Rv3464 - dTDP-glucose 4,6-dehydratase rmlB

Expression: Most Significant Conditions for Rv3464

Protein Domains

Gene Information
Locus	Rv3464
Symbol	rmlB
Gene Name	dTDP-glucose 4,6-dehydratase rmlB
Location	3881837 - 3882832 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:996 bp Protein:332 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	35595
Related Genes	Acel_0415 BL0229 CE0344 cg0403 DIP0362 jk1888 MAP4225c MAV_4406 Mkms_1082 ML1964 Mmcs_1066 MSMEG_1512 MT3570 MUL_0840 Mvan_1365 SAV946
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3464
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3464 Transcript 1
MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIRLVQGDITD
AELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRHGVRLHHIST
DEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGP
YQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTYLISS
EGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTDFEEG
LRTTIDWYRDNESWWRPLKDATEARYQERGQ*

Genomic Sequence

>Rv3464
ATGCGGTTGCTAGTCACCGGTGGCGCGGGATTCATCGGCACGAATTTCGTGCACAGCGCC
GTACGTGAGCATCCAGACGATGCGGTTACCGTACTCGACGCCCTGACCTACGCCGGCCGG
CGCGAGTCGCTGGCCGACGTGGAGGATGCCATCCGGCTGGTTCAGGGCGATATCACCGAC
GCCGAGCTGGTTTCGCAGCTGGTGGCCGAGTCCGACGCGGTGGTGCATTTTGCCGCCGAA
TCCCATGTCGACAATGCACTGGACAATCCGGAGCCGTTTCTGCACACCAACGTCATCGGG
ACCTTCACCATCCTGGAAGCGGTGCGACGCCACGGTGTGCGCCTGCACCACATCTCCACC
GACGAGGTCTACGGCGACTTGGAGCTCGACGACCGGGCGCGGTTCACCGAATCGACGCCC
TATAACCCGTCCAGCCCTTACTCGGCGACCAAGGCGGGCGCAGACATGTTGGTCCGGGCC
TGGGTTCGGTCCTATGGCGTACGCGCGACGATCTCCAACTGCTCCAACAACTACGGGCCG
TATCAGCACGTCGAGAAGTTCATTCCGCGTCAGATCACCAATGTGCTCACCGGGCGGCGG
CCCAAGCTCTACGGCGCGGGCGCCAATGTCCGTGACTGGATCCACGTCGACGACCACAAC
AGCGCGGTGCGGCGAATCCTGGACAGAGGCCGCATCGGCCGAACCTACCTGATCAGCTCC
GAGGGCGAGCGTGACAACCTGACCGTGCTGCGCACGCTGCTGCGACTGATGGACCGCGAT
CCGGACGACTTCGACCACGTCACCGACCGCGTCGGCCACGACCTGCGCTATGCCATCGAC
CCGTCCACGCTCTACGACGAATTATGCTGGGCGCCAAAGCATACCGATTTCGAGGAGGGC
CTGCGGACCACGATCGACTGGTACCGCGACAACGAATCGTGGTGGCGTCCACTAAAAGAC
GCCACGGAGGCCCGCTATCAAGAACGCGGTCAATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	dTDP-Glucose dehydratase: Formation of dTDP--D-xylo-4-keto-6-deoxy-hexulose, the second step in dTDP-Rha synthesis	active	mjackson	2012-10-05
	dTDP-Rhamnose synthesis
Term	GO:0019305 dTDP-rhamnose biosynthetic process - NR	active	mmcneil	2012-03-05
	dTDP-Rha pathway: dTDP-Glucose dehydratase: Formation of dTDP-α-D-xylo-4-keto-6-deoxy-hexulose, the second step in dTDP-Rha synthesis; enzymatic evidence Y. Ma, RJ. Stern et al. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob. Agents Chemother. 2001