Rv2995c - 3-isopropylmalate dehydrogenase leuB

Expression: Most Significant Conditions for Rv2995c

Protein Domains

Gene Information
Locus	Rv2995c
Symbol	leuB
Gene Name	3-isopropylmalate dehydrogenase leuB
Location	3352458 - 3353468 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1011 bp Protein:337 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32583
Related Genes	Acel_0710 BL1218 CE1383 cg1453 DIP1105 jk1288 MAP3032c MAV_3845 Mkms_1957 ML1691 Mmcs_1911 MSMEG_2379 MT3073 MUL_1953 Mvan_2129 nfa42200 SAV2718 SCO5522
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2995c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2995c Transcript 1
MKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNH
DAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVV
REGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTN
VLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDL
AAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGE
HDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL*

Genomic Sequence

>Rv2995c
ATGAAACTCGCGATCATTGCCGGTGACGGGATCGGGCCCGAGGTAACCGCCGAGGCGGTC
AAAGTGCTCGACGCGGTTGTGCCGGGCGTCCAGAAAACCAGCTATGACCTGGGTGCGCGG
CGCTTTCATGCCACCGGCGAGGTGCTGCCGGACTCGGTGGTGGCCGAGCTGCGCAACCAC
GACGCGATCCTGCTCGGGGCGATCGGTGACCCGTCGGTGCCAAGCGGCGTCTTGGAGCGC
GGTCTGTTGCTGCGACTGCGCTTCGAGCTGGATCACCACATCAACCTGCGTCCGGCCCGG
CTGTATCCGGGGGTGGCCAGCCCGCTGTCCGGCAATCCCGGCATCGACTTCGTGGTGGTG
CGCGAGGGCACCGAGGGACCCTACACCGGCAACGGCGGGGCGATTCGCGTCGGCACGCCC
AACGAGGTGGCCACCGAAGTCAGCGTGAACACCGCGTTCGGTGTGCGGCGTGTGGTTGCC
GACGCGTTCGAGCGGGCTCGACGGCGTCGCAAGCATCTGACATTGGTGCACAAAACGAAC
GTGTTGACCTTCGCCGGGGGATTGTGGTTGCGGACCGTCGACGAGGTCGGCGAATGCTAC
CCGGACGTCGAGGTGGCCTACCAGCACGTCGACGCCGCCACCATCCACATGATCACCGAC
CCGGGTCGCTTCGACGTGATCGTCACCGACAACCTGTTCGGCGACATCATCACCGATCTG
GCCGCGGCGGTATGTGGCGGTATCGGCTTGGCGGCCAGTGGGAATATCGACGCGACCCGG
GCCAACCCGTCGATGTTCGAGCCGGTGCATGGCAGCGCGCCGGACATCGCCGGTCAGGGC
ATCGCCGACCCGACGGCGGCGATCATGTCGGTGGCGTTATTGCTGTCCCACCTTGGCGAA
CACGACGCGGCTGCCCGGGTGGACCGGGCCGTCGAGGCCCATTTGGCCACGCGTGGCAGC
GAACGGCTTGCCACCAGCGATGTCGGCGAACGGATTGCCGCCGCGCTCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3291c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:1.1.1.85 3-isopropylmalate dehydrogenase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,M. Pátek,J. Hochmannová,M. Jelínková,J. Nesvera,L. Eggeling Analysis of the leuB gene from Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 1998