Rv3206c - molybdenum cofactor biosynthesis protein moeB1

Expression: Most Significant Conditions for Rv3206c

Protein Domains

Gene Information
Locus	Rv3206c
Symbol	moeB1
Gene Name	molybdenum cofactor biosynthesis protein moeB1
Location	3582532 - 3583710 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1179 bp Protein:393 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	2408
Related Genes	Acel_1777 BL1054 CE0183 CE1937 cg0257 cg2240 DIP0034 DIP0492 jk0849 jk1596 MAP3306c MAV_4153 Mkms_1417 ML0817 Mmcs_1399 MSMEG_1937 MT3198 MT3301 MUL_2527 Mvan_1797 nfa45670 PPA0518 Rv3116 SAV3082
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3206c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3206c Transcript 1
MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARVLVIGAGGLGAPTLLY
LAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDSIVAINPLIRVRLHELR
LAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWGSIYRFEGQASVFWEDAP
DGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVASVMGTEAIKLITGIGETLLGRLL
VYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAAQAAKGSTITPRELRDWLDS
GRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKLPQDRTAVLYCKTGVRSAEAL
AAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY*

Genomic Sequence

>Rv3206c
GTGTCGACATCCTTGCCGCCACTAGTTGAGCCAGCATCCGCGCTCAGCCGTGAAGAGGTA
GCTCGCTACAGCCGCCATCTCATCATTCCTGACCTGGGTGTTGACGGGCAGAAGAGGCTC
AAGAACGCGCGAGTACTGGTGATCGGCGCCGGCGGGCTCGGAGCGCCCACGTTATTGTAT
CTGGCCGCCGCCGGCGTCGGCACCATCGGCATCGTCGACTTCGATGTGGTTGACGAGTCG
AACCTGCAGCGCCAGGTCATCCATGGGGTAGCTGACGTCGGGCGCTCCAAGGCTCAGTCG
GCGCGCGATTCGATTGTCGCGATCAACCCGCTGATCCGGGTGCGACTACACGAGCTGCGG
CTTGCGCCGAGCAACGCCGTCGACCTGTTCAAGCAGTACGACCTGATCTTGGATGGCACC
GACAACTTCGCCACCCGGTATCTGGTCAACGACGCCGCGGTGCTGGCTGGCAAGCCGTAC
GTGTGGGGGTCGATTTACCGCTTCGAGGGCCAGGCATCGGTGTTTTGGGAGGACGCCCCC
GACGGGTTGGGTGTCAACTACCGCGACCTGTATCCCGAGCCGCCGCCGCCGGGCATGGTG
CCGTCCTGTGCTGAAGGCGGGGTGCTGGGCATTATCTGTGCCTCGGTCGCATCGGTGATG
GGCACTGAGGCGATCAAGCTGATCACCGGGATAGGTGAAACACTGCTTGGCCGGTTGCTG
GTGTACGACGCGCTGGAGATGAGCTATCGCACGATCACCATCCGCAAGGACCCATCGACA
CCGAAGATCACCGAGCTGGTCGACTACGAACAGTTCTGCGGCGTGGTTGCTGACGATGCC
GCCCAGGCGGCCAAAGGTTCCACCATCACGCCGCGCGAGCTGCGCGACTGGCTGGACTCC
GGCCGTAAGCTGGCACTGATCGACGTTCGCGATCCCGTGGAGTGGGACATCGTGCATATC
GACGGAGCCCAACTGATTCCGAAATCGTTGATCAACTCGGGTGAGGGTCTGGCCAAGCTC
CCCCAGGACCGCACCGCCGTGCTGTACTGCAAGACGGGCGTGCGCTCGGCCGAGGCATTG
GCTGCGGTCAAGAAAGCCGGTTTCTCCGACGCGGTACACCTGCAGGGTGGGATCGTCGCG
TGGGCCAAGCAGATGCAGCCCGACATGGTGATGTACTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activation Rv0868c	active	girishgene07	2012-10-05
	co-occurrence (functional linkage) authors,CT. Lauhon,R. Kambampati The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD. J. Biol. Chem. 2000
Interaction	Activation Rv0868c	active	girishgene07	2012-10-05
	co-occurrence (functional linkage) authors,K. Mieno [Digestive tract disease in the surgical department and acute abdomen]. Kango Gijutsu 1979
Interaction	Activation Rv0868c	active	girishgene07	2012-10-05
	co-occurrence (functional linkage) authors,W. Zhang,A. Urban,H. Mihara,S. Leimkühler,T. Kurihara,N. Esaki IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli. J. Biol. Chem. 2010
Interaction	RegulatedBy Rv3223c	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Symbol	moeZR	active	mwilliams	2012-03-16
	thiosulfate:sulfurtransferase activity authors,M. Voss,M. Nimtz,S. Leimkühler Elucidation of the dual role of mycobacterial MoeZR in molybdenum cofactor biosynthesis and cysteine biosynthesis. PLoS ONE 2011
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,B. Teusink,FH. van Enckevort,C. Francke,A. Wiersma,A. Wegkamp,EJ. Smid,RJ. Siezen In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments. Appl. Environ. Microbiol. 2005