Rv2703 - RNA polymerase sigma factor sigA

Expression: Most Significant Conditions for Rv2703

Protein Domains

Gene Information
Locus	Rv2703
Symbol	sigA
Gene Name	RNA polymerase sigma factor sigA
Location	3017835 - 3019421 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1587 bp Protein:529 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33607
Related Genes	CE1804 CE1811 cg2092 cg2102 DIP1406 DIP1413 jk1087 jk1094 MAP2820 MAP2826 MAV_3595 MAV_3603 Mkms_2223 Mkms_2231 ML1014 ML1022 Mmcs_2177 Mmcs_2185 MSMEG_2752 MSMEG_2758 MT2777 MT2783 MUL_3341 MUL_3350 Mvan_2451 Mvan_2461 nfa37590 nfa37750 Rv2710 SAV3694
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2703
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2703 Transcript 1
MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKP
ASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVE
ELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPG
QTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
LNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANL
RLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMA
DQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREP
ISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFG
LTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD*

Genomic Sequence

>Rv2703
GTGGCAGCGACCAAAGCAAGCACGGCGACCGATGAGCCGGTAAAACGCACCGCCACCAAG
TCGCCCGCGGCTTCCGCGTCCGGGGCCAAGACCGGCGCCAAGCGAACAGCGGCGAAGTCC
GCTAGTGGCTCCCCACCCGCGAAGCGGGCTACCAAGCCCGCGGCCCGGTCCGTCAAGCCC
GCCTCGGCACCCCAGGACACTACGACCAGCACCATCCCGAAAAGGAAGACCCGCGCCGCG
GCCAAATCCGCCGCCGCGAAGGCACCGTCGGCCCGCGGCCACGCGACCAAGCCACGGGCG
CCCAAGGATGCCCAGCACGAAGCCGCAACGGATCCCGAGGACGCCCTGGACTCCGTCGAG
GAGCTCGACGCTGAACCAGACCTCGACGTCGAGCCCGGCGAGGACCTCGACCTTGACGCC
GCCGACCTCAACCTCGATGACCTCGAGGACGACGTGGCGCCGGACGCCGACGACGACCTC
GACTCGGGCGACGACGAAGACCACGAAGACCTCGAAGCTGAGGCGGCCGTCGCGCCCGGC
CAGACCGCCGATGACGACGAGGAGATCGCTGAACCCACCGAAAAGGACAAGGCCTCCGGT
GATTTCGTCTGGGATGAAGACGAGTCGGAGGCCCTGCGTCAAGCACGCAAGGACGCCGAA
CTCACCGCATCCGCCGACTCGGTTCGCGCCTACCTCAAACAGATCGGCAAGGTAGCGCTG
CTCAACGCCGAGGAAGAGGTCGAGCTAGCCAAGCGGATCGAGGCTGGCCTGTACGCCACG
CAGCTGATGACCGAGCTTAGCGAGCGCGGCGAAAAGCTGCCTGCCGCCCAGCGCCGCGAC
ATGATGTGGATCTGCCGCGACGGCGATCGCGCGAAAAACCATCTGCTGGAAGCCAACCTG
CGCCTGGTGGTTTCGCTAGCCAAGCGCTACACCGGCCGGGGCATGGCGTTTCTCGACCTG
ATCCAGGAAGGCAACCTGGGGCTGATCCGCGCGGTGGAGAAGTTCGACTACACCAAGGGG
TACAAGTTCTCCACCTACGCTACGTGGTGGATTCGCCAGGCCATCACCCGCGCCATGGCC
GACCAGGCCCGCACCATCCGCATCCCGGTGCACATGGTCGAGGTGATCAACAAGCTGGGC
CGCATTCAACGCGAGCTGCTGCAGGACCTGGGCCGCGAGCCCACGCCCGAGGAGCTGGCC
AAAGAGATGGACATCACCCCGGAGAAGGTGCTGGAAATCCAGCAATACGCCCGCGAGCCG
ATCTCGTTGGACCAGACCATCGGCGACGAGGGCGACAGCCAGCTTGGCGATTTCATCGAA
GACAGCGAGGCGGTGGTGGCCGTCGACGCGGTGTCCTTCACTTTGCTGCAGGATCAACTG
CAGTCGGTGCTGGACACGCTCTCCGAGCGTGAGGCGGGCGTGGTGCGGCTACGCTTCGGC
CTTACCGACGGCCAGCCGCGCACCCTTGACGAGATCGGCCAGGTCTACGGCGTGACCCGG
GAACGCATCCGCCAGATCGAATCCAAGACTATGTCGAAGTTGCGCCATCCGAGCCGCTCA
CAGGTCCTGCGCGACTACCTGGACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3416	active	chirupolo	2012-10-05
	Affinity purification (Physical interaction) AJ. Steyn, DM. Collins et al. Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proc. Natl. Acad. Sci. U.S.A. 2002
Interaction	Regulatory Rv3416	active	chirupolo	2012-10-05
	Affinity purification (Physical interaction) B. Hutter & T. Dick Molecular genetic characterisation of whiB3, a mycobacterial homologue of a Streptomyces sporulation factor. Res. Microbiol. 1999
Interaction	Regulatory Rv3416	active	chirupolo	2012-10-05
	Yeast two-hybrid (Physical interaction) AJ. Steyn, DM. Collins et al. Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proc. Natl. Acad. Sci. U.S.A. 2002
Interaction	Regulatory Rv3416	active	chirupolo	2012-10-05
	Yeast two-hybrid (Physical interaction) B. Hutter & T. Dick Molecular genetic characterisation of whiB3, a mycobacterial homologue of a Streptomyces sporulation factor. Res. Microbiol. 1999
Interaction	Regulatory Rv3416	active	priyadarshinipriyanka2001	2012-10-05
	Yeast two-hybrid (Physical interaction) AJ. Steyn, DM. Collins et al. Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proc. Natl. Acad. Sci. U.S.A. 2002
Interaction	Regulatory Rv3416	active	priyadarshinipriyanka2001	2012-10-05
	Yeast two-hybrid (Physical interaction) authors,M. Gomez,L. Doukhan,G. Nair,I. Smith sigA is an essential gene in Mycobacterium smegmatis. Mol. Microbiol. 1998
Interaction	Regulatory Rv2416c	active	hibeeluck	2012-10-05
	co expression(functional linkage) MA. Zaunbrecher, RD. Sikes et al. Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2009
Interaction	Regulatory Rv2416c	active	hibeeluck	2012-10-05
	co expression(functional linkage) S. Wu, PF. Barnes et al. Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth. Microbiology (Reading, Engl.) 2009
Interaction	PhysicalInteraction Rv0668	active	prabhakarsmail	2012-10-05
	Kinetic Assays LP. Miller, JT. Crawford et al. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 1994
Interaction	PhysicalInteraction Rv0667	active	prabhakarsmail	2012-10-05
	Kinetic Assays LP. Miller, JT. Crawford et al. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 1994
Interaction	Transcription Rv0185	active	aparna.vchalam	2012-10-05
	Co-expression (Functional linkage) S. Wu, PF. Barnes et al. Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth. Microbiology (Reading, Engl.) 2009
Interaction	Transcription Rv0184	active	aparna.vchalam	2012-10-05
	Co-expression (Functional linkage) S. Wu, PF. Barnes et al. Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth. Microbiology (Reading, Engl.) 2009
Interaction	Transcription Rv0181c	active	aparna.vchalam	2012-10-05
	Co-expression (Functional linkage) S. Wu, PF. Barnes et al. Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth. Microbiology (Reading, Engl.) 2009
Interaction	RegulatedBy Rv3223c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006