Rv3266c - dTDP-6-deoxy-L-lyxo-4-hexulose reductase rmlD

Expression: Most Significant Conditions for Rv3266c

Protein Domains

Gene Information
Locus	Rv3266c
Symbol	rmlD
Gene Name	dTDP-6-deoxy-L-lyxo-4-hexulose reductase rmlD
Location	3646895 - 3647809 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:915 bp Protein:305 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33272
Related Genes	jk1647 MAP3380c MAV_4231 Mkms_1336 ML0751 Mmcs_1319 MSMEG_1825 MT3366 MUL_2612 Mvan_1727 nfa46380
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3266c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3266c Transcript 1
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVIN
CAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPY
EPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGR
VDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
RVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLP
STRD*

Genomic Sequence

>Rv3266c
ATGGCGGGCAGGTCAGAAAGGCTAGTCATCACCGGTGCGGGCGGGCAGCTGGGCAGCCAT
CTGACGGCACAGGCCGCCCGGGAAGGCCGCGATATGCTGGCGCTGACTTCCTCGCAGTGG
GATATCACCGACCCCGCTGCGGCCGAGCGGATCATCCGACACGGTGACGTGGTGATCAAT
TGCGCCGCCTACACCGACGTCGACGGCGCCGAGAGCAATGAGGCAGTCGCCTATGCGGTC
AATGCCACTGGCCCGCAACACCTCGCCCGTGCGTGCGCTCGTGTGGGTGCTCGGTTAATC
CACGTCTCCACCGACTACGTATTCGATGGCGACTTCGGCGGCGCCGAGCCCCGGCCCTAC
GAGCCCACCGATGAAACCGCGCCGCAGGGCGTGTATGCCCGCAGCAAACTCGCCGGCGAG
CAGGCTGTGCTGGCAGCGTTCCCGGAGGCTGCCGTGGTACGGACCGCCTGGGTCTACACC
GGCGGGACCGGCAAGGATTTCGTCGCCGTCATGCGCCGGCTGGCCGCCGGACACGGTCGG
GTGGATGTGGTCGACGACCAGACCGGGTCGCCGACCTACGTCGCCGACCTGGCCGAGGCG
CTGCTGGCGTTGGCCGACGCGGGCGTGCGCGGACGCGTGTTGCACGCCGCTAACGAGGGC
GTGGTCTCCCGGTTCGGTCAAGCCCGCGCGGTGTTCGAAGAATGCGGTGCCGACCCACAG
CGGGTGCGTCCGGTCAGCAGCGCGCAGTTTCCGCGGCCCGCGCCGCGTTCGAGCTATTCC
GCGCTGTCGAGCAGGCAGTGGGCGCTGGCGGGCTTGACGCCGCTACGGCACTGGCGCAGC
GCACTGGCCACGGCGCTGGCAGCACCTGCGAACTCAACTTCGATCGATCGACGGTTACCC
TCAACGCGTGACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Name	Formation of dTDP--L-Rhamnose, the fourth and final step in dTDP-Rha synthesis	active	mjackson	2012-10-05
	dTDP-Rhamnose synthesis
Term	GO:0019305 dTDP-rhamnose biosynthetic process - NR	active	mmcneil	2012-03-05
	dTDP-Rha synthase: Formation of dTDP-β-L-Rhamnose, the fourth and final step in dTDP-Rha synthesis; enzymatic evidence Y. Ma, RJ. Stern et al. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob. Agents Chemother. 2001