCTTCGTGCAAACGTTG
AACGCCGCCGGTGGCGCCTATTCGAGCGCCGAGGCGGCCAACGCTTCGGCGCAGGCGTTG
GAACAGAATCTGTTGGCCGTGATCAATGCGCCCGCCCAGGCGTTGTTCGGGCGTCCCCTG
ATCGGCAATGGCGCGAATGGAACAGCGGCCAGCCCCAACGGCGGTGATGGTGGGATTTTG
TACGGCAACGGCGGCAACGGCTTCTCCCAAACGACCGCCGGGGTGGCCGGCGGCGCCGGT
GGTTCCGCGGGCCTGATCGGCAACGGCGGCAATGGTGGCGCCGGTGGGGCCGGTGCTGCC
GGCGGGGCCGGCGGCGCCGGCGGATGGCTGCTCGGCAACGGTGGCGCCGGCGGTCCCGGC
GGCCCAACGGACGTTCCTGCCGGCACAGGTGGAGCCGGCGGGGCCGGCGGCGACGCCCCA
TTGATCGGCTGGGGCGGCAACGGCGGGCCCGGCGGTTTCGCTGCTTTTGGAAACGGTGGG
GCCGGCGGCAACGGCGGCGCCAGCGGTTCGCTCTTTGGCGTCGGCGGCGCCGGCGGCGTC
GGCGGATCGAGCGAAGACGTCGGCGGCACCGGCGGGGCCGGCGGCGCTGGCCGCGGTCTA
TTCCTTGGCCTGGGCGGTGATGGCGGCGCCGGCGGCACCAGCAACAACAACGGCGGTGAC
GGTGGCGCCGGCGGCACCGCGGGAGGTCGATTGTTCAGCCTGGGCGGTGACGGTGGCAAC
GGTGGTGCCGGTACCGCAATCGGATCCAACGCCGGTGACGGTGGCGCCGGCGGTGACAGC
AGCGCCCTGATCGGCTACGCCCAGGGCGGCTCCGGCGGCCTCGGCGGCTTCGGCGAAAGT
ACCGGCGGCGACGGCGGCCTGGGCGGCGCCGGCGCTGTGCTCATCGGCACGGGCGTCGGC
GGTTTCGGCGGCCTCGGTGGCGGCTCCAACGGCACCGGGGGCGCGGGCGGCGCGGGCGGC
ACGGGCGCCACGCTGATCGGCCTGGGCGCCGGCGGCGGCGGCGGCATCGGCGGGTTCGCC
GTCAACGTGGGCAACGGCGTCGGCGGTCTGGGCGGCCAGGGCGGCCAGGGCGCCGCGCTG
ATCGGCCTGGGCGCCGGCGGTGCCGGCGGTGCCGGCGGCGCCACAGTCGTTGGACTTGGT
GGCAATGGCGGTGACGGCGGTGACGGTGGCGGCCTGTTTAGTATCGGCGTCGGTGGGGAC
GGCGGCAACGCCGGCAACGGCGCCATGCCTGCCAATGGCGGCAACGGCGGCAACGCCGGG
GTCATTGCCAACGGCTCCTTTGCCCCGTCGTTCGTCGGCTTCGGCGGCAACGGCGGCAAC
GGCGTCAATGGCGGCACCGGCGGCAGCGGCGGGATCCTTTTTGGCGCCAACGGCGCGAAC
GGACCGTCGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift M. Stapleton, I. Haq et al. Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties. J. Biol. Chem. 2010
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	active	xaccheus	2012-10-05
	authors,Y. Akhter,S. Yellaboina,A. Farhana,A. Ranjan,N. Ahmed,SE. Hasnain Genome scale portrait of cAMP-receptor protein (CRP) regulons in mycobacteria points to their role in pathogenesis. Gene 2008
Interaction	RegulatedBy Rv2710	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, PC. Karakousis et al. Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network. J. Bacteriol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008